Screening for abdominal aortic aneurysm
Abdominal Aortic Aneurysm (AAA) is a common disease with a prevalence of 1.5-2.0% in 65-year old men in Sweden. The risk of having AAA is increased with smoking, high age, family history of AAA and cardiovascular disease. Women have a lower prevalence (0.5%) and develop AAA later in life. An AAA sel...
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Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset
2014
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ftkarolinskainst:oai:openarchive.ki.se:10616/42165 2023-05-15T17:40:19+02:00 Screening for abdominal aortic aneurysm Linné, Anneli 2014-09-19 application/pdf http://hdl.handle.net/10616/42165 eng eng Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset I. High prevalence of abdominal aortic aneurysms in brothers and sisters of patients despite a low prevalence in the population. Anneli Linné, David Lindström, Rebecka Hultgren. J Vasc Surg. 2012 Aug;56(2):305-10. ::doi::10.1016/j.jvs.2012.01.061 ::pmid::22425245 ::isi::000307160400004 II. Screening of Siblings to patients with Abdominal Aortic Aneurysms in Sweden. Anneli Linné, Johan Forsberg, Karin Leander, Ester Ideskog, David Lindström, Rebecka Hultgren. [Submitted] III. Reasons for non-participation in population-based abdominal aortic aneurysm screening. Anneli Linné, Karin Leander, David Lindström, Sven Törnberg, Rebecka Hultgren. Br J Surg. 2014 Apr;101(5):481-7. ::doi::10.1002/bjs.9434 ::pmid::24615380 ::isi::000332700100007 IV. Low postoperative mortality after surgery on patients with screening detected abdominal aortic aneurysms: A Swedvasc registry study. Anneli Linné, Kristian Smidfelt, Marcus Langenskiöld, Rebecka Hultgren, Joakim Nordanstig, Björn Kragsterman, David Lindström. [Accepted] ::pmid::25301773 ::isi::000347739500010 978-91-7549-673-3 http://hdl.handle.net/10616/42165 info:eu-repo/semantics/openAccess info:eu-repo/semantics/doctoralThesis dok 2014 ftkarolinskainst 2022-09-28T22:33:49Z Abdominal Aortic Aneurysm (AAA) is a common disease with a prevalence of 1.5-2.0% in 65-year old men in Sweden. The risk of having AAA is increased with smoking, high age, family history of AAA and cardiovascular disease. Women have a lower prevalence (0.5%) and develop AAA later in life. An AAA seldom gives any symptom prior to rupture. Untreated rupture is associated with 100% mortality, while surgically treated rupture is associated with 25-70% mortality. Prophylactic surgery is associated with a relatively low risk (30-day mortality of 1-3%). Commonly, prophylactic surgery is offered at size 5.5 cm in men and 5.0 cm in women. As a result of randomized trials showing a benefit in terms of AAA-related mortality and all cause mortality, screening of 65-year old men have been implemented in Sweden. If a high proportion of invited persons chose not to participate in as creening programs, this will affect the positive effects of a screening program. Efforts to better understand and thereby to improve the participation rate should be made. This thesis is focused on different aspects of screening for AAA. In the first and second studies we investigated siblings to AAA-patients in two different regions in Sweden. We examined 150 siblings in mid-Sweden (Stockholm) and 379 siblings in north Sweden (Norrbotten). In both regions a prevalence of 17% in brothers and 6% in sisters was found, strikingly high numbers as compared to the general population. We did not detect regional differences in prevalence. Further analysis of the 53 siblings found with AAA revealed that 32% had a large AAA and 16% had a large AAA before the age 65. Organized screening of both male and female siblings is motivated since the population-based screening is not sufficient for all of them. The third study investigated reasons for non-participation in the population based AAA-screening program in Stockholm County. The individual socioeconomic- and health-status of 24319 men invited to screening was investigated and compared between participants ... Doctoral or Postdoctoral Thesis North Sweden Norrbotten Karolinska Institutet: Publications |
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Karolinska Institutet: Publications |
op_collection_id |
ftkarolinskainst |
language |
English |
description |
Abdominal Aortic Aneurysm (AAA) is a common disease with a prevalence of 1.5-2.0% in 65-year old men in Sweden. The risk of having AAA is increased with smoking, high age, family history of AAA and cardiovascular disease. Women have a lower prevalence (0.5%) and develop AAA later in life. An AAA seldom gives any symptom prior to rupture. Untreated rupture is associated with 100% mortality, while surgically treated rupture is associated with 25-70% mortality. Prophylactic surgery is associated with a relatively low risk (30-day mortality of 1-3%). Commonly, prophylactic surgery is offered at size 5.5 cm in men and 5.0 cm in women. As a result of randomized trials showing a benefit in terms of AAA-related mortality and all cause mortality, screening of 65-year old men have been implemented in Sweden. If a high proportion of invited persons chose not to participate in as creening programs, this will affect the positive effects of a screening program. Efforts to better understand and thereby to improve the participation rate should be made. This thesis is focused on different aspects of screening for AAA. In the first and second studies we investigated siblings to AAA-patients in two different regions in Sweden. We examined 150 siblings in mid-Sweden (Stockholm) and 379 siblings in north Sweden (Norrbotten). In both regions a prevalence of 17% in brothers and 6% in sisters was found, strikingly high numbers as compared to the general population. We did not detect regional differences in prevalence. Further analysis of the 53 siblings found with AAA revealed that 32% had a large AAA and 16% had a large AAA before the age 65. Organized screening of both male and female siblings is motivated since the population-based screening is not sufficient for all of them. The third study investigated reasons for non-participation in the population based AAA-screening program in Stockholm County. The individual socioeconomic- and health-status of 24319 men invited to screening was investigated and compared between participants ... |
format |
Doctoral or Postdoctoral Thesis |
author |
Linné, Anneli |
spellingShingle |
Linné, Anneli Screening for abdominal aortic aneurysm |
author_facet |
Linné, Anneli |
author_sort |
Linné, Anneli |
title |
Screening for abdominal aortic aneurysm |
title_short |
Screening for abdominal aortic aneurysm |
title_full |
Screening for abdominal aortic aneurysm |
title_fullStr |
Screening for abdominal aortic aneurysm |
title_full_unstemmed |
Screening for abdominal aortic aneurysm |
title_sort |
screening for abdominal aortic aneurysm |
publisher |
Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset |
publishDate |
2014 |
url |
http://hdl.handle.net/10616/42165 |
genre |
North Sweden Norrbotten |
genre_facet |
North Sweden Norrbotten |
op_relation |
I. High prevalence of abdominal aortic aneurysms in brothers and sisters of patients despite a low prevalence in the population. Anneli Linné, David Lindström, Rebecka Hultgren. J Vasc Surg. 2012 Aug;56(2):305-10. ::doi::10.1016/j.jvs.2012.01.061 ::pmid::22425245 ::isi::000307160400004 II. Screening of Siblings to patients with Abdominal Aortic Aneurysms in Sweden. Anneli Linné, Johan Forsberg, Karin Leander, Ester Ideskog, David Lindström, Rebecka Hultgren. [Submitted] III. Reasons for non-participation in population-based abdominal aortic aneurysm screening. Anneli Linné, Karin Leander, David Lindström, Sven Törnberg, Rebecka Hultgren. Br J Surg. 2014 Apr;101(5):481-7. ::doi::10.1002/bjs.9434 ::pmid::24615380 ::isi::000332700100007 IV. Low postoperative mortality after surgery on patients with screening detected abdominal aortic aneurysms: A Swedvasc registry study. Anneli Linné, Kristian Smidfelt, Marcus Langenskiöld, Rebecka Hultgren, Joakim Nordanstig, Björn Kragsterman, David Lindström. [Accepted] ::pmid::25301773 ::isi::000347739500010 978-91-7549-673-3 http://hdl.handle.net/10616/42165 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1766141205958098944 |