Current understanding and management of nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a kind of rare head and neck cancer in Japan. However, NPC has some unique features. It is one of the most popular cancers in southern China, Southeast Asia, the Arctic, and the middle East/north Africa. This distinctive racial, ethnical, and geographic predispositi...
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ftkanazawauninii:oai:kanazawa-u.repo.nii.ac.jp:00013690 2023-09-05T13:17:38+02:00 Current understanding and management of nasopharyngeal carcinoma Yoshizaki Tomokazu Ito Makoto Murono Shigeyuki Wakisaka Naohiro Kondo Satoru Endo Kazuhira 2012-04-01 http://hdl.handle.net/2297/30325 https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=13690 https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=13690&item_no=1&attribute_id=26&file_no=1 en eng Elsevier 10.1016/j.anl.2011.02.012 http://www.elsevier.com/locate/issn/03858146 https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=13690 http://hdl.handle.net/2297/30325 Auris Nasus Larynx, 39(2), 137-144(2012-04-01) 0385-8146 AA00061157 https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=13690&item_no=1&attribute_id=26&file_no=1 Chemotherapy Epstein-Barr virus LMP1 Molecular targeting therapy Nasopharyngeal carcinoma Radiotherapy Journal Article 2012 ftkanazawauninii 2023-08-17T05:57:31Z Nasopharyngeal carcinoma (NPC) is a kind of rare head and neck cancer in Japan. However, NPC has some unique features. It is one of the most popular cancers in southern China, Southeast Asia, the Arctic, and the middle East/north Africa. This distinctive racial, ethnical, and geographic predisposition to NPC implies that both genetic susceptibility and environmental factors contribute to the development of this tumor. NPC is an Epstein-Barr virus - associated tumor. Consistent elevation of EBV antibody titers is a well-established risk factor of development of NPC. Not only pathophysiological relationship, but also molecular mechanism of EBV-mediated carcinogenesis has been enthusiastically investigated. LMP1, an EBV primary oncogene, upregulates each step of metastasis, and contribute to highly metastatic feature of NPC. A tumor suppressor gene p53 is mostly intact and overexpressed in NPC whereas expression of p16, a cyclin-dependent kinase inhibitory protein, is downregulated in 2/3 of NPC. Intention modulated radiotherapy (IMRT) is now getting prevalent for the treatment of NPC because of complicated structure and location of nasopharynx. A good therapeutic result can be achieved by distributing a high dose to the tumor while keeping down normal tissue complications by reducing radiation dose to normal tissues. Chemotherapy is important to control distant metastasis of chemoradiosensitive NPC, and thus, should play an important role. However, most effective combination of anti-tumor drugs, protocol of chemoradiotherapy has not well-established. Finally, molecular targeting therapy, including targeting EBV gene product, has been developing and on the way to the clinical use. © 2011 Elsevier Ireland Ltd. Article in Journal/Newspaper Arctic Kanazawa University Repository for Academic Resources (KURA) Arctic |
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Kanazawa University Repository for Academic Resources (KURA) |
op_collection_id |
ftkanazawauninii |
language |
English |
topic |
Chemotherapy Epstein-Barr virus LMP1 Molecular targeting therapy Nasopharyngeal carcinoma Radiotherapy |
spellingShingle |
Chemotherapy Epstein-Barr virus LMP1 Molecular targeting therapy Nasopharyngeal carcinoma Radiotherapy Yoshizaki Tomokazu Ito Makoto Murono Shigeyuki Wakisaka Naohiro Kondo Satoru Endo Kazuhira Current understanding and management of nasopharyngeal carcinoma |
topic_facet |
Chemotherapy Epstein-Barr virus LMP1 Molecular targeting therapy Nasopharyngeal carcinoma Radiotherapy |
description |
Nasopharyngeal carcinoma (NPC) is a kind of rare head and neck cancer in Japan. However, NPC has some unique features. It is one of the most popular cancers in southern China, Southeast Asia, the Arctic, and the middle East/north Africa. This distinctive racial, ethnical, and geographic predisposition to NPC implies that both genetic susceptibility and environmental factors contribute to the development of this tumor. NPC is an Epstein-Barr virus - associated tumor. Consistent elevation of EBV antibody titers is a well-established risk factor of development of NPC. Not only pathophysiological relationship, but also molecular mechanism of EBV-mediated carcinogenesis has been enthusiastically investigated. LMP1, an EBV primary oncogene, upregulates each step of metastasis, and contribute to highly metastatic feature of NPC. A tumor suppressor gene p53 is mostly intact and overexpressed in NPC whereas expression of p16, a cyclin-dependent kinase inhibitory protein, is downregulated in 2/3 of NPC. Intention modulated radiotherapy (IMRT) is now getting prevalent for the treatment of NPC because of complicated structure and location of nasopharynx. A good therapeutic result can be achieved by distributing a high dose to the tumor while keeping down normal tissue complications by reducing radiation dose to normal tissues. Chemotherapy is important to control distant metastasis of chemoradiosensitive NPC, and thus, should play an important role. However, most effective combination of anti-tumor drugs, protocol of chemoradiotherapy has not well-established. Finally, molecular targeting therapy, including targeting EBV gene product, has been developing and on the way to the clinical use. © 2011 Elsevier Ireland Ltd. |
format |
Article in Journal/Newspaper |
author |
Yoshizaki Tomokazu Ito Makoto Murono Shigeyuki Wakisaka Naohiro Kondo Satoru Endo Kazuhira |
author_facet |
Yoshizaki Tomokazu Ito Makoto Murono Shigeyuki Wakisaka Naohiro Kondo Satoru Endo Kazuhira |
author_sort |
Yoshizaki Tomokazu |
title |
Current understanding and management of nasopharyngeal carcinoma |
title_short |
Current understanding and management of nasopharyngeal carcinoma |
title_full |
Current understanding and management of nasopharyngeal carcinoma |
title_fullStr |
Current understanding and management of nasopharyngeal carcinoma |
title_full_unstemmed |
Current understanding and management of nasopharyngeal carcinoma |
title_sort |
current understanding and management of nasopharyngeal carcinoma |
publisher |
Elsevier |
publishDate |
2012 |
url |
http://hdl.handle.net/2297/30325 https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=13690 https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=13690&item_no=1&attribute_id=26&file_no=1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
10.1016/j.anl.2011.02.012 http://www.elsevier.com/locate/issn/03858146 https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=13690 http://hdl.handle.net/2297/30325 Auris Nasus Larynx, 39(2), 137-144(2012-04-01) 0385-8146 AA00061157 https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=13690&item_no=1&attribute_id=26&file_no=1 |
_version_ |
1776198732441714688 |