Helpful or Harmful? A Case Report of Nutritional Supplements Causing Drug-Induced Liver Injury
Herbal supplement-induced liver injury represents a growing concern in the body of drug-induced liver injury (DILI) literature, with recent studies in mainland China, Iceland, and the United States reporting estimated rates of herb/dietary supplement-induced liver injury (HILI) between 1.16-6.38 per...
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2023
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ftjeffersonuniv:oai:jdc.jefferson.edu:tmf-1523 2023-08-20T04:07:30+02:00 Helpful or Harmful? A Case Report of Nutritional Supplements Causing Drug-Induced Liver Injury Bhasin, MD, Amman Chun, MD, Phoebe Bilello, MD, Justin Ambelil, MD, Manju Halegoua-DeMarzio, MD, Dina L. 2023-07-25T20:46:37Z application/pdf https://jdc.jefferson.edu/tmf/vol24/iss1/11 https://doi.org/10.29046/TMF.024.1.010 https://jdc.jefferson.edu/context/tmf/article/1523/viewcontent/202307_Medicine_Forum_Helpful_or_Harmful.pdf unknown Jefferson Digital Commons https://jdc.jefferson.edu/tmf/vol24/iss1/11 doi:10.29046/TMF.024.1.010 https://jdc.jefferson.edu/context/tmf/article/1523/viewcontent/202307_Medicine_Forum_Helpful_or_Harmful.pdf The Medicine Forum Internal Medicine Medicine and Health Sciences casereport 2023 ftjeffersonuniv https://doi.org/10.29046/TMF.024.1.010 2023-07-30T16:30:14Z Herbal supplement-induced liver injury represents a growing concern in the body of drug-induced liver injury (DILI) literature, with recent studies in mainland China, Iceland, and the United States reporting estimated rates of herb/dietary supplement-induced liver injury (HILI) between 1.16-6.38 per 100,000 (Björnsson et al., 2013; Shen et al., 2019; Vega et al., 2017). Notably, a recent 2020 study demonstrated an increasing prevalence of hepatotoxicity secondary to herbal and dietary supplements in the US and worldwide (Zheng et al., 2020). Recognizing the hepatotoxicity of various supplements is crucial, given the increasing usage of dietary and herbal supplements and the lack of regulation of herbal supplements in the United States. HRP-AID is marketed as a twice-daily "immune system booster" to reduce the intensity and frequency of cold sore outbreaks. The product ingredients include 200 mg ascorbic acid, 20 mcg cholecalciferol, 20 mg a-tocopherol, 10 mg pyridoxine HCl, 50 mcg methylcobalamin, 25 mg zinc citrate, 70 mcg selenium, 250 mg L-lysine, 50 mg Astralagus extract (Astragalus membranaceus), 50 mg Echinacea (Echinacea purpurea), 50 mg garlic powder (Allium salivum), 50 mg natural caffeine (coffee arabica), 50 mg olive leaf extract Oleuropin 20% (Olea Europaea), 50 mg oregano powder (Thymus captatus), 50 mg of elderberry extract (Sambucus nigra) and 50 mg Red Panax ginseng extract (Panax ginseng). A literature review demonstrates that this is the first reported case of DILI secondary to HRP-AID supplementation. Report Iceland Jefferson Digital Commons (Thomas Jefferson University, Philadelphia) The Medicine Forum 24 1 |
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Jefferson Digital Commons (Thomas Jefferson University, Philadelphia) |
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Internal Medicine Medicine and Health Sciences |
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Internal Medicine Medicine and Health Sciences Bhasin, MD, Amman Chun, MD, Phoebe Bilello, MD, Justin Ambelil, MD, Manju Halegoua-DeMarzio, MD, Dina L. Helpful or Harmful? A Case Report of Nutritional Supplements Causing Drug-Induced Liver Injury |
topic_facet |
Internal Medicine Medicine and Health Sciences |
description |
Herbal supplement-induced liver injury represents a growing concern in the body of drug-induced liver injury (DILI) literature, with recent studies in mainland China, Iceland, and the United States reporting estimated rates of herb/dietary supplement-induced liver injury (HILI) between 1.16-6.38 per 100,000 (Björnsson et al., 2013; Shen et al., 2019; Vega et al., 2017). Notably, a recent 2020 study demonstrated an increasing prevalence of hepatotoxicity secondary to herbal and dietary supplements in the US and worldwide (Zheng et al., 2020). Recognizing the hepatotoxicity of various supplements is crucial, given the increasing usage of dietary and herbal supplements and the lack of regulation of herbal supplements in the United States. HRP-AID is marketed as a twice-daily "immune system booster" to reduce the intensity and frequency of cold sore outbreaks. The product ingredients include 200 mg ascorbic acid, 20 mcg cholecalciferol, 20 mg a-tocopherol, 10 mg pyridoxine HCl, 50 mcg methylcobalamin, 25 mg zinc citrate, 70 mcg selenium, 250 mg L-lysine, 50 mg Astralagus extract (Astragalus membranaceus), 50 mg Echinacea (Echinacea purpurea), 50 mg garlic powder (Allium salivum), 50 mg natural caffeine (coffee arabica), 50 mg olive leaf extract Oleuropin 20% (Olea Europaea), 50 mg oregano powder (Thymus captatus), 50 mg of elderberry extract (Sambucus nigra) and 50 mg Red Panax ginseng extract (Panax ginseng). A literature review demonstrates that this is the first reported case of DILI secondary to HRP-AID supplementation. |
format |
Report |
author |
Bhasin, MD, Amman Chun, MD, Phoebe Bilello, MD, Justin Ambelil, MD, Manju Halegoua-DeMarzio, MD, Dina L. |
author_facet |
Bhasin, MD, Amman Chun, MD, Phoebe Bilello, MD, Justin Ambelil, MD, Manju Halegoua-DeMarzio, MD, Dina L. |
author_sort |
Bhasin, MD, Amman |
title |
Helpful or Harmful? A Case Report of Nutritional Supplements Causing Drug-Induced Liver Injury |
title_short |
Helpful or Harmful? A Case Report of Nutritional Supplements Causing Drug-Induced Liver Injury |
title_full |
Helpful or Harmful? A Case Report of Nutritional Supplements Causing Drug-Induced Liver Injury |
title_fullStr |
Helpful or Harmful? A Case Report of Nutritional Supplements Causing Drug-Induced Liver Injury |
title_full_unstemmed |
Helpful or Harmful? A Case Report of Nutritional Supplements Causing Drug-Induced Liver Injury |
title_sort |
helpful or harmful? a case report of nutritional supplements causing drug-induced liver injury |
publisher |
Jefferson Digital Commons |
publishDate |
2023 |
url |
https://jdc.jefferson.edu/tmf/vol24/iss1/11 https://doi.org/10.29046/TMF.024.1.010 https://jdc.jefferson.edu/context/tmf/article/1523/viewcontent/202307_Medicine_Forum_Helpful_or_Harmful.pdf |
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Iceland |
genre_facet |
Iceland |
op_source |
The Medicine Forum |
op_relation |
https://jdc.jefferson.edu/tmf/vol24/iss1/11 doi:10.29046/TMF.024.1.010 https://jdc.jefferson.edu/context/tmf/article/1523/viewcontent/202307_Medicine_Forum_Helpful_or_Harmful.pdf |
op_doi |
https://doi.org/10.29046/TMF.024.1.010 |
container_title |
The Medicine Forum |
container_volume |
24 |
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1 |
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