Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota
IgA is the most abundant Ab in the human body. However, most patients with selective IgA deficiency (SIgAD) are asymptomatic. IgM, and to lesser extent IgG Abs, are generally presumed to compensate for the lack of IgA in SIgAD by multiplying and adopting functions of IgA. We used data from the North...
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The American Association of Immunologists
2021
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ftjyvaeskylaenun:oai:jyx.jyu.fi:123456789/75398 2024-05-19T07:45:54+00:00 Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota Mella, Miia A. Lavrinienko, Anton Akhi, Ramin Hindström, Rasmus Nissinen, Antti E. Wang, Chunguang Kullaa, Arja Salo, Tuula Auvinen, Juha Koskimäki, Janne J. Hörkkö, Sohvi 2021 application/pdf 170-181 fulltext http://urn.fi/URN:NBN:fi:jyu-202105102691 eng eng The American Association of Immunologists ImmunoHorizons 2573-7732 4 5 10.4049/immunohorizons.2100014 Mella, M. A., Lavrinienko, A., Akhi, R., Hindström, R., Nissinen, A. E., Wang, C., Kullaa, A., Salo, T., Auvinen, J., Koskimäki, J. J., & Hörkkö, S. (2021). Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota. ImmunoHorizons , 5 (4), 170-181. https://doi.org/10.4049/immunohorizons.2100014 CONVID_68784236 URN:NBN:fi:jyu-202105102691 http://urn.fi/URN:NBN:fi:jyu-202105102691 CC BY-NC-ND 4.0 © 2021 the Authors openAccess https://creativecommons.org/licenses/by-nc-nd/4.0/ immunologia mikrobisto vasta-aineet immuunivajausoireyhtymät limakalvot suu article http://purl.org/eprint/type/JournalArticle http://purl.org/coar/resource_type/c_2df8fbb1 publishedVersion A1 2021 ftjyvaeskylaenun 2024-04-23T23:38:28Z IgA is the most abundant Ab in the human body. However, most patients with selective IgA deficiency (SIgAD) are asymptomatic. IgM, and to lesser extent IgG Abs, are generally presumed to compensate for the lack of IgA in SIgAD by multiplying and adopting functions of IgA. We used data from the Northern Finland Birth Cohort 1966 to investigate whether SIgAD patients have differences in levels of natural Abs to oxidized epitopes compared with 20 randomly selected healthy controls. First, we screened the saliva and serum samples from the Northern Finland Birth Cohort 1966 cohort (n = 1610) for IgA concentration. We detected five IgA-deficient subjects, yielding a prevalence of 0.3%, which is consistent with the general prevalence of 0.25% in the Finnish population. To detect natural Abs, we used malondialdehyde acetaldehyde–low-density lipoprotein (MAA–LDL), an Ag known to bind natural Abs. In this study, we show that natural secretory IgM and IgG Abs to MAA–DL were significantly increased in subjects with SIgAD. Given that secretory IgA is an important part of mucosal immune defense and that, in the gut microbiota, dysbiosis with SIgAD patients has been observed, we characterized the oral bacterial microbiota of the subjects with and without SIgAD using high-throughput 16S rRNA gene sequencing. We found no significant alterations in diversity and composition of the oral microbiota in subjects with SIgAD. Our data suggest that increased levels of secretory natural Abs in patients with SIgAD could be a compensatory mechanism, providing alternative first-line defense against infections and adjusting mucosal milieu to maintain a healthy oral microbiota. peerReviewed Article in Journal/Newspaper Northern Finland JYX - Jyväskylä University Digital Archive |
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JYX - Jyväskylä University Digital Archive |
op_collection_id |
ftjyvaeskylaenun |
language |
English |
topic |
immunologia mikrobisto vasta-aineet immuunivajausoireyhtymät limakalvot suu |
spellingShingle |
immunologia mikrobisto vasta-aineet immuunivajausoireyhtymät limakalvot suu Mella, Miia A. Lavrinienko, Anton Akhi, Ramin Hindström, Rasmus Nissinen, Antti E. Wang, Chunguang Kullaa, Arja Salo, Tuula Auvinen, Juha Koskimäki, Janne J. Hörkkö, Sohvi Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota |
topic_facet |
immunologia mikrobisto vasta-aineet immuunivajausoireyhtymät limakalvot suu |
description |
IgA is the most abundant Ab in the human body. However, most patients with selective IgA deficiency (SIgAD) are asymptomatic. IgM, and to lesser extent IgG Abs, are generally presumed to compensate for the lack of IgA in SIgAD by multiplying and adopting functions of IgA. We used data from the Northern Finland Birth Cohort 1966 to investigate whether SIgAD patients have differences in levels of natural Abs to oxidized epitopes compared with 20 randomly selected healthy controls. First, we screened the saliva and serum samples from the Northern Finland Birth Cohort 1966 cohort (n = 1610) for IgA concentration. We detected five IgA-deficient subjects, yielding a prevalence of 0.3%, which is consistent with the general prevalence of 0.25% in the Finnish population. To detect natural Abs, we used malondialdehyde acetaldehyde–low-density lipoprotein (MAA–LDL), an Ag known to bind natural Abs. In this study, we show that natural secretory IgM and IgG Abs to MAA–DL were significantly increased in subjects with SIgAD. Given that secretory IgA is an important part of mucosal immune defense and that, in the gut microbiota, dysbiosis with SIgAD patients has been observed, we characterized the oral bacterial microbiota of the subjects with and without SIgAD using high-throughput 16S rRNA gene sequencing. We found no significant alterations in diversity and composition of the oral microbiota in subjects with SIgAD. Our data suggest that increased levels of secretory natural Abs in patients with SIgAD could be a compensatory mechanism, providing alternative first-line defense against infections and adjusting mucosal milieu to maintain a healthy oral microbiota. peerReviewed |
format |
Article in Journal/Newspaper |
author |
Mella, Miia A. Lavrinienko, Anton Akhi, Ramin Hindström, Rasmus Nissinen, Antti E. Wang, Chunguang Kullaa, Arja Salo, Tuula Auvinen, Juha Koskimäki, Janne J. Hörkkö, Sohvi |
author_facet |
Mella, Miia A. Lavrinienko, Anton Akhi, Ramin Hindström, Rasmus Nissinen, Antti E. Wang, Chunguang Kullaa, Arja Salo, Tuula Auvinen, Juha Koskimäki, Janne J. Hörkkö, Sohvi |
author_sort |
Mella, Miia A. |
title |
Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota |
title_short |
Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota |
title_full |
Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota |
title_fullStr |
Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota |
title_full_unstemmed |
Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota |
title_sort |
compensatory igm to the rescue : patients with selective iga deficiency have increased natural igm antibodies to maa–ldl and no changes in oral microbiota |
publisher |
The American Association of Immunologists |
publishDate |
2021 |
url |
http://urn.fi/URN:NBN:fi:jyu-202105102691 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
ImmunoHorizons 2573-7732 4 5 10.4049/immunohorizons.2100014 Mella, M. A., Lavrinienko, A., Akhi, R., Hindström, R., Nissinen, A. E., Wang, C., Kullaa, A., Salo, T., Auvinen, J., Koskimäki, J. J., & Hörkkö, S. (2021). Compensatory IgM to the Rescue : Patients with Selective IgA Deficiency Have Increased Natural IgM Antibodies to MAA–LDL and No Changes in Oral Microbiota. ImmunoHorizons , 5 (4), 170-181. https://doi.org/10.4049/immunohorizons.2100014 CONVID_68784236 URN:NBN:fi:jyu-202105102691 http://urn.fi/URN:NBN:fi:jyu-202105102691 |
op_rights |
CC BY-NC-ND 4.0 © 2021 the Authors openAccess https://creativecommons.org/licenses/by-nc-nd/4.0/ |
_version_ |
1799486023273545728 |