VKORC1 gene -1639 G/A and 1173 C/Т polymorphisms in Nenets autonomous district indigenous population
According to the data obtained the VKORC1 gene polymorphism prevalence in the native population of the Nenets autonomous region differed significantly from that in the Arkhangelsk population. The homozygous form of 1173T allele prevailed in the nenets. This may be protective against thrombosis but i...
Published in: | The Scientific Notes of the I. P. Pavlov St. Petersburg State Medical University |
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Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | Russian |
Published: |
Academician I.P. Pavlov First St. Petersburg State Medical University
2014
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Subjects: | |
Online Access: | https://www.sci-notes.ru/jour/article/view/38 https://doi.org/10.24884/1607-4181-2014-21-2-33-36 |
Summary: | According to the data obtained the VKORC1 gene polymorphism prevalence in the native population of the Nenets autonomous region differed significantly from that in the Arkhangelsk population. The homozygous form of 1173T allele prevailed in the nenets. This may be protective against thrombosis but it increases the risk of artery calcification and of indirect overdosing of anticoagulants. По данным исследования, распространенность полиморфизмов гена VKORC1 в популяции коренных жителей Ненецкого автономного округа значительно отличается от таковой у жителей г. Архангельска. У ненцев преобладал аллель 1173Т в гомозиготной форме, что может оказывать протективный эффект по отношению к тромбозам, но повышает риск кальцификации стенок артерий и передозировки непрямыми антикоагулянтами. |
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