Influenza aviaire H5N1 : problèmes posés par le vaccin chez l'animal et l'homme

An epizooty of H5N1 avian flu came out in South East Asia in 2003 and was reported in the beginning of the following year. It is progressing dangerously. As systematic bird slaughter has proved insufficient, inactivated vaccines are used. They are prepared from a H5N2 strain cultured in eggs, their...

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Bibliographic Details
Published in:Bulletin de l'Académie vétérinaire de France
Main Author: DURAND, Maurice Paul
Other Authors: Académie Vétérinaire de France, France, FRA
Format: Article in Journal/Newspaper
Language:French
Published: Académie vétérinaire de France, Paris (FRA) 2006
Subjects:
Grippe aviaire
Vétérinaire
Microbiologie
Vaccin
Homme
Avian influenza
Veterinary
Microbiology
Vaccine
Human
Slaughter
Avian flu
Online Access:http://hdl.handle.net/2042/47817
https://doi.org/10.4267/2042/47817
Description
Summary:An epizooty of H5N1 avian flu came out in South East Asia in 2003 and was reported in the beginning of the following year. It is progressing dangerously. As systematic bird slaughter has proved insufficient, inactivated vaccines are used. They are prepared from a H5N2 strain cultured in eggs, their efficacy is being questioned. Due to the virulence of H5N1, a human vaccine is currently being developed from a genetically reconstructed vaccine (using the A PR8 virus which has a low pathogenicity and the H1 and N1 of which have been replaced by H5 and N1 of the present epizootic viruses). Studies on other types of vaccines are currently under way. Une épizootie d'influenza aviaire H5N1 est apparue dans le Sud Est asiatique en 2003 et a été rapportée dès le début de l'année suivante. Elle se développe dangereusement. L'abattage systématique se révélant insuffisant, on a recours à des vaccins inactivés, préparés à partir d'une souche H5N2, cultivée sur oeuf embryonné, mais d'efficacité discutée. Le vaccin humain est préparé actuellement, en raison de la virulence du H5N1, à partir d'un virus reconstruit génétiquement (virus A PR8 peu pathogène dont on a substitué sa H1 et sa N1 par la H5 et la N1 des virus H5N1 épizootiques actuels). D'autres types de vaccins sont en cours d'étude.

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