Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral

• Published in: Science Advances
• Main Authors: Liew, Yi Jin, Zoccola, Didier, Li, Yong, Tambutté, Eric, Venn, Alexander A., Michell, Craig, Cui, Guoxin, Deutekom, Eva S., Kaandorp, Jaap A., Voolstra, Christian R., Forêt, Sylvain, Allemand, Denis, Tambutté, Sylvie, Aranda, Manuel
• Other Authors: Red Sea Research Center (RSRC), Biological and Environmental Sciences and Engineering (BESE) Division, Bioscience Program, Marine Science Program, Centre Scientifique de Monaco, Department of Marine Biology, , Monaco, Department of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, , Finland, Computational Science Lab, Faculty of Science, University of Amsterdam, Amsterdam, , Netherlands, Research School of Biology, Australian National University, Canberra, ACT, , Australia
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: American Association for the Advancement of Science (AAAS) 2018
• Subjects: Epigenetics; DNA methylation; coral reef; cnidarian; ocean acidification; Ocean acidification
• Online Access: http://hdl.handle.net/10754/625479; https://doi.org/10.1126/sciadv.aar8028; https://doi.org/10.1101/188227

There are increasing concerns that the current rate of climate change might outpace the ability of reef-building corals to adapt to future conditions. Work on model systems has shown that environmentally induced alterations in DNA methylation can lead to phenotypic acclimatization. While DNA methylation has been reported in corals and is thought to associate with phenotypic plasticity, potential mechanisms linked to changes in whole-genome methylation have yet to be elucidated. We show that DNA methylation significantly reduces spurious transcription in the coral Stylophora pistillata. Furthermore, we find that DNA methylation also reduces transcriptional noise by fine-tuning the expression of highly expressed genes. Analysis of DNA methylation patterns of corals subjected to long-term pH stress showed widespread changes in pathways regulating cell cycle and body size. Correspondingly, we found significant increases in cell and polyp sizes that resulted in more porous skeletons, supporting the hypothesis that linear extension rates are maintained under conditions of reduced calcification. These findings suggest an epigenetic component in phenotypic acclimatization that provides corals with an additional mechanism to cope with environmental change. We thank D. Desgre, N. Caminiti-Segonds, and N. Techer for assistance in coral husbandry; the King Abdullah University of Science and Technology (KAUST) Sequencing Core Facility for the sequencing of the libraries; N. Techer for cell size measurements; P. Alemanno and C. Sattonnet (Polyclinique Saint Jean, Cagnes-sur-Mer, France) for access to the micro-CT; and M. V. Matz and two anonymous reviewers for valuable feedback on our preprint and manuscript. This publication is based on work supported by the KAUST Office of Sponsored Research under award no. FCC/1/1973-22-01. Part of this study was conducted as part of the Centre Scientifique de Monaco Research Program, which is supported by the Government of the Principality of Monaco.