Results of implementation of viral hepatitis B elimination program in the North-West Russia
Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the distri...
Published in: | Russian Journal of Infection and Immunity |
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Format: | Article in Journal/Newspaper |
Language: | Russian |
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SPb RAACI
2021
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Online Access: | https://iimmun.ru/iimm/article/view/1785 https://doi.org/10.15789/2220-7619-ROT-1785 |
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ftjiii:oai:iimmun.ru:article/1785 |
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Russian Journal of Infection and Immunity (Infektsiya i immunitet) |
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ftjiii |
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Russian |
topic |
hepatitis B virus morbidity genotypes vaccination elimination вирусный гепатит В заболеваемость генотипы вакцинация элиминация |
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hepatitis B virus morbidity genotypes vaccination elimination вирусный гепатит В заболеваемость генотипы вакцинация элиминация Lyalina L.V. Esaulenko E.V. Khorkova E.V. Novak K.E. Ostankova Y.V. Serikova E.N. Vasilyev D.V. Gorziy E.S. Butskaya M.J. Kritskaya I.V. Buts L.V. Grebenkina E.V. Baydakova E.V. Smirnova N.A. Krasnopyorova M.A. Koltsov N.S. Kotovich L.M. Kalinina E.L. Galimov R.R. Kirkhar N.V. Cherepanova E.A. Totolian A.A. Results of implementation of viral hepatitis B elimination program in the North-West Russia |
topic_facet |
hepatitis B virus morbidity genotypes vaccination elimination вирусный гепатит В заболеваемость генотипы вакцинация элиминация |
description |
Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in ... |
format |
Article in Journal/Newspaper |
author |
Lyalina L.V. Esaulenko E.V. Khorkova E.V. Novak K.E. Ostankova Y.V. Serikova E.N. Vasilyev D.V. Gorziy E.S. Butskaya M.J. Kritskaya I.V. Buts L.V. Grebenkina E.V. Baydakova E.V. Smirnova N.A. Krasnopyorova M.A. Koltsov N.S. Kotovich L.M. Kalinina E.L. Galimov R.R. Kirkhar N.V. Cherepanova E.A. Totolian A.A. |
author_facet |
Lyalina L.V. Esaulenko E.V. Khorkova E.V. Novak K.E. Ostankova Y.V. Serikova E.N. Vasilyev D.V. Gorziy E.S. Butskaya M.J. Kritskaya I.V. Buts L.V. Grebenkina E.V. Baydakova E.V. Smirnova N.A. Krasnopyorova M.A. Koltsov N.S. Kotovich L.M. Kalinina E.L. Galimov R.R. Kirkhar N.V. Cherepanova E.A. Totolian A.A. |
author_sort |
Lyalina L.V. |
title |
Results of implementation of viral hepatitis B elimination program in the North-West Russia |
title_short |
Results of implementation of viral hepatitis B elimination program in the North-West Russia |
title_full |
Results of implementation of viral hepatitis B elimination program in the North-West Russia |
title_fullStr |
Results of implementation of viral hepatitis B elimination program in the North-West Russia |
title_full_unstemmed |
Results of implementation of viral hepatitis B elimination program in the North-West Russia |
title_sort |
results of implementation of viral hepatitis b elimination program in the north-west russia |
publisher |
SPb RAACI |
publishDate |
2021 |
url |
https://iimmun.ru/iimm/article/view/1785 https://doi.org/10.15789/2220-7619-ROT-1785 |
genre |
North-West Russia |
genre_facet |
North-West Russia |
op_source |
Russian Journal of Infection and Immunity; Vol 11, No 5 (2021); 875-886 Инфекция и иммунитет; Vol 11, No 5 (2021); 875-886 2313-7398 2220-7619 |
op_relation |
https://iimmun.ru/iimm/article/view/1785/1328 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6986 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6987 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6988 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6989 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6990 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6991 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6992 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6993 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6994 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6995 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6996 https://iimmun.ru/iimm/article/downloadSuppFile/1785/7055 https://iimmun.ru/iimm/article/view/1785 doi:10.15789/2220-7619-ROT-1785 |
op_rights |
Copyright (c) 2021 Lyalina L.V., Esaulenko E.V., Khorkova E.V., Novak K.E., Ostankova Y.V., Serikova E.N., Vasilyev D.V., Gorziy E.S., Butskaya M.J., Kritskaya I.V., Buts L.V., Grebenkina E.V., Baydakova E.V., Smirnova N.A., Krasnopyorova M.A., Koltsov N.S., Kotovich L.M., Kalinina E.L., Galimov R.R., Kirkhar N.V., Cherepanova E.A., Totolian A.A. https://creativecommons.org/licenses/by/4.0 |
op_doi |
https://doi.org/10.15789/2220-7619-ROT-1785 |
container_title |
Russian Journal of Infection and Immunity |
container_volume |
11 |
container_issue |
5 |
container_start_page |
875 |
op_container_end_page |
886 |
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1775353615397945344 |
spelling |
ftjiii:oai:iimmun.ru:article/1785 2023-08-27T04:11:07+02:00 Results of implementation of viral hepatitis B elimination program in the North-West Russia Результаты реализации программы элиминации вирусного гепатита В на CевероЗападе России Lyalina L.V. Esaulenko E.V. Khorkova E.V. Novak K.E. Ostankova Y.V. Serikova E.N. Vasilyev D.V. Gorziy E.S. Butskaya M.J. Kritskaya I.V. Buts L.V. Grebenkina E.V. Baydakova E.V. Smirnova N.A. Krasnopyorova M.A. Koltsov N.S. Kotovich L.M. Kalinina E.L. Galimov R.R. Kirkhar N.V. Cherepanova E.A. Totolian A.A. 2021-09-01 application/pdf https://iimmun.ru/iimm/article/view/1785 https://doi.org/10.15789/2220-7619-ROT-1785 rus rus SPb RAACI https://iimmun.ru/iimm/article/view/1785/1328 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6986 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6987 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6988 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6989 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6990 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6991 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6992 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6993 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6994 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6995 https://iimmun.ru/iimm/article/downloadSuppFile/1785/6996 https://iimmun.ru/iimm/article/downloadSuppFile/1785/7055 https://iimmun.ru/iimm/article/view/1785 doi:10.15789/2220-7619-ROT-1785 Copyright (c) 2021 Lyalina L.V., Esaulenko E.V., Khorkova E.V., Novak K.E., Ostankova Y.V., Serikova E.N., Vasilyev D.V., Gorziy E.S., Butskaya M.J., Kritskaya I.V., Buts L.V., Grebenkina E.V., Baydakova E.V., Smirnova N.A., Krasnopyorova M.A., Koltsov N.S., Kotovich L.M., Kalinina E.L., Galimov R.R., Kirkhar N.V., Cherepanova E.A., Totolian A.A. https://creativecommons.org/licenses/by/4.0 Russian Journal of Infection and Immunity; Vol 11, No 5 (2021); 875-886 Инфекция и иммунитет; Vol 11, No 5 (2021); 875-886 2313-7398 2220-7619 hepatitis B virus morbidity genotypes vaccination elimination вирусный гепатит В заболеваемость генотипы вакцинация элиминация info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2021 ftjiii https://doi.org/10.15789/2220-7619-ROT-1785 2023-08-08T20:22:46Z Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in ... Article in Journal/Newspaper North-West Russia Russian Journal of Infection and Immunity (Infektsiya i immunitet) Russian Journal of Infection and Immunity 11 5 875 886 |