Influence of breed and environment on leukocyte telomere length in cattle

High milk yield is associated with reduced longevity in high-producing dairy cattle breeds. Pre-term culling leads to high replacement heifer demand and economic losses for the dairy industry. Selection for this trait is limited because of low heritability and difficulties in phenotype measurement....

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Main Authors: N. S. Yudin, A. V. Igoshin, G. A. Romashov, A. A. Martynov, D. M. Larkin, Н. С. Юдин, А. В. Игошин, Г. А. Ромашов, А. А. Мартынов, Д. М. Ларкин
Other Authors: The work was supported by the Russian Scientific Foundation (RSF) grant No. 22-26-00143 (https://rscf.ru/project/22-26-00143/).
Format: Article in Journal/Newspaper
Language:English
Published: Institute of Cytology and Genetics of Siberian Branch of the RAS 2024
Subjects:
длина теломер лейкоцитов
selection
cattle
breed
dairy
beef
environment
cold climate
leukocyte telomere length
селекция
крупный рогатый скот
молочный
мясной
холодный климат
Sakha
Republic of Sakha
Online Access:https://vavilov.elpub.ru/jour/article/view/4089
https://doi.org/10.18699/vjgb-24-23
id ftjvavilov:oai:oai.vavilov.elpub.ru:article/4089
record_format openpolar
institution Open Polar
collection Vavilov Journal of Genetics and Breeding
op_collection_id ftjvavilov
language English
topic длина теломер лейкоцитов
selection
cattle
breed
dairy
beef
environment
cold climate
leukocyte telomere length
селекция
крупный рогатый скот
молочный
мясной
холодный климат
spellingShingle длина теломер лейкоцитов
selection
cattle
breed
dairy
beef
environment
cold climate
leukocyte telomere length
селекция
крупный рогатый скот
молочный
мясной
холодный климат
N. S. Yudin
A. V. Igoshin
G. A. Romashov
A. A. Martynov
D. M. Larkin
Н. С. Юдин
А. В. Игошин
Г. А. Ромашов
А. А. Мартынов
Д. М. Ларкин
Influence of breed and environment on leukocyte telomere length in cattle
topic_facet длина теломер лейкоцитов
selection
cattle
breed
dairy
beef
environment
cold climate
leukocyte telomere length
селекция
крупный рогатый скот
молочный
мясной
холодный климат
description High milk yield is associated with reduced longevity in high-producing dairy cattle breeds. Pre-term culling leads to high replacement heifer demand and economic losses for the dairy industry. Selection for this trait is limited because of low heritability and difficulties in phenotype measurement. Telomeres are elements found at the ends of chromosomes, consisting of repetitive DNA sequences, several thousand base pairs in length, coupled with nucleoprotein complexes. Eventually, in humans and most other animals, telomere length reduces with age. When telomeric DNA is truncated to a critical length, cell ageing, cell cycle arrest, and apoptosis are induced. As a result, telomere length can be considered as a predictor of health risks and an individual’s lifespan. The leukocyte telomere length may be used as a proxy phenotype of productive lifespan to improve cattle selection. Our objectives were to assess the effects of breed and breed group (dairy vs. beef) on the leukocyte telomere length and to estimate the effect of cold climate on this trait in Kalmyk cattle populations from the South (Rostov Oblast) and Far North (Republic of Sakha) regions of Russia. The leukocyte telomere lengths were estimated computationally from whole-genome resequencing data. We leveraged data on leukocyte telomere length, sex, and age of 239 animals from 17 cattle breeds. The breed factor had a significant effect on leukocyte telomere length across our sample. There was no difference in leukocyte telomere length between dairy and beef groups. The population factor had a significant effect on leukocyte telomere length in Kalmyk animals. In conclusion, we found that breed, but not breed group (dairy vs. beef), was significantly associated with leukocyte telomere length in cattle. Residence in colder climates was associated with longer leukocyte telomere length in Kalmyk breed cattle. Высокие удои молока сопряжены с сокращением продолжительности жизни у высокопродуктивных молочных пород скота. Преждевременная выбраковка приводит к ...
author2 The work was supported by the Russian Scientific Foundation (RSF) grant No. 22-26-00143 (https://rscf.ru/project/22-26-00143/).
format Article in Journal/Newspaper
author N. S. Yudin
A. V. Igoshin
G. A. Romashov
A. A. Martynov
D. M. Larkin
Н. С. Юдин
А. В. Игошин
Г. А. Ромашов
А. А. Мартынов
Д. М. Ларкин
author_facet N. S. Yudin
A. V. Igoshin
G. A. Romashov
A. A. Martynov
D. M. Larkin
Н. С. Юдин
А. В. Игошин
Г. А. Ромашов
А. А. Мартынов
Д. М. Ларкин
author_sort N. S. Yudin
title Influence of breed and environment on leukocyte telomere length in cattle
title_short Influence of breed and environment on leukocyte telomere length in cattle
title_full Influence of breed and environment on leukocyte telomere length in cattle
title_fullStr Influence of breed and environment on leukocyte telomere length in cattle
title_full_unstemmed Influence of breed and environment on leukocyte telomere length in cattle
title_sort influence of breed and environment on leukocyte telomere length in cattle
publisher Institute of Cytology and Genetics of Siberian Branch of the RAS
publishDate 2024
url https://vavilov.elpub.ru/jour/article/view/4089
https://doi.org/10.18699/vjgb-24-23
geographic Sakha
geographic_facet Sakha
genre Republic of Sakha
genre_facet Republic of Sakha
op_source Vavilov Journal of Genetics and Breeding; Том 28, № 2 (2024); 190-197
Вавиловский журнал генетики и селекции; Том 28, № 2 (2024); 190-197
2500-3259
10.18699/vjgb-24-15
op_relation https://vavilov.elpub.ru/jour/article/view/4089/1826
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Burraco P., Hernandez-Gonzalez M., Metcalfe N.B., Monaghan P. Ageing across the great divide: tissue transformation, organismal growth and temperature shape telomere dynamics through the metamorphic transition. Proc. Biol. Sci. 2023;290(1992):20222448. DOI 10.1098/rspb.2022.2448
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op_doi https://doi.org/10.18699/vjgb-24-2310.18699/vjgb-24-1510.1146/annurev-10.1534/genetics.116.10.26717/BJSTR.10.1016/j.arr.10.1073/pnas.
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spelling ftjvavilov:oai:oai.vavilov.elpub.ru:article/4089 2024-05-12T08:10:25+00:00 Influence of breed and environment on leukocyte telomere length in cattle Влияние породы и среды на длину теломер лейкоцитов у крупного рогатого скота N. S. Yudin A. V. Igoshin G. A. Romashov A. A. Martynov D. M. Larkin Н. С. Юдин А. В. Игошин Г. А. Ромашов А. А. Мартынов Д. М. Ларкин The work was supported by the Russian Scientific Foundation (RSF) grant No. 22-26-00143 (https://rscf.ru/project/22-26-00143/). 2024-04-11 application/pdf https://vavilov.elpub.ru/jour/article/view/4089 https://doi.org/10.18699/vjgb-24-23 eng eng Institute of Cytology and Genetics of Siberian Branch of the RAS https://vavilov.elpub.ru/jour/article/view/4089/1826 Andrew T., Aviv A., Falchi M., Surdulescu G.L., Gardner J.P., Lu X., Kimura M., Kato B.S., Valdes A.M., Spector T.D. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am. J. Hum. Genet. 2006;78(3): 480-486. DOI 10.1086/500052 Armanios M. The role of telomeres in human disease. Annu. Rev. Genomics Hum. Genet. 2022;23:363-381. DOI 10.1146/annurev- genom-010422-091101 Asghar M., Palinauskas V., Zaghdoudi-Allan N., Valkiūnas G., Mukhin A., Platonova E., Färnert A., Bensch S., Hasselquist D. Parallel telomere shortening in multiple body tissues owing to malaria infection. Proc. Biol. Sci. 2016;283(1836):20161184. DOI 10.1098/ rspb.2016.1184 Astuti Y., Wardhana A., Watkins J., Wulaningsih W.; PILAR Research Network. Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis. Environ. Res. 2017;158:480- DOI 10.1016/j.envres.2017.06.038 Behr A.A., Liu K.Z., Liu-Fang G., Nakka P., Ramachandran S. pong: fast analysis and visualization of latent clusters in population genetic data. Bioinformatics. 2016;32(18):2817-2823. DOI 10.1093/ bioinformatics/btw327 Ben-Shachar M.S., Lüdecke D., Makowski D. effectsize: Estimation of effect size indices and standardized parameters. J. Open Source Softw. 2020;5(56):2815. DOI 10.21105/joss.02815 Blackburn E.H., Epel E.S., Lin J. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science. 2015;350(6265):1193-1198. DOI 10.1126/science.aab3389 Broer L., Codd V., Nyholt D.R., Deelen J., Mangino M., Willemsen G., Albrecht E., … Vink J.M., Spector T.D., Slagboom P.E., Martin N.G., Samani N.J., van Duijn C.M., Boomsma D.I. Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur. J. Hum. Genet. 2013;21(10):1163-1168. DOI 10.1038/ejhg.2012.303 Brown D.E., Dechow C.D., Liu W.S., Harvatine K.J., Ott T.L. Hot topic: association of telomere length with age, herd, and culling in lactating Holsteins. J. Dairy Sci. 2012;95(11):6384-6387. DOI 10.3168/jds.2012-5593 Burraco P., Hernandez-Gonzalez M., Metcalfe N.B., Monaghan P. Ageing across the great divide: tissue transformation, organismal growth and temperature shape telomere dynamics through the metamorphic transition. Proc. Biol. Sci. 2023;290(1992):20222448. DOI 10.1098/rspb.2022.2448 Carrillo A.E., Flouris A.D. Caloric restriction and longevity: effects of reduced body temperature. Ageing Res. Rev. 2011;10(1):153-162. DOI 10.1016/j.arr.2010.10.001 Chakravarti D., LaBella K.A., DePinho R.A. Telomeres: history, health, and hallmarks of aging. Cell. 2021;184(2):306-322. DOI 10.1016/ j.cell.2020.12.028 Chatelain M., Drobniak S.M., Szulkin M. The association between stressors and telomeres in non-human vertebrates: a meta-analysis. Ecol. Lett. 2020;23(2):381-398. DOI 10.1111/ele.13426 Chik H.Y.J., Sparks A.M., Schroeder J., Dugdale H.L. A meta-analysis on the heritability of vertebrate telomere length. J. Evol. Biol. ;35(10):1283-1295. DOI 10.1111/jeb.14071 Conti B., Sanchez-Alavez M., Winsky-Sommerer R., Morale M.C., Lucero J., Brownell S., Fabre V., Huitron-Resendiz S., Henriksen S., Zorrilla E.P., de Lecea L., Bartfai T. Transgenic mice with a reduced core body temperature have an increased life span. Science. 2006; (5800):825-828. DOI 10.1126/science.1132191 Cook D.E., Zdraljevic S., Tanny R.E., Seo B., Riccardi D.D., Noble L.M., Rockman M.V., Alkema M.J., Braendle C., Kammenga J.E., Wang J., Kruglyak L., Félix M.A., Lee J., Andersen E.C. The genetic basis of natural variation in Caenorhabditis elegans telomere length. Genetics. 2016;204(1):371-383. DOI 10.1534/genetics.116. 191148 Crocco P., De Rango F., Dato S., Rose G., Passarino G. Telomere length as a function of age at population level parallels human survival curves. Aging (Albany NY ). 2021;13(1):204-218. DOI 10.18632/ aging.202498 de Lange T. Shelterin-mediated telomere protection. Annu. Rev. Genet. 2018;52:223-247. 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Vavilov Journal of Genetics and Breeding; Том 28, № 2 (2024); 190-197 Вавиловский журнал генетики и селекции; Том 28, № 2 (2024); 190-197 2500-3259 10.18699/vjgb-24-15 длина теломер лейкоцитов selection cattle breed dairy beef environment cold climate leukocyte telomere length селекция крупный рогатый скот молочный мясной холодный климат info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2024 ftjvavilov https://doi.org/10.18699/vjgb-24-2310.18699/vjgb-24-1510.1146/annurev-10.1534/genetics.116.10.26717/BJSTR.10.1016/j.arr.10.1073/pnas. 2024-04-14T23:45:13Z High milk yield is associated with reduced longevity in high-producing dairy cattle breeds. Pre-term culling leads to high replacement heifer demand and economic losses for the dairy industry. Selection for this trait is limited because of low heritability and difficulties in phenotype measurement. Telomeres are elements found at the ends of chromosomes, consisting of repetitive DNA sequences, several thousand base pairs in length, coupled with nucleoprotein complexes. Eventually, in humans and most other animals, telomere length reduces with age. When telomeric DNA is truncated to a critical length, cell ageing, cell cycle arrest, and apoptosis are induced. As a result, telomere length can be considered as a predictor of health risks and an individual’s lifespan. The leukocyte telomere length may be used as a proxy phenotype of productive lifespan to improve cattle selection. Our objectives were to assess the effects of breed and breed group (dairy vs. beef) on the leukocyte telomere length and to estimate the effect of cold climate on this trait in Kalmyk cattle populations from the South (Rostov Oblast) and Far North (Republic of Sakha) regions of Russia. The leukocyte telomere lengths were estimated computationally from whole-genome resequencing data. We leveraged data on leukocyte telomere length, sex, and age of 239 animals from 17 cattle breeds. The breed factor had a significant effect on leukocyte telomere length across our sample. There was no difference in leukocyte telomere length between dairy and beef groups. The population factor had a significant effect on leukocyte telomere length in Kalmyk animals. In conclusion, we found that breed, but not breed group (dairy vs. beef), was significantly associated with leukocyte telomere length in cattle. Residence in colder climates was associated with longer leukocyte telomere length in Kalmyk breed cattle. Высокие удои молока сопряжены с сокращением продолжительности жизни у высокопродуктивных молочных пород скота. Преждевременная выбраковка приводит к ... Article in Journal/Newspaper Republic of Sakha Vavilov Journal of Genetics and Breeding Sakha

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