MOLECULAR EPIDEMIOLOGY OF TUBERCULOSIS IN THE KALININGRAD REGION OF RUSSIA: 10 YEARS AFTER
In the Kaliningrad region, the incidence of tuberculosis (TB) has declined significantly over the past decade (from 134/100 000 in 2006 to 50.6/100 000 in 2015), but still exceeds the average for the North-West Russia (40.7/100 000). In view of the increase in the proportion of primary multidrug res...
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ftjiii:oai:iimmun.ru:article/594 2024-09-15T18:25:08+00:00 MOLECULAR EPIDEMIOLOGY OF TUBERCULOSIS IN THE KALININGRAD REGION OF RUSSIA: 10 YEARS AFTER МОЛЕКУЛЯРНАЯ ЭПИДЕМИОЛОГИЯ ТУБЕРКУЛЕЗА В КАЛИНИНГРАДСКОЙ ОБЛАСТИ РОССИИ: 10 ЛЕТ СПУСТЯ Vyazovaya A.A. Akhmedova G.M. Solovieva N.S. Gerasimova A.A. Starkova D.A. Turkin E.N. Zhuravlev V.Y. Narvskaya O.V. Mokrousov I.V. 2018-01-20 application/pdf https://iimmun.ru/iimm/article/view/594 https://doi.org/10.15789/2220-7619-2017-4-367-374 rus rus SPb RAACI https://iimmun.ru/iimm/article/view/594/350 https://iimmun.ru/iimm/article/view/594 doi:10.15789/2220-7619-2017-4-367-374 Copyright (c) 2018 Vyazovaya A.A., Akhmedova G.M., Solovieva N.S., Gerasimova A.A., Starkova D.A., Turkin E.N., Zhuravlev V.Y., Narvskaya O.V., Mokrousov I.V. https://creativecommons.org/licenses/by/4.0 Russian Journal of Infection and Immunity; Vol 7, No 4 (2017); 367-374 Инфекция и иммунитет; Vol 7, No 4 (2017); 367-374 2313-7398 2220-7619 10.15789/2220-7619-2017-4 pulmonary tuberculosis molecular epidemiology Kaliningrad region Mycobacterium tuberculosis drug resistance spoligotyping Beijing genotype туберкулез легких молекулярная эпидемиология Калининградская область лекарственная устойчивость сполиготипирование генотип Beijing info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2018 ftjiii https://doi.org/10.15789/2220-7619-2017-4-367-37410.15789/2220-7619-2017-4 2024-08-16T03:09:56Z In the Kaliningrad region, the incidence of tuberculosis (TB) has declined significantly over the past decade (from 134/100 000 in 2006 to 50.6/100 000 in 2015), but still exceeds the average for the North-West Russia (40.7/100 000). In view of the increase in the proportion of primary multidrug resistance (MDR) of the causative agent from 23.9% in 2010 to 30.5% in 2015, the aim of this study was to analyze the current Mycobacterium tuberculosis population structure in the Kaliningrad region and to evaluate its spatial-temporal trends. The 73 M. tuberculosis isolates from patients with pulmonary TB newly diagnosed in 2015 were studied. Drug resistance (DR) was detected in 46 (63.0%) M. tuberculosis strains; of these, 32 (43.8%) were multidrug-resistant (MDR). The 46 (63.0%) of 73 M. tuberculosis strains were of the Beijing genotype with 19.2% (14 out of 73) share of the B0/W148 cluster. Spoligotyping of 27 non-Beijing M. tuberculosis strains made it possible to identify 15 spoligotypes of 5 genetic families — T, LAM, Ural, S, X. About half (16; 51.6%) of non-Beijing strains were represented by spoligotypes — SIT42, SIT53, SIT262, and SIT444. In a heterogeneous group T, mostly drugsusceptible strains of spoligotype SIT53 were prevailing. More than half (55.6%) of the LAM genotype strains exhibited DR. The Ural family was small (5.5%) and included strains of well-known in Russia M. tuberculosis spoligotypes SIT35 and SIT262, and one new, not found previously. MDR was statistically significantly associated with the Beijing genotype: 56.5% versus 25.9% in strains of other genotypes (in total) (P = 0.0134). Moreover, all 14 strains of epidemiologically and clinically significant B0/W148 cluster were MDR. The proportion of MDR strains of the Beijing genotype did not change significantly: in 2006 it was 61.3%, in 2015 — 56.5% (P = 0.6773). However, the spectrum of drug resistance to first-line anti-TB drugs expanded. If previously the majority (78.9%) of MDR strains additionally exhibited resistance to streptomycin ... Article in Journal/Newspaper North-West Russia Russian Journal of Infection and Immunity (Infektsiya i immunitet) |
institution |
Open Polar |
collection |
Russian Journal of Infection and Immunity (Infektsiya i immunitet) |
op_collection_id |
ftjiii |
language |
Russian |
topic |
pulmonary tuberculosis molecular epidemiology Kaliningrad region Mycobacterium tuberculosis drug resistance spoligotyping Beijing genotype туберкулез легких молекулярная эпидемиология Калининградская область лекарственная устойчивость сполиготипирование генотип Beijing |
spellingShingle |
pulmonary tuberculosis molecular epidemiology Kaliningrad region Mycobacterium tuberculosis drug resistance spoligotyping Beijing genotype туберкулез легких молекулярная эпидемиология Калининградская область лекарственная устойчивость сполиготипирование генотип Beijing Vyazovaya A.A. Akhmedova G.M. Solovieva N.S. Gerasimova A.A. Starkova D.A. Turkin E.N. Zhuravlev V.Y. Narvskaya O.V. Mokrousov I.V. MOLECULAR EPIDEMIOLOGY OF TUBERCULOSIS IN THE KALININGRAD REGION OF RUSSIA: 10 YEARS AFTER |
topic_facet |
pulmonary tuberculosis molecular epidemiology Kaliningrad region Mycobacterium tuberculosis drug resistance spoligotyping Beijing genotype туберкулез легких молекулярная эпидемиология Калининградская область лекарственная устойчивость сполиготипирование генотип Beijing |
description |
In the Kaliningrad region, the incidence of tuberculosis (TB) has declined significantly over the past decade (from 134/100 000 in 2006 to 50.6/100 000 in 2015), but still exceeds the average for the North-West Russia (40.7/100 000). In view of the increase in the proportion of primary multidrug resistance (MDR) of the causative agent from 23.9% in 2010 to 30.5% in 2015, the aim of this study was to analyze the current Mycobacterium tuberculosis population structure in the Kaliningrad region and to evaluate its spatial-temporal trends. The 73 M. tuberculosis isolates from patients with pulmonary TB newly diagnosed in 2015 were studied. Drug resistance (DR) was detected in 46 (63.0%) M. tuberculosis strains; of these, 32 (43.8%) were multidrug-resistant (MDR). The 46 (63.0%) of 73 M. tuberculosis strains were of the Beijing genotype with 19.2% (14 out of 73) share of the B0/W148 cluster. Spoligotyping of 27 non-Beijing M. tuberculosis strains made it possible to identify 15 spoligotypes of 5 genetic families — T, LAM, Ural, S, X. About half (16; 51.6%) of non-Beijing strains were represented by spoligotypes — SIT42, SIT53, SIT262, and SIT444. In a heterogeneous group T, mostly drugsusceptible strains of spoligotype SIT53 were prevailing. More than half (55.6%) of the LAM genotype strains exhibited DR. The Ural family was small (5.5%) and included strains of well-known in Russia M. tuberculosis spoligotypes SIT35 and SIT262, and one new, not found previously. MDR was statistically significantly associated with the Beijing genotype: 56.5% versus 25.9% in strains of other genotypes (in total) (P = 0.0134). Moreover, all 14 strains of epidemiologically and clinically significant B0/W148 cluster were MDR. The proportion of MDR strains of the Beijing genotype did not change significantly: in 2006 it was 61.3%, in 2015 — 56.5% (P = 0.6773). However, the spectrum of drug resistance to first-line anti-TB drugs expanded. If previously the majority (78.9%) of MDR strains additionally exhibited resistance to streptomycin ... |
format |
Article in Journal/Newspaper |
author |
Vyazovaya A.A. Akhmedova G.M. Solovieva N.S. Gerasimova A.A. Starkova D.A. Turkin E.N. Zhuravlev V.Y. Narvskaya O.V. Mokrousov I.V. |
author_facet |
Vyazovaya A.A. Akhmedova G.M. Solovieva N.S. Gerasimova A.A. Starkova D.A. Turkin E.N. Zhuravlev V.Y. Narvskaya O.V. Mokrousov I.V. |
author_sort |
Vyazovaya A.A. |
title |
MOLECULAR EPIDEMIOLOGY OF TUBERCULOSIS IN THE KALININGRAD REGION OF RUSSIA: 10 YEARS AFTER |
title_short |
MOLECULAR EPIDEMIOLOGY OF TUBERCULOSIS IN THE KALININGRAD REGION OF RUSSIA: 10 YEARS AFTER |
title_full |
MOLECULAR EPIDEMIOLOGY OF TUBERCULOSIS IN THE KALININGRAD REGION OF RUSSIA: 10 YEARS AFTER |
title_fullStr |
MOLECULAR EPIDEMIOLOGY OF TUBERCULOSIS IN THE KALININGRAD REGION OF RUSSIA: 10 YEARS AFTER |
title_full_unstemmed |
MOLECULAR EPIDEMIOLOGY OF TUBERCULOSIS IN THE KALININGRAD REGION OF RUSSIA: 10 YEARS AFTER |
title_sort |
molecular epidemiology of tuberculosis in the kaliningrad region of russia: 10 years after |
publisher |
SPb RAACI |
publishDate |
2018 |
url |
https://iimmun.ru/iimm/article/view/594 https://doi.org/10.15789/2220-7619-2017-4-367-374 |
genre |
North-West Russia |
genre_facet |
North-West Russia |
op_source |
Russian Journal of Infection and Immunity; Vol 7, No 4 (2017); 367-374 Инфекция и иммунитет; Vol 7, No 4 (2017); 367-374 2313-7398 2220-7619 10.15789/2220-7619-2017-4 |
op_relation |
https://iimmun.ru/iimm/article/view/594/350 https://iimmun.ru/iimm/article/view/594 doi:10.15789/2220-7619-2017-4-367-374 |
op_rights |
Copyright (c) 2018 Vyazovaya A.A., Akhmedova G.M., Solovieva N.S., Gerasimova A.A., Starkova D.A., Turkin E.N., Zhuravlev V.Y., Narvskaya O.V., Mokrousov I.V. https://creativecommons.org/licenses/by/4.0 |
op_doi |
https://doi.org/10.15789/2220-7619-2017-4-367-37410.15789/2220-7619-2017-4 |
_version_ |
1810465557148860416 |