Histopathological lesions in mice caused by rabies virus molecular variants circulating in Mexican wildlife
The purpose of this study was to know weather some molecular variants of the rabies virus detected in Mexican wildlife could produce histopathological differences in mouse central nervous system. Five 6-mouse groups were inoculated intracerebrally with three different virus variants isolated from wi...
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Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias
2012
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ftjpecurias:oai:cienciaspecuarias.inifap.gob.mx:article/1401 2023-05-15T18:50:06+02:00 Histopathological lesions in mice caused by rabies virus molecular variants circulating in Mexican wildlife Lesiones histopatológicas producidas con variantes moleculares de fauna silvestre del virus de la rabia que circula en México E.Weimersheimer, José Loza Rubio, Elizabeth Morales Salinas, Elizabeth 2012-01-01 application/pdf https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/1401 spa spa Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/1401/1396 https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/1401 http://creativecommons.org/licenses/by-nc-sa/4.0 CC-BY-NC-SA Revista Mexicana de Ciencias Pecuarias; Vol. 42, Núm. 3 (2004); 411 a 417 2448-6698 2007-1124 Rabies Wild animals Molecular variants Epidemiological cycle Spongiosis Bovine spongiform encephalopathy Rabia Fauna silvestre Variantes moleculares Ciclo epidemiológico Espongiosis Encefalopatía espongiforme bovina info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2012 ftjpecurias 2022-06-07T07:10:55Z The purpose of this study was to know weather some molecular variants of the rabies virus detected in Mexican wildlife could produce histopathological differences in mouse central nervous system. Five 6-mouse groups were inoculated intracerebrally with three different virus variants isolated from wildlife. Group 1) lynx/fox, Group 2) vampire bat, Group 3) skunk, Group 4) challenge virus standard (CVS), Group 5) normal mouse brain (NMB). Animals in Group 4 and those inoculated with all three different isolates resulted positive to the fluorescent antibody test. Animals in Group 1 had lesions characteristic of central nervous system (CNS), such as: inflammation, non-suppurative encephalitis, moderate-to-severe perivascular lymphocytic infiltration affecting only the hippocampus and the thalamic region, intra-cytoplasmic inclusions in the neurons (Negri's corpuscles), mild microgliosis, and spongiosis-like vacuoles of different sizes in the neuropil. Animals in Groups 2 and 3 showed similar lesions, but no spongiosis or Negri's corpuscles. None of the animals showed neuronophagia. No changes were found in Group 5. Differential diagnosis with bovine spongiform encephalopathy (BSE) is recommended, since very similar lesions were observed with the fox/lynx variant. El objetivo de este estudio fue conocer si algunas de las variantes moleculares del virus de la rabia detectadas en México producían diferencias histopatológicas en el sistema nervioso central de ratón. Se formaron cinco grupos con seis ratones cada uno, que se inocularon por vía intracerebral con tres variantes de fauna silvestre. Grupo 1) lince/zorro, Grupo 2) murciélago hematófago, Grupo 3) zorrillo, Grupo 4) virus estándar de desafío (CVS), Grupo 5) cerebro normal de ratón (CNR). El Grupo 4 y los animales inoculados con los tres diferentes aislamientos, resultaron positivos por anticuerpos fluorescentes. El Grupo 1 presentó lesiones características de inflamación en el sistema nerviosos central: encefalitis no supurativa, infiltrado linfocitario ... Article in Journal/Newspaper Lince Lynx Revista Mexicana de Ciencias Pecuarias (Instituto Nacional de Investigaciones Forestales, Agrílas y Pecuarias) |
institution |
Open Polar |
collection |
Revista Mexicana de Ciencias Pecuarias (Instituto Nacional de Investigaciones Forestales, Agrílas y Pecuarias) |
op_collection_id |
ftjpecurias |
language |
Spanish |
topic |
Rabies Wild animals Molecular variants Epidemiological cycle Spongiosis Bovine spongiform encephalopathy Rabia Fauna silvestre Variantes moleculares Ciclo epidemiológico Espongiosis Encefalopatía espongiforme bovina |
spellingShingle |
Rabies Wild animals Molecular variants Epidemiological cycle Spongiosis Bovine spongiform encephalopathy Rabia Fauna silvestre Variantes moleculares Ciclo epidemiológico Espongiosis Encefalopatía espongiforme bovina E.Weimersheimer, José Loza Rubio, Elizabeth Morales Salinas, Elizabeth Histopathological lesions in mice caused by rabies virus molecular variants circulating in Mexican wildlife |
topic_facet |
Rabies Wild animals Molecular variants Epidemiological cycle Spongiosis Bovine spongiform encephalopathy Rabia Fauna silvestre Variantes moleculares Ciclo epidemiológico Espongiosis Encefalopatía espongiforme bovina |
description |
The purpose of this study was to know weather some molecular variants of the rabies virus detected in Mexican wildlife could produce histopathological differences in mouse central nervous system. Five 6-mouse groups were inoculated intracerebrally with three different virus variants isolated from wildlife. Group 1) lynx/fox, Group 2) vampire bat, Group 3) skunk, Group 4) challenge virus standard (CVS), Group 5) normal mouse brain (NMB). Animals in Group 4 and those inoculated with all three different isolates resulted positive to the fluorescent antibody test. Animals in Group 1 had lesions characteristic of central nervous system (CNS), such as: inflammation, non-suppurative encephalitis, moderate-to-severe perivascular lymphocytic infiltration affecting only the hippocampus and the thalamic region, intra-cytoplasmic inclusions in the neurons (Negri's corpuscles), mild microgliosis, and spongiosis-like vacuoles of different sizes in the neuropil. Animals in Groups 2 and 3 showed similar lesions, but no spongiosis or Negri's corpuscles. None of the animals showed neuronophagia. No changes were found in Group 5. Differential diagnosis with bovine spongiform encephalopathy (BSE) is recommended, since very similar lesions were observed with the fox/lynx variant. El objetivo de este estudio fue conocer si algunas de las variantes moleculares del virus de la rabia detectadas en México producían diferencias histopatológicas en el sistema nervioso central de ratón. Se formaron cinco grupos con seis ratones cada uno, que se inocularon por vía intracerebral con tres variantes de fauna silvestre. Grupo 1) lince/zorro, Grupo 2) murciélago hematófago, Grupo 3) zorrillo, Grupo 4) virus estándar de desafío (CVS), Grupo 5) cerebro normal de ratón (CNR). El Grupo 4 y los animales inoculados con los tres diferentes aislamientos, resultaron positivos por anticuerpos fluorescentes. El Grupo 1 presentó lesiones características de inflamación en el sistema nerviosos central: encefalitis no supurativa, infiltrado linfocitario ... |
format |
Article in Journal/Newspaper |
author |
E.Weimersheimer, José Loza Rubio, Elizabeth Morales Salinas, Elizabeth |
author_facet |
E.Weimersheimer, José Loza Rubio, Elizabeth Morales Salinas, Elizabeth |
author_sort |
E.Weimersheimer, José |
title |
Histopathological lesions in mice caused by rabies virus molecular variants circulating in Mexican wildlife |
title_short |
Histopathological lesions in mice caused by rabies virus molecular variants circulating in Mexican wildlife |
title_full |
Histopathological lesions in mice caused by rabies virus molecular variants circulating in Mexican wildlife |
title_fullStr |
Histopathological lesions in mice caused by rabies virus molecular variants circulating in Mexican wildlife |
title_full_unstemmed |
Histopathological lesions in mice caused by rabies virus molecular variants circulating in Mexican wildlife |
title_sort |
histopathological lesions in mice caused by rabies virus molecular variants circulating in mexican wildlife |
publisher |
Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias |
publishDate |
2012 |
url |
https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/1401 |
genre |
Lince Lynx |
genre_facet |
Lince Lynx |
op_source |
Revista Mexicana de Ciencias Pecuarias; Vol. 42, Núm. 3 (2004); 411 a 417 2448-6698 2007-1124 |
op_relation |
https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/1401/1396 https://cienciaspecuarias.inifap.gob.mx/index.php/Pecuarias/article/view/1401 |
op_rights |
http://creativecommons.org/licenses/by-nc-sa/4.0 |
op_rightsnorm |
CC-BY-NC-SA |
_version_ |
1766243756937314304 |