Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe
Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as disease...
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2021
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ftjyvaeskylaenun:oai:jyx.jyu.fi:123456789/77397 2024-05-19T07:40:09+00:00 Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. 2021 application/pdf fulltext http://urn.fi/URN:NBN:fi:jyu-202108184560 eng eng Nature Publishing Group Scientific Reports 2045-2322 11 324605 329332 329326 10.1038/s41598-021-95000-y Research Council of Finland Suomen Akatemia Aminikhah, M., Forsman, J. T., Koskela, E., Mappes, T., Sane, J., Ollgren, J., Kivelä, S. M., & Kallio, E. R. (2021). Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe. Scientific Reports , 11 , Article 16128. https://doi.org/10.1038/s41598-021-95000-y CONVID_99265314 URN:NBN:fi:jyu-202108184560 http://urn.fi/URN:NBN:fi:jyu-202108184560 CC BY 4.0 © 2021 the Authors openAccess https://creativecommons.org/licenses/by/4.0/ Borrelia-bakteerit zoonoosit jyrsijät borrelioosi populaatiodynamiikka Puumala-virus isäntäeläimet infektiot taudinaiheuttajat article http://purl.org/eprint/type/JournalArticle http://purl.org/coar/resource_type/c_2df8fbb1 publishedVersion A1 2021 ftjyvaeskylaenun 2024-04-23T23:38:28Z Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. However, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato bacteria, have gained limited attention in Northern Europe, despite the multiannual abundance fluctuations, the so-called vole cycles, that characterise rodent population dynamics in the region. Here, we quantify the associations between rodent abundance and LB human cases and Puumala Orthohantavirus (PUUV) infections by using two time series (25-year and 9-year) in Finland. Both bank vole (Myodes glareolus) abundance as well as LB and PUUV infection incidence in humans showed approximately 3-year cycles. Without vector transmitted PUUV infections followed the bank vole host abundance fluctuations with two-month time lag, whereas tick-transmitted LB was associated with bank vole abundance ca. 12 and 24 months earlier. However, the strength of association between LB incidence and bank vole abundance ca. 12 months before varied over the study years. This study highlights that the human risk to acquire rodent-borne pathogens, as well as rodent-associated tick-borne pathogens is associated with the vole cycles in Northern Fennoscandia, yet with complex time lags. peerReviewed Article in Journal/Newspaper Fennoscandia JYX - Jyväskylä University Digital Archive |
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JYX - Jyväskylä University Digital Archive |
op_collection_id |
ftjyvaeskylaenun |
language |
English |
topic |
Borrelia-bakteerit zoonoosit jyrsijät borrelioosi populaatiodynamiikka Puumala-virus isäntäeläimet infektiot taudinaiheuttajat |
spellingShingle |
Borrelia-bakteerit zoonoosit jyrsijät borrelioosi populaatiodynamiikka Puumala-virus isäntäeläimet infektiot taudinaiheuttajat Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
topic_facet |
Borrelia-bakteerit zoonoosit jyrsijät borrelioosi populaatiodynamiikka Puumala-virus isäntäeläimet infektiot taudinaiheuttajat |
description |
Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. However, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato bacteria, have gained limited attention in Northern Europe, despite the multiannual abundance fluctuations, the so-called vole cycles, that characterise rodent population dynamics in the region. Here, we quantify the associations between rodent abundance and LB human cases and Puumala Orthohantavirus (PUUV) infections by using two time series (25-year and 9-year) in Finland. Both bank vole (Myodes glareolus) abundance as well as LB and PUUV infection incidence in humans showed approximately 3-year cycles. Without vector transmitted PUUV infections followed the bank vole host abundance fluctuations with two-month time lag, whereas tick-transmitted LB was associated with bank vole abundance ca. 12 and 24 months earlier. However, the strength of association between LB incidence and bank vole abundance ca. 12 months before varied over the study years. This study highlights that the human risk to acquire rodent-borne pathogens, as well as rodent-associated tick-borne pathogens is associated with the vole cycles in Northern Fennoscandia, yet with complex time lags. peerReviewed |
format |
Article in Journal/Newspaper |
author |
Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. |
author_facet |
Aminikhah, Mahdi Forsman, Jukka T. Koskela, Esa Mappes, Tapio Sane, Jussi Ollgren, Jukka Kivelä, Sami M. Kallio, Eva R. |
author_sort |
Aminikhah, Mahdi |
title |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_short |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_full |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_fullStr |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_full_unstemmed |
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe |
title_sort |
rodent host population dynamics drive zoonotic lyme borreliosis and orthohantavirus infections in humans in northern europe |
publisher |
Nature Publishing Group |
publishDate |
2021 |
url |
http://urn.fi/URN:NBN:fi:jyu-202108184560 |
genre |
Fennoscandia |
genre_facet |
Fennoscandia |
op_relation |
Scientific Reports 2045-2322 11 324605 329332 329326 10.1038/s41598-021-95000-y Research Council of Finland Suomen Akatemia Aminikhah, M., Forsman, J. T., Koskela, E., Mappes, T., Sane, J., Ollgren, J., Kivelä, S. M., & Kallio, E. R. (2021). Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe. Scientific Reports , 11 , Article 16128. https://doi.org/10.1038/s41598-021-95000-y CONVID_99265314 URN:NBN:fi:jyu-202108184560 http://urn.fi/URN:NBN:fi:jyu-202108184560 |
op_rights |
CC BY 4.0 © 2021 the Authors openAccess https://creativecommons.org/licenses/by/4.0/ |
_version_ |
1799479716684496896 |