POPULATION-BASED ASSESSMENT OF THE RECTAL CANCER STAGE STRUCTURE AND INCIDENCE AFTER IMPLEMENTATION OF THE NATIONAL PROJECT “HEALTH” AND ALL-NATIONAL DISPENSARIZATION IN THE ARKHANGELSK REGION, RUSSIA (THE RESULTS OF THE PRELIMINARY STUDY)

Objective. Assessment of the rectal cancer (RC) incidence and stage structure trends in the Arkhangelsk region (AR), Russia before and after implementation of national programs for health system reforming based on population data of the Arkhangelsk Regional Cancer Registry (ARCR) over the period 200...

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Published in:Research'n Practical Medicine Journal
Main Authors: D. M. Dubovichenko, M. Y. Valkov, A. A. Karpunov, A. Yu. Pankrat'eva, Д. М. Дубовиченко, М. Ю. Вальков, А. А. Карпунов, А. Ю. Панкратьева
Format: Article in Journal/Newspaper
Language:Russian
Published: "QUASAR", LLC 2017
Subjects:
Online Access:https://www.rpmj.ru/rpmj/article/view/198
https://doi.org/10.17709/2409-2231-2017-4-3-3
id ftjrpmj:oai:oai.rpmj.elpub.ru:article/198
record_format openpolar
institution Open Polar
collection Research'n Practical Medicine Journal
op_collection_id ftjrpmj
language Russian
topic диспансеризация определенных групп взрослого населения
cancer registry
incidence
stage
National Program “Health”
All-national Dispensarization
канцер-регистр
заболеваемость
стадия
Национальный проект «Здоровье»
spellingShingle диспансеризация определенных групп взрослого населения
cancer registry
incidence
stage
National Program “Health”
All-national Dispensarization
канцер-регистр
заболеваемость
стадия
Национальный проект «Здоровье»
D. M. Dubovichenko
M. Y. Valkov
A. A. Karpunov
A. Yu. Pankrat'eva
Д. М. Дубовиченко
М. Ю. Вальков
А. А. Карпунов
А. Ю. Панкратьева
POPULATION-BASED ASSESSMENT OF THE RECTAL CANCER STAGE STRUCTURE AND INCIDENCE AFTER IMPLEMENTATION OF THE NATIONAL PROJECT “HEALTH” AND ALL-NATIONAL DISPENSARIZATION IN THE ARKHANGELSK REGION, RUSSIA (THE RESULTS OF THE PRELIMINARY STUDY)
topic_facet диспансеризация определенных групп взрослого населения
cancer registry
incidence
stage
National Program “Health”
All-national Dispensarization
канцер-регистр
заболеваемость
стадия
Национальный проект «Здоровье»
description Objective. Assessment of the rectal cancer (RC) incidence and stage structure trends in the Arkhangelsk region (AR), Russia before and after implementation of national programs for health system reforming based on population data of the Arkhangelsk Regional Cancer Registry (ARCR) over the period 2000–2015.Materials and methods. Anonymized data on all cases of RC (C19.0‑C21.0) in the AR in 2000–2015 were extracted from the database of the ARCR. Over the study period, 3721 cases of the RC were selected. Age-standardized (ASR) RC incidence rate was calculated. Population number and its age distribution were taken from the Regional Bureau of Statistics, Arkhangelskstat. Time trends were analyzed using segmented regression.Results. Over the period, an incidence (ASR) of RC in AR increased from 11.5 to 14.2 per 100000. The incidence rates in the male population were higher than in women: 20.3 vs 12.6 in 2015. The growing trend of male incidence was stable. The ASR of RC incidence in female increased significantly by 4.6% per year in 2011–2015. RC ASRs for both urban and rural populations were growing, 12.3 and 20.4 per 100000 in 2015, respectively. StagesI, II, III and IV were established in 14%, 50%, 9% and 21% of cases, however, the stage I in urban residents was detected 4% more often. The proportion of stage I non-significantly varied from 10.6% to 13.3% in 2000–2015. After the introduction of the National Project “Health”, the proportion of the stage IV non-significantly decreased by 5.4% per year, same after the introduction of the All-national Dispensarization it non-significantly increased by 5.4% per year.Conclusion. Implementation of national programs for health system reforming didn’t provide significant improvement in earlier detection of RC. Introduction of national screening programs is necessary. A higher incidence rates among males and rural population require detailed analysis. Цель. Оценка динамики заболеваемости и стадийной структуры злокачественных опухолей прямой кишки (РПК) в Архангельской ...
format Article in Journal/Newspaper
author D. M. Dubovichenko
M. Y. Valkov
A. A. Karpunov
A. Yu. Pankrat'eva
Д. М. Дубовиченко
М. Ю. Вальков
А. А. Карпунов
А. Ю. Панкратьева
author_facet D. M. Dubovichenko
M. Y. Valkov
A. A. Karpunov
A. Yu. Pankrat'eva
Д. М. Дубовиченко
М. Ю. Вальков
А. А. Карпунов
А. Ю. Панкратьева
author_sort D. M. Dubovichenko
title POPULATION-BASED ASSESSMENT OF THE RECTAL CANCER STAGE STRUCTURE AND INCIDENCE AFTER IMPLEMENTATION OF THE NATIONAL PROJECT “HEALTH” AND ALL-NATIONAL DISPENSARIZATION IN THE ARKHANGELSK REGION, RUSSIA (THE RESULTS OF THE PRELIMINARY STUDY)
title_short POPULATION-BASED ASSESSMENT OF THE RECTAL CANCER STAGE STRUCTURE AND INCIDENCE AFTER IMPLEMENTATION OF THE NATIONAL PROJECT “HEALTH” AND ALL-NATIONAL DISPENSARIZATION IN THE ARKHANGELSK REGION, RUSSIA (THE RESULTS OF THE PRELIMINARY STUDY)
title_full POPULATION-BASED ASSESSMENT OF THE RECTAL CANCER STAGE STRUCTURE AND INCIDENCE AFTER IMPLEMENTATION OF THE NATIONAL PROJECT “HEALTH” AND ALL-NATIONAL DISPENSARIZATION IN THE ARKHANGELSK REGION, RUSSIA (THE RESULTS OF THE PRELIMINARY STUDY)
title_fullStr POPULATION-BASED ASSESSMENT OF THE RECTAL CANCER STAGE STRUCTURE AND INCIDENCE AFTER IMPLEMENTATION OF THE NATIONAL PROJECT “HEALTH” AND ALL-NATIONAL DISPENSARIZATION IN THE ARKHANGELSK REGION, RUSSIA (THE RESULTS OF THE PRELIMINARY STUDY)
title_full_unstemmed POPULATION-BASED ASSESSMENT OF THE RECTAL CANCER STAGE STRUCTURE AND INCIDENCE AFTER IMPLEMENTATION OF THE NATIONAL PROJECT “HEALTH” AND ALL-NATIONAL DISPENSARIZATION IN THE ARKHANGELSK REGION, RUSSIA (THE RESULTS OF THE PRELIMINARY STUDY)
title_sort population-based assessment of the rectal cancer stage structure and incidence after implementation of the national project “health” and all-national dispensarization in the arkhangelsk region, russia (the results of the preliminary study)
publisher "QUASAR", LLC
publishDate 2017
url https://www.rpmj.ru/rpmj/article/view/198
https://doi.org/10.17709/2409-2231-2017-4-3-3
genre Arkhangelsk
Архангельск*
genre_facet Arkhangelsk
Архангельск*
op_source Research and Practical Medicine Journal; Том 4, № 3 (2017); 23-32
Research'n Practical Medicine Journal; Том 4, № 3 (2017); 23-32
2410-1893
10.17709/2409-2231-2017-4-3
op_relation https://www.rpmj.ru/rpmj/article/view/198/190
Haggar FA, Boushey RP. Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors. Clinics in Colon and Rectal Surgery. 2009; 22 (4): 191–197. DOI:10.1055/s‑0029–1242458
GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012 [accessed 15.04.2017]. Available at: http://globocan.iarc.fr/Default.aspx
Amersi F, Agustin M, Ko CY. Colorectal Cancer: Epidemiology, Risk Factors, and Health Services. Clinics in Colon and Rectal Surgery. 2005; 18 (3):133–140. DOI:10.1055/s‑2005–916274
Fung TT, Brown LS. Dietary Patterns and the Risk of Colorectal Cancer. Current nutrition reports. 2013; 2 (1): 48–55. DOI:10.1007/s13668–012–0031–1
Лебедева Л.Н., Красильников А.В., Асахин С.М., Вальков М.Ю. Динамика заболеваемости и смертности при раке ободочной кишки в 2000–2010 годах в Архангельской области (популяционное исследование). Экология человека. 2014; 9:18–23.
Лебедева Л.Н., Вальков М.Ю., Асахин С.М., Красильников А.В. Популяционная характеристика рака ободочной кишки в Архангельской области России по данным регионального ракового регистра [Электронный ресурс]. Вестник Российского научного центра рентгенорадиологии Минздрава России. 2014; 1: 6.
Janout V, Kollárová H. Epidemiology of colorectal cancer. Biomed Pap Med FacUnivPalacku Olomouc Czech Repub. 2009; 145: 5–10.
Boyle P, Ferlay J. Mortality and survival in breast and colorectal cancer. Nat Clin Pract Oncol. 2005; 2 (9): 424–425. DOI:10.1038/ncponc0288
Каприн А.Д., Старинский В.В., Петрова Г. В. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена филиал ФГБУ «НМИРЦ» Минздрава России. 2017. Доступно: http://www.oncology.ru/service/statistics/malignant_tumors/2015.pdf [дата обращения 15.04.2017].
Татьяна Голикова: Здоровье должно стать приоритетом в системе национальных ценностей. Доступно: http://www.medvestnik.ru/archive/tatyana_golikova_zdorove_dolzhno_stat_prioritetom_v_sisteme_socialnyh_cennostey.html [дата обращения 15.04.2017].
Vaktskjold A, Lebedintseva JA, Korotov DS. Cancer incidence in Arkhangelskaja Oblast in Northwestern Russia. The Arkhangelsk Cancer Registry. BMC Cancer. 2005; 5: 82. DOI:10.1186/1471–2407–5-82
Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD‑2). Lancet (London, England). 2015; 385 (9972): 977–1010. DOI:10.1016/S0140–6736 (14)62038–9
Geiger TM, Ricciardi R. Screening Options and Recommendations for Colorectal Cancer. Clinics in Colon and Rectal Surgery. 2009; 22 (4): 209–217. DOI:10.1055/s‑0029–1242460
Doubeni CA, Weinmann S, Adams K. Screening colonoscopy and risk of incident late-stage colorectal cancer diagnosis in average-risk adults: a nested case-control study. Ann Intern Med. 2013 Mar 5;158 (5 Pt 1):312–20. DOI:10.7326/0003–4819–158–5-201303050–00003
Pathy S, Lambert R, Sauvaget C, Sankaranarayanan R. The incidence and survival rates of colorectal cancer in India remain low compared with rising rates in East Asia. Dis Colon Rectum. 2012; 55 (8): 900–6. DOI:10.1097/DCR.0b013e31825afc4e
Kinney AY, Harrell J, Slattery M, Martin C, Sandler RS. Rural-urban differences in colon cancer risk in blacks and whites: the North Carolina Colon Cancer Study. J Rural Health. 2006; 22 (2): 124–30
Chow CJ, Al-Refaie WB, Abraham A. Does Patient Rurality Predict Quality Colon Cancer Care? A Population Based Study. Diseases of the colon and rectum. 2015; 58 (4): 415–422. DOI:10.1097/DCR.0000000000000173
Bretthauer M. Evidence for colorectal cancer screening. Best Practice & Research Clinical Gastroenterology. 2010; 24: 417–425. DOI:10.1016/j.bpg.2010.06.005
El Zoghbi M, Cummings LC. New era of colorectal cancer screening. World J Gastrointest Endosc. 2016 Mar 10;8 (5):252–8. DOI:10.4253/wjge.v8.i5.252
https://www.rpmj.ru/rpmj/article/view/198
doi:10.17709/2409-2231-2017-4-3-3
op_rights Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).The Publishing contract completed and signed by all the authors of the article, should be sent to the editorial board together with the article.
Авторы, публикующие в данном журнале, соглашаются со следующим: а. Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License, которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале. b. Авторы сохраняют право заключать отдельные контрактные договоренности, касающиеся не-эксклюзивного распространения версии работы в опубликованном здесь виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию в этом журнале. c. Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению
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spelling ftjrpmj:oai:oai.rpmj.elpub.ru:article/198 2024-09-15T17:54:43+00:00 POPULATION-BASED ASSESSMENT OF THE RECTAL CANCER STAGE STRUCTURE AND INCIDENCE AFTER IMPLEMENTATION OF THE NATIONAL PROJECT “HEALTH” AND ALL-NATIONAL DISPENSARIZATION IN THE ARKHANGELSK REGION, RUSSIA (THE RESULTS OF THE PRELIMINARY STUDY) ПОПУЛЯЦИОННАЯ ОЦЕНКА ДИНАМИКИ ЗАБОЛЕВАЕМОСТИ И СТАДИЙНОЙ СТРУКТУРЫ РАКА ПРЯМОЙ КИШКИ В УСЛОВИЯХ РЕАЛИЗАЦИИ МЕРОПРИЯТИЙ НАЦИОНАЛЬНОГО ПРОЕКТА «ЗДОРОВЬЕ» И ДИСПАНСЕРИЗАЦИИ ОПРЕДЕЛЕННЫХ ГРУПП ВЗРОСЛОГО НАСЕЛЕНИЯ В АРХАНГЕЛЬСКОЙ ОБЛАСТИ (ИТОГИ ПРЕДВАРИТЕЛЬНОГО ИССЛЕДОВАНИЯ) D. M. Dubovichenko M. Y. Valkov A. A. Karpunov A. Yu. Pankrat'eva Д. М. Дубовиченко М. Ю. Вальков А. А. Карпунов А. Ю. Панкратьева 2017-09-20 application/pdf https://www.rpmj.ru/rpmj/article/view/198 https://doi.org/10.17709/2409-2231-2017-4-3-3 rus rus "QUASAR", LLC https://www.rpmj.ru/rpmj/article/view/198/190 Haggar FA, Boushey RP. Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors. Clinics in Colon and Rectal Surgery. 2009; 22 (4): 191–197. DOI:10.1055/s‑0029–1242458 GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012 [accessed 15.04.2017]. Available at: http://globocan.iarc.fr/Default.aspx Amersi F, Agustin M, Ko CY. Colorectal Cancer: Epidemiology, Risk Factors, and Health Services. Clinics in Colon and Rectal Surgery. 2005; 18 (3):133–140. DOI:10.1055/s‑2005–916274 Fung TT, Brown LS. Dietary Patterns and the Risk of Colorectal Cancer. Current nutrition reports. 2013; 2 (1): 48–55. DOI:10.1007/s13668–012–0031–1 Лебедева Л.Н., Красильников А.В., Асахин С.М., Вальков М.Ю. Динамика заболеваемости и смертности при раке ободочной кишки в 2000–2010 годах в Архангельской области (популяционное исследование). Экология человека. 2014; 9:18–23. Лебедева Л.Н., Вальков М.Ю., Асахин С.М., Красильников А.В. Популяционная характеристика рака ободочной кишки в Архангельской области России по данным регионального ракового регистра [Электронный ресурс]. Вестник Российского научного центра рентгенорадиологии Минздрава России. 2014; 1: 6. Janout V, Kollárová H. Epidemiology of colorectal cancer. Biomed Pap Med FacUnivPalacku Olomouc Czech Repub. 2009; 145: 5–10. Boyle P, Ferlay J. Mortality and survival in breast and colorectal cancer. Nat Clin Pract Oncol. 2005; 2 (9): 424–425. DOI:10.1038/ncponc0288 Каприн А.Д., Старинский В.В., Петрова Г. В. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена филиал ФГБУ «НМИРЦ» Минздрава России. 2017. Доступно: http://www.oncology.ru/service/statistics/malignant_tumors/2015.pdf [дата обращения 15.04.2017]. Татьяна Голикова: Здоровье должно стать приоритетом в системе национальных ценностей. Доступно: http://www.medvestnik.ru/archive/tatyana_golikova_zdorove_dolzhno_stat_prioritetom_v_sisteme_socialnyh_cennostey.html [дата обращения 15.04.2017]. Vaktskjold A, Lebedintseva JA, Korotov DS. Cancer incidence in Arkhangelskaja Oblast in Northwestern Russia. The Arkhangelsk Cancer Registry. BMC Cancer. 2005; 5: 82. DOI:10.1186/1471–2407–5-82 Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD‑2). Lancet (London, England). 2015; 385 (9972): 977–1010. DOI:10.1016/S0140–6736 (14)62038–9 Geiger TM, Ricciardi R. Screening Options and Recommendations for Colorectal Cancer. Clinics in Colon and Rectal Surgery. 2009; 22 (4): 209–217. DOI:10.1055/s‑0029–1242460 Doubeni CA, Weinmann S, Adams K. Screening colonoscopy and risk of incident late-stage colorectal cancer diagnosis in average-risk adults: a nested case-control study. Ann Intern Med. 2013 Mar 5;158 (5 Pt 1):312–20. DOI:10.7326/0003–4819–158–5-201303050–00003 Pathy S, Lambert R, Sauvaget C, Sankaranarayanan R. The incidence and survival rates of colorectal cancer in India remain low compared with rising rates in East Asia. Dis Colon Rectum. 2012; 55 (8): 900–6. DOI:10.1097/DCR.0b013e31825afc4e Kinney AY, Harrell J, Slattery M, Martin C, Sandler RS. Rural-urban differences in colon cancer risk in blacks and whites: the North Carolina Colon Cancer Study. J Rural Health. 2006; 22 (2): 124–30 Chow CJ, Al-Refaie WB, Abraham A. Does Patient Rurality Predict Quality Colon Cancer Care? A Population Based Study. Diseases of the colon and rectum. 2015; 58 (4): 415–422. DOI:10.1097/DCR.0000000000000173 Bretthauer M. Evidence for colorectal cancer screening. Best Practice & Research Clinical Gastroenterology. 2010; 24: 417–425. DOI:10.1016/j.bpg.2010.06.005 El Zoghbi M, Cummings LC. New era of colorectal cancer screening. World J Gastrointest Endosc. 2016 Mar 10;8 (5):252–8. DOI:10.4253/wjge.v8.i5.252 https://www.rpmj.ru/rpmj/article/view/198 doi:10.17709/2409-2231-2017-4-3-3 Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).The Publishing contract completed and signed by all the authors of the article, should be sent to the editorial board together with the article. Авторы, публикующие в данном журнале, соглашаются со следующим: а. Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License, которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале. b. Авторы сохраняют право заключать отдельные контрактные договоренности, касающиеся не-эксклюзивного распространения версии работы в опубликованном здесь виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию в этом журнале. c. Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению Research and Practical Medicine Journal; Том 4, № 3 (2017); 23-32 Research'n Practical Medicine Journal; Том 4, № 3 (2017); 23-32 2410-1893 10.17709/2409-2231-2017-4-3 диспансеризация определенных групп взрослого населения cancer registry incidence stage National Program “Health” All-national Dispensarization канцер-регистр заболеваемость стадия Национальный проект «Здоровье» info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2017 ftjrpmj https://doi.org/10.17709/2409-2231-2017-4-3-310.17709/2409-2231-2017-4-310.1055/s‑0029–124245810.1055/s‑2005–91627410.1007/s13668–012–0031–110.1038/ncponc028810.1186/1471–2407–5-8210.1016/S0140–673610.1055/s‑0029–124246010.7326/0003–4819–158–5-201303050–0 2024-08-09T03:00:48Z Objective. Assessment of the rectal cancer (RC) incidence and stage structure trends in the Arkhangelsk region (AR), Russia before and after implementation of national programs for health system reforming based on population data of the Arkhangelsk Regional Cancer Registry (ARCR) over the period 2000–2015.Materials and methods. Anonymized data on all cases of RC (C19.0‑C21.0) in the AR in 2000–2015 were extracted from the database of the ARCR. Over the study period, 3721 cases of the RC were selected. Age-standardized (ASR) RC incidence rate was calculated. Population number and its age distribution were taken from the Regional Bureau of Statistics, Arkhangelskstat. Time trends were analyzed using segmented regression.Results. Over the period, an incidence (ASR) of RC in AR increased from 11.5 to 14.2 per 100000. The incidence rates in the male population were higher than in women: 20.3 vs 12.6 in 2015. The growing trend of male incidence was stable. The ASR of RC incidence in female increased significantly by 4.6% per year in 2011–2015. RC ASRs for both urban and rural populations were growing, 12.3 and 20.4 per 100000 in 2015, respectively. StagesI, II, III and IV were established in 14%, 50%, 9% and 21% of cases, however, the stage I in urban residents was detected 4% more often. The proportion of stage I non-significantly varied from 10.6% to 13.3% in 2000–2015. After the introduction of the National Project “Health”, the proportion of the stage IV non-significantly decreased by 5.4% per year, same after the introduction of the All-national Dispensarization it non-significantly increased by 5.4% per year.Conclusion. Implementation of national programs for health system reforming didn’t provide significant improvement in earlier detection of RC. Introduction of national screening programs is necessary. A higher incidence rates among males and rural population require detailed analysis. Цель. Оценка динамики заболеваемости и стадийной структуры злокачественных опухолей прямой кишки (РПК) в Архангельской ... Article in Journal/Newspaper Arkhangelsk Архангельск* Research'n Practical Medicine Journal Research'n Practical Medicine Journal 4 3 23 32