Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023

The review provides concise information on the innate ability of cells of the tularemia pathogen, Francisella tularensis subsp. Holarctica, to resist antimicrobials through a variety of mechanisms, leading to its multi-resistance. In total, taking into account new territories, 120 cases of human inf...

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Main Authors: T. Yu. Kudryavtseva, V. P. Popov, A. N. Mokrievich, E. S. Kulikalova, A. V. Kholin, A. V. Mazepa, M. A. Borzenko, N. L. Pichurina, N. V. Pavlovich, A. K. Noskov, D. V. Trankvilevsky, M. V. Khramov, I. A. Dyatlov, Т. Ю. Кудрявцева, В. П. Попов, А. Н. Мокриевич, Е. С. Куликалова, А. В. Холин, А. В. Мазепа, М. А. Борзенко, Н. Л. Пичурина, Н. В. Павлович, А. К. Носков, Д. В. Транквилевский, М. В. Храмов, И. А. Дятлов
Other Authors: Работа выполнена в рамках отраслевой программы Роспотребнадзора и деятельности референс-центра ФБУН ГНЦ ПМБ по мониторингу за туляремией.
Format: Article in Journal/Newspaper
Language:Russian
Published: Russian Research Anti-Plague Institute “Microbe” 2023
Subjects:
иммунопрофилактика
Francisella tularensis
natural foci
epidemic outbreaks
zoological and entomological material
immunoprophylaxis
природные очаги
эпидемические вспышки
зоолого-энтомологический материал
Arkhangelsk
Republic of Karelia
Online Access:https://journal.microbe.ru/jour/article/view/1788
https://doi.org/10.21055/0370-1069-2023-1-37-47
id ftjppdi:oai:oai.microbe.elpub.ru:article/1788
record_format openpolar
institution Open Polar
collection Problems of Particularly Dangerous Infections
op_collection_id ftjppdi
language Russian
topic иммунопрофилактика
Francisella tularensis
natural foci
epidemic outbreaks
zoological and entomological material
immunoprophylaxis
природные очаги
эпидемические вспышки
зоолого-энтомологический материал
spellingShingle иммунопрофилактика
Francisella tularensis
natural foci
epidemic outbreaks
zoological and entomological material
immunoprophylaxis
природные очаги
эпидемические вспышки
зоолого-энтомологический материал
T. Yu. Kudryavtseva
V. P. Popov
A. N. Mokrievich
E. S. Kulikalova
A. V. Kholin
A. V. Mazepa
M. A. Borzenko
N. L. Pichurina
N. V. Pavlovich
A. K. Noskov
D. V. Trankvilevsky
M. V. Khramov
I. A. Dyatlov
Т. Ю. Кудрявцева
В. П. Попов
А. Н. Мокриевич
Е. С. Куликалова
А. В. Холин
А. В. Мазепа
М. А. Борзенко
Н. Л. Пичурина
Н. В. Павлович
А. К. Носков
Д. В. Транквилевский
М. В. Храмов
И. А. Дятлов
Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023
topic_facet иммунопрофилактика
Francisella tularensis
natural foci
epidemic outbreaks
zoological and entomological material
immunoprophylaxis
природные очаги
эпидемические вспышки
зоолого-энтомологический материал
description The review provides concise information on the innate ability of cells of the tularemia pathogen, Francisella tularensis subsp. Holarctica, to resist antimicrobials through a variety of mechanisms, leading to its multi-resistance. In total, taking into account new territories, 120 cases of human infection were registered in the Russian Federation in 2022. Epizootic manifestations of the infection of varying degrees of intensity were detected in 58 constituent entities. Against this background, sporadic cases of tularemia in humans were reported in 18 regions of the country. An outbreak of tularemia occurred in the Stavropol Territory; the disease of mild and moderate severity was found in 76 people. The increased incidence of tularemia persists in the Republic of Karelia with severe cases of the disease in the absence of immunoprophylaxis of this infection in the region. A total of 61 cultures of the tularemia pathogen F. tularensis subsp. holarctica, out of which 20 erythromycin-resistant strains were isolated in the Stavropol Territory. In addition, 8 cultures of F. tularensis subsp. mediasiatica from a silt sample and mites Dermacentor silvarum and Haemaphysalis concinna caught in the Republic of Altai were isolated. On the territory of the Russian Federation in 2022, 930 999 people were vaccinated and revaccinated against tularemia. Based on the analysis of the data obtained in 2022, epidemic complications in 2023 in the form of sporadic cases of the disease among the unvaccinated population are most likely to occur in the territories of the Central Federal District – in the Vladimir, Ryazan and Smolensk Regions; Northwestern Federal District – in the Arkhangelsk Region and the Republic of Karelia; Southern Federal District – in the Volgograd and Rostov Regions. The situation in the North Caucasian Federal District will remain tense in the Stavropol Territory; in the Volga Federal District – in the territories of the Saratov Region, as well as in the Kirov Region and the Republic of Mordovia; Ural Federal ...
author2 Работа выполнена в рамках отраслевой программы Роспотребнадзора и деятельности референс-центра ФБУН ГНЦ ПМБ по мониторингу за туляремией.
format Article in Journal/Newspaper
author T. Yu. Kudryavtseva
V. P. Popov
A. N. Mokrievich
E. S. Kulikalova
A. V. Kholin
A. V. Mazepa
M. A. Borzenko
N. L. Pichurina
N. V. Pavlovich
A. K. Noskov
D. V. Trankvilevsky
M. V. Khramov
I. A. Dyatlov
Т. Ю. Кудрявцева
В. П. Попов
А. Н. Мокриевич
Е. С. Куликалова
А. В. Холин
А. В. Мазепа
М. А. Борзенко
Н. Л. Пичурина
Н. В. Павлович
А. К. Носков
Д. В. Транквилевский
М. В. Храмов
И. А. Дятлов
author_facet T. Yu. Kudryavtseva
V. P. Popov
A. N. Mokrievich
E. S. Kulikalova
A. V. Kholin
A. V. Mazepa
M. A. Borzenko
N. L. Pichurina
N. V. Pavlovich
A. K. Noskov
D. V. Trankvilevsky
M. V. Khramov
I. A. Dyatlov
Т. Ю. Кудрявцева
В. П. Попов
А. Н. Мокриевич
Е. С. Куликалова
А. В. Холин
А. В. Мазепа
М. А. Борзенко
Н. Л. Пичурина
Н. В. Павлович
А. К. Носков
Д. В. Транквилевский
М. В. Храмов
И. А. Дятлов
author_sort T. Yu. Kudryavtseva
title Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023
title_short Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023
title_full Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023
title_fullStr Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023
title_full_unstemmed Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023
title_sort multidrug resistance of f. tularensis subsp. holarctica, epizootiological and epidemiological analysis of the situation on tularemia in the russian federation in 2022 and forecast for 2023
publisher Russian Research Anti-Plague Institute “Microbe”
publishDate 2023
url https://journal.microbe.ru/jour/article/view/1788
https://doi.org/10.21055/0370-1069-2023-1-37-47
genre Arkhangelsk
Republic of Karelia
genre_facet Arkhangelsk
Republic of Karelia
op_source Problems of Particularly Dangerous Infections; № 1 (2023); 37-47
Проблемы особо опасных инфекций; № 1 (2023); 37-47
2658-719X
0370-1069
op_relation https://journal.microbe.ru/jour/article/view/1788/1358
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https://journal.microbe.ru/jour/article/view/1788
doi:10.21055/0370-1069-2023-1-37-47
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op_doi https://doi.org/10.21055/0370-1069-2023-1-37-4710.1371/journal.pone.018355410.1016/j.ddtec.2014.02.00110.1016/j.ijmm.2013.02.00910.4161/viru.2372410.1007/s00203-006-0140-610.1128/AAC.05305-1110.1016/j.ijantimicag.2008.03.01710.1111/mmi.1200410.1073/pnas.1
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spelling ftjppdi:oai:oai.microbe.elpub.ru:article/1788 2024-09-09T19:29:08+00:00 Multidrug Resistance of F. tularensis subsp. holarctica, Epizootiological and Epidemiological Analysis of the Situation on Tularemia in the Russian Federation in 2022 and Forecast for 2023 Множественная лекарственная устойчивость клеток F. tularensis subsp. holarctica, анализ эпизоотологической и эпидемиологической ситуации по туляремии на территории Российской Федерации в 2022 г. и прогноз на 2023 г. T. Yu. Kudryavtseva V. P. Popov A. N. Mokrievich E. S. Kulikalova A. V. Kholin A. V. Mazepa M. A. Borzenko N. L. Pichurina N. V. Pavlovich A. K. Noskov D. V. Trankvilevsky M. V. Khramov I. A. Dyatlov Т. Ю. Кудрявцева В. П. Попов А. Н. Мокриевич Е. С. Куликалова А. В. Холин А. В. Мазепа М. А. Борзенко Н. Л. Пичурина Н. В. Павлович А. К. Носков Д. В. Транквилевский М. В. Храмов И. А. Дятлов Работа выполнена в рамках отраслевой программы Роспотребнадзора и деятельности референс-центра ФБУН ГНЦ ПМБ по мониторингу за туляремией. 2023-04-28 application/pdf https://journal.microbe.ru/jour/article/view/1788 https://doi.org/10.21055/0370-1069-2023-1-37-47 rus rus Russian Research Anti-Plague Institute “Microbe” https://journal.microbe.ru/jour/article/view/1788/1358 Challacombe J.F., Pillai S., Kuske C.R. Shared features of cryptic plasmids from environmental and pathogenic Francisella species. PLoS One. 2017; 12(8):e0183554. DOI:10.1371/journal.pone.0183554. Martinez J.L. General principles of antibiotic resistance in bacteria. Drug Discov. Today. 2014; 11:33–9. DOI:10.1016/j.ddtec.2014.02.001. Cox G., Wright G.D. Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions. Int. J. Med. Microbiol. 2013; 303(6-7):287–92. DOI:10.1016/j.ijmm.2013.02.009. Soto S.M. Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm. Virulence. 2013; 4(3):223–9. DOI:10.4161/viru.23724. Bina X.R., Wang C., Miller M.A., Bina J.E. The Bla2 betalactamase from the live-vaccine strain of Francisella tularensis encodes a functional protein that is only active against penicillin-class beta-lactam antibiotics. Arch. Microbiol. 2006; 186(3):219–28. DOI:10.1007/s00203-006-0140-6. Antunes N.T., Frase H., Toth M., Vakulenko S.B. The class A β-lactamase FTU-1 is native to Francisella tularensis. Antimicrob. Agents Chemother. 2012; 56(2):666–71. DOI:10.1128/AAC.05305-11. Biswas S., Raoult D., Rolain J.M. A bioinformatic approach to understanding antibiotic resistance in intracellular bacteria through whole genome analysis. Int. J. Antimicrob. Agents. 2008; 32(3):207–20. DOI:10.1016/j.ijantimicag.2008.03.017. Bodey G.P. Penicillins, monobactams, and carbapenems. Tex. Heart Inst. J. 1990; 17(4):315–29. Llewellyn A.C., Zhao J., Song F., Parvathareddy J., Xu Q., Napier B.A., Laroui H., Merlin D., Bina J.E., Cotter P.A., Miller M.A., Raetz C.R.H., Weiss D.S. NaxD is a deacetylase required for lipid A modification and Francisella pathogenesis. Mol. Microbiol. 2012; 86(3):611–27. DOI:10.1111/mmi.12004. Li Y., Powell D.A., Shaffer S.A., Rasko D.A., Pelletier M.R., Leszyk J.D., Scott A.J., Masoudie A., Goodlett D.R., Wang X., Raetz C.R.H., Ernst R.K. LPS remodeling is an evolved survival strategy for bacteria. Proc. Natl Acad. Sci. USA. 2012; 109(22):8716–21. DOI:10.1073/pnas.1202908109. Stephens M.D., Hubble V.B., Ernst R.K., van Hoek M.L., Melander R.J., Cavanagh J., Melander C. Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants. Medchemcomm. 2016; 7(1):128–31. DOI:10.1039/C5MD00353A. Karlsson E., Golovliov I., Lärkeryd A., Granberg M., Larsson E., Öhrman C., Niemcewicz M., Birdsell D., Wagner D.M., Forsman M., Johansson A. 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DOI:10.21055/0370-1069-2021-4-105-111. https://journal.microbe.ru/jour/article/view/1788 doi:10.21055/0370-1069-2023-1-37-47 Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). 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Problems of Particularly Dangerous Infections; № 1 (2023); 37-47 Проблемы особо опасных инфекций; № 1 (2023); 37-47 2658-719X 0370-1069 иммунопрофилактика Francisella tularensis natural foci epidemic outbreaks zoological and entomological material immunoprophylaxis природные очаги эпидемические вспышки зоолого-энтомологический материал info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2023 ftjppdi https://doi.org/10.21055/0370-1069-2023-1-37-4710.1371/journal.pone.018355410.1016/j.ddtec.2014.02.00110.1016/j.ijmm.2013.02.00910.4161/viru.2372410.1007/s00203-006-0140-610.1128/AAC.05305-1110.1016/j.ijantimicag.2008.03.01710.1111/mmi.1200410.1073/pnas.1 2024-06-20T03:22:40Z The review provides concise information on the innate ability of cells of the tularemia pathogen, Francisella tularensis subsp. Holarctica, to resist antimicrobials through a variety of mechanisms, leading to its multi-resistance. In total, taking into account new territories, 120 cases of human infection were registered in the Russian Federation in 2022. Epizootic manifestations of the infection of varying degrees of intensity were detected in 58 constituent entities. Against this background, sporadic cases of tularemia in humans were reported in 18 regions of the country. An outbreak of tularemia occurred in the Stavropol Territory; the disease of mild and moderate severity was found in 76 people. The increased incidence of tularemia persists in the Republic of Karelia with severe cases of the disease in the absence of immunoprophylaxis of this infection in the region. A total of 61 cultures of the tularemia pathogen F. tularensis subsp. holarctica, out of which 20 erythromycin-resistant strains were isolated in the Stavropol Territory. In addition, 8 cultures of F. tularensis subsp. mediasiatica from a silt sample and mites Dermacentor silvarum and Haemaphysalis concinna caught in the Republic of Altai were isolated. On the territory of the Russian Federation in 2022, 930 999 people were vaccinated and revaccinated against tularemia. Based on the analysis of the data obtained in 2022, epidemic complications in 2023 in the form of sporadic cases of the disease among the unvaccinated population are most likely to occur in the territories of the Central Federal District – in the Vladimir, Ryazan and Smolensk Regions; Northwestern Federal District – in the Arkhangelsk Region and the Republic of Karelia; Southern Federal District – in the Volgograd and Rostov Regions. The situation in the North Caucasian Federal District will remain tense in the Stavropol Territory; in the Volga Federal District – in the territories of the Saratov Region, as well as in the Kirov Region and the Republic of Mordovia; Ural Federal ... Article in Journal/Newspaper Arkhangelsk Republic of Karelia Problems of Particularly Dangerous Infections

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