Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases
Shared genetic factors may contribute to the associations between higher levels of physical activity (PA) and lower risk for cardiometabolic diseases (CMDs), and may partially explain these associations observed in cohort studies. To explore this, we used novel methodology to calculate PA genotypes...
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ftjyvaeskylaenun:oai:jyx.jyu.fi:123456789/89130 2024-05-19T07:45:57+00:00 Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases Sillanpää, Elina Tynkkynen, Niko Törmäkangas, Timo Palviainen, Teemu Hyvärinen, Matti Joensuu, Laura Klevjer, Marie Bye, Anja Pesonen, Paula Waller, Katja Kangas, Maarit Männikkö, Minna Vähä-Ypyä, Henri Sievänen, Harri Korpelainen, Raija Jämsä, Timo Niemelä, Maisa Ripatti, Samuli Kujala, Urho Kaprio, Jaakko 2023 application/pdf i74 fulltext http://urn.fi/URN:NBN:fi:jyu-202309155151 eng eng Oxford University Press (OUP) European Journal of Public Health 1101-1262 Supplement_1 33 Conference of HEPA Europe 10.1093/eurpub/ckad133.184 Sillanpää, E., Tynkkynen, N., Törmäkangas, T., Palviainen, T., Hyvärinen, M., Joensuu, L., Klevjer, M., Bye, A., Pesonen, P., Waller, K., Kangas, M., Männikkö, M., Vähä-Ypyä, H., Sievänen, H., Korpelainen, R., Jämsä, T., Niemelä, M., Ripatti, S., Kujala, U., & Kaprio, J. (2023). Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases. European Journal of Public Health , 33 (Supplement_1), i74. https://doi.org/10.1093/eurpub/ckad133.184 CONVID_184875670 URN:NBN:fi:jyu-202309155151 http://urn.fi/URN:NBN:fi:jyu-202309155151 CC BY 4.0 © The Author(s) 2023. Published by Oxford University Press on behalf of the European Public Health Association. openAccess https://creativecommons.org/licenses/by/4.0/ liikunta fyysinen aktiivisuus diabetes sydän- ja verisuonitaudit perinnöllisyystiede conferenceObject http://purl.org/coar/resource_type/c_c94f publishedVersion O1 2023 ftjyvaeskylaenun 2024-04-23T23:38:28Z Shared genetic factors may contribute to the associations between higher levels of physical activity (PA) and lower risk for cardiometabolic diseases (CMDs), and may partially explain these associations observed in cohort studies. To explore this, we used novel methodology to calculate PA genotypes (polygenic risk score, PRS) and validated them against measured or reported PA in three independent cohorts. We then investigated the associations between polygenic inheritance of PA and cardiometabolic risk factors and diseases in two large population-based biobank datasets, and examined whether selected associations were independent of self-reported PA. Our study utilized the UK Biobank as a base dataset (N = 400,124) and constructed genomewide PRSs for both self-reported and device-measured PA using single nucleotide polymorphism (SNP)-specific weights and SBayesR methodology. Both PRSs for PA included over one million SNPs. PRSs were constructed in the Finnish Twin cohort (N = 759–11,528), the Northern Finland Birth Cohort 1966 (N = 3,263–4,061), the Trøndelag Health Study cohort (HUNT, N = 47,148), and the FinnGen (N = 218,792). Cardiometabolic risk factors were measured in laboratory conditions, and CMD outcomes were derived from national health registers (ICD codes). We utilized linear, logistic, and cox regression methods for analysis. Our results showed that genotypes predisposing to higher PA were associated with higher levels of PA in independent datasets, but PRSs accounted for only a limited amount of variation (0.13-1.44%). Genotypes supporting higher PA were associated with lower body mass index [B=-0.002 in HUNT and B=-0.025 in FinnGen] and favorable cardiometabolic health in HUNT (waist circumference [B=-0.003] and HDL cholesterol [B = 0.004]). Genotypes supporting higher PA volumes were associated with lower incidence of CMDs in both HUNT and FinnGen. The strongest associations were found in hypertensive diseases and Type 2 Diabetes. In HUNT, the observed associations were not materially changed ... Conference Object Northern Finland JYX - Jyväskylä University Digital Archive |
institution |
Open Polar |
collection |
JYX - Jyväskylä University Digital Archive |
op_collection_id |
ftjyvaeskylaenun |
language |
English |
topic |
liikunta fyysinen aktiivisuus diabetes sydän- ja verisuonitaudit perinnöllisyystiede |
spellingShingle |
liikunta fyysinen aktiivisuus diabetes sydän- ja verisuonitaudit perinnöllisyystiede Sillanpää, Elina Tynkkynen, Niko Törmäkangas, Timo Palviainen, Teemu Hyvärinen, Matti Joensuu, Laura Klevjer, Marie Bye, Anja Pesonen, Paula Waller, Katja Kangas, Maarit Männikkö, Minna Vähä-Ypyä, Henri Sievänen, Harri Korpelainen, Raija Jämsä, Timo Niemelä, Maisa Ripatti, Samuli Kujala, Urho Kaprio, Jaakko Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases |
topic_facet |
liikunta fyysinen aktiivisuus diabetes sydän- ja verisuonitaudit perinnöllisyystiede |
description |
Shared genetic factors may contribute to the associations between higher levels of physical activity (PA) and lower risk for cardiometabolic diseases (CMDs), and may partially explain these associations observed in cohort studies. To explore this, we used novel methodology to calculate PA genotypes (polygenic risk score, PRS) and validated them against measured or reported PA in three independent cohorts. We then investigated the associations between polygenic inheritance of PA and cardiometabolic risk factors and diseases in two large population-based biobank datasets, and examined whether selected associations were independent of self-reported PA. Our study utilized the UK Biobank as a base dataset (N = 400,124) and constructed genomewide PRSs for both self-reported and device-measured PA using single nucleotide polymorphism (SNP)-specific weights and SBayesR methodology. Both PRSs for PA included over one million SNPs. PRSs were constructed in the Finnish Twin cohort (N = 759–11,528), the Northern Finland Birth Cohort 1966 (N = 3,263–4,061), the Trøndelag Health Study cohort (HUNT, N = 47,148), and the FinnGen (N = 218,792). Cardiometabolic risk factors were measured in laboratory conditions, and CMD outcomes were derived from national health registers (ICD codes). We utilized linear, logistic, and cox regression methods for analysis. Our results showed that genotypes predisposing to higher PA were associated with higher levels of PA in independent datasets, but PRSs accounted for only a limited amount of variation (0.13-1.44%). Genotypes supporting higher PA were associated with lower body mass index [B=-0.002 in HUNT and B=-0.025 in FinnGen] and favorable cardiometabolic health in HUNT (waist circumference [B=-0.003] and HDL cholesterol [B = 0.004]). Genotypes supporting higher PA volumes were associated with lower incidence of CMDs in both HUNT and FinnGen. The strongest associations were found in hypertensive diseases and Type 2 Diabetes. In HUNT, the observed associations were not materially changed ... |
format |
Conference Object |
author |
Sillanpää, Elina Tynkkynen, Niko Törmäkangas, Timo Palviainen, Teemu Hyvärinen, Matti Joensuu, Laura Klevjer, Marie Bye, Anja Pesonen, Paula Waller, Katja Kangas, Maarit Männikkö, Minna Vähä-Ypyä, Henri Sievänen, Harri Korpelainen, Raija Jämsä, Timo Niemelä, Maisa Ripatti, Samuli Kujala, Urho Kaprio, Jaakko |
author_facet |
Sillanpää, Elina Tynkkynen, Niko Törmäkangas, Timo Palviainen, Teemu Hyvärinen, Matti Joensuu, Laura Klevjer, Marie Bye, Anja Pesonen, Paula Waller, Katja Kangas, Maarit Männikkö, Minna Vähä-Ypyä, Henri Sievänen, Harri Korpelainen, Raija Jämsä, Timo Niemelä, Maisa Ripatti, Samuli Kujala, Urho Kaprio, Jaakko |
author_sort |
Sillanpää, Elina |
title |
Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases |
title_short |
Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases |
title_full |
Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases |
title_fullStr |
Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases |
title_full_unstemmed |
Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases |
title_sort |
shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases |
publisher |
Oxford University Press (OUP) |
publishDate |
2023 |
url |
http://urn.fi/URN:NBN:fi:jyu-202309155151 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
European Journal of Public Health 1101-1262 Supplement_1 33 Conference of HEPA Europe 10.1093/eurpub/ckad133.184 Sillanpää, E., Tynkkynen, N., Törmäkangas, T., Palviainen, T., Hyvärinen, M., Joensuu, L., Klevjer, M., Bye, A., Pesonen, P., Waller, K., Kangas, M., Männikkö, M., Vähä-Ypyä, H., Sievänen, H., Korpelainen, R., Jämsä, T., Niemelä, M., Ripatti, S., Kujala, U., & Kaprio, J. (2023). Shared genetic factors may partly explain the associations between physical activity and cardiometabolic diseases. European Journal of Public Health , 33 (Supplement_1), i74. https://doi.org/10.1093/eurpub/ckad133.184 CONVID_184875670 URN:NBN:fi:jyu-202309155151 http://urn.fi/URN:NBN:fi:jyu-202309155151 |
op_rights |
CC BY 4.0 © The Author(s) 2023. Published by Oxford University Press on behalf of the European Public Health Association. openAccess https://creativecommons.org/licenses/by/4.0/ |
_version_ |
1799486073539133440 |