Investigator Argus X-12 study on the population of northern Croatia
Abstract X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage g...
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Sociedade Brasileira de Genética
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ftjscielo:oai:scielo:S1415-47572017000100080 2023-05-15T16:31:11+02:00 Investigator Argus X-12 study on the population of northern Croatia Crnjac,Josip Ozretić,Petar Merkaš,Siniša Ratko,Martina Lozančić,Mateja Korolija,Marina Popović,Maja Mršić,Gordan 2017-03-01 text/html http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000100080 en eng Sociedade Brasileira de Genética 10.1590/1678-4685-gmb-2015-0261 info:eu-repo/semantics/openAccess Genetics and Molecular Biology v.40 n.1 2017 X-STR forensic genetics Investigator® Argus X-12 population genetics northern Croatia info:eu-repo/semantics/article 2017 ftjscielo 2017-11-12T16:38:33Z Abstract X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LGs). In this study, we analyzed by capillary electrophoresis blood samples from 100 females and 102 males from a population of northern Croatia. Statistical analysis included calculation of allele and haplotype frequencies, as well as forensic parameters. The most informative marker for the northern Croatia population was DXS10135 with PIC=0.9211 and a total of 27 alleles. The least polymorphic marker was DXS8378 with 6 alleles. The proportion of observed haplotypes from the number of possible haplotypes varied from 2.74–8.57% across all LGs, with LG1 being the most informative. Of the 11 tested world populations compared to the population of northern Croatia, significant differences in genetic distance (FST) were found for Greenlandic and all non-European populations. We found that all tested markers are in HWE and can thus be used for match probability calculation. Because of high combined power of discrimination in both men and women, Investigator® Argus X-12 is applicable for the northern Croatia population in routine forensic casework. Article in Journal/Newspaper greenlandic SciELO Brazil (Scientific Electronic Library Online) |
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Open Polar |
collection |
SciELO Brazil (Scientific Electronic Library Online) |
op_collection_id |
ftjscielo |
language |
English |
topic |
X-STR forensic genetics Investigator® Argus X-12 population genetics northern Croatia |
spellingShingle |
X-STR forensic genetics Investigator® Argus X-12 population genetics northern Croatia Crnjac,Josip Ozretić,Petar Merkaš,Siniša Ratko,Martina Lozančić,Mateja Korolija,Marina Popović,Maja Mršić,Gordan Investigator Argus X-12 study on the population of northern Croatia |
topic_facet |
X-STR forensic genetics Investigator® Argus X-12 population genetics northern Croatia |
description |
Abstract X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LGs). In this study, we analyzed by capillary electrophoresis blood samples from 100 females and 102 males from a population of northern Croatia. Statistical analysis included calculation of allele and haplotype frequencies, as well as forensic parameters. The most informative marker for the northern Croatia population was DXS10135 with PIC=0.9211 and a total of 27 alleles. The least polymorphic marker was DXS8378 with 6 alleles. The proportion of observed haplotypes from the number of possible haplotypes varied from 2.74–8.57% across all LGs, with LG1 being the most informative. Of the 11 tested world populations compared to the population of northern Croatia, significant differences in genetic distance (FST) were found for Greenlandic and all non-European populations. We found that all tested markers are in HWE and can thus be used for match probability calculation. Because of high combined power of discrimination in both men and women, Investigator® Argus X-12 is applicable for the northern Croatia population in routine forensic casework. |
format |
Article in Journal/Newspaper |
author |
Crnjac,Josip Ozretić,Petar Merkaš,Siniša Ratko,Martina Lozančić,Mateja Korolija,Marina Popović,Maja Mršić,Gordan |
author_facet |
Crnjac,Josip Ozretić,Petar Merkaš,Siniša Ratko,Martina Lozančić,Mateja Korolija,Marina Popović,Maja Mršić,Gordan |
author_sort |
Crnjac,Josip |
title |
Investigator Argus X-12 study on the population of northern Croatia |
title_short |
Investigator Argus X-12 study on the population of northern Croatia |
title_full |
Investigator Argus X-12 study on the population of northern Croatia |
title_fullStr |
Investigator Argus X-12 study on the population of northern Croatia |
title_full_unstemmed |
Investigator Argus X-12 study on the population of northern Croatia |
title_sort |
investigator argus x-12 study on the population of northern croatia |
publisher |
Sociedade Brasileira de Genética |
publishDate |
2017 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000100080 |
genre |
greenlandic |
genre_facet |
greenlandic |
op_source |
Genetics and Molecular Biology v.40 n.1 2017 |
op_relation |
10.1590/1678-4685-gmb-2015-0261 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1766020958003396608 |