Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis
The aim. The objective of the research was to study the pharmacological activity of dry extract of Sakhalin willow shoots – DEWS against the background of experimental thrombophlebitis. Materials and methods. Dry extract of Sakhalin willow shoots (DEWS) was the object matter of the present research...
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РС ТЕСHNOLOGY СЕNTЕR
2023
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ftjeepe:oai:ojs.journals.uran.ua:article/286723 2023-10-01T03:59:12+02:00 Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis Вивчення фармакологічної активності сухого екстракту пагонів верби сахалінської на тлі експериментального тромбофлебіту Бородіна, Наталія Валеріївна Малоштан, Людмила Миколаївна Артемова, Катерина Олегівна Кухтенко, Олександр Сергійович 2023-08-31 application/pdf https://journals.uran.ua/sr_pharm/article/view/286723 eng eng РС ТЕСHNOLOGY СЕNTЕR https://journals.uran.ua/sr_pharm/article/view/286723/280663 https://journals.uran.ua/sr_pharm/article/view/286723 Авторське право (c) 2023 Natalia Borodina, Liudmyla Maloshtan, Kateryna Artemova, Oleksandr Kukhtenko http://creativecommons.org/licenses/by/4.0 ScienceRise: Pharmaceutical Science; No. 4(44) (2023); 97-103 ScienceRise: Pharmaceutical Science; № 4(44) (2023); 97-103 2519-4852 2519-4844 dry extract of Sakhalin willow shoots experimental thrombophlebitis inflammatory process pharmacological activity rabbits сухий екстракт пагонів верби сахалінської експериментальний тромбофлебіт запальний процес фармакологічна активність кролі info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2023 ftjeepe 2023-09-05T01:00:08Z The aim. The objective of the research was to study the pharmacological activity of dry extract of Sakhalin willow shoots – DEWS against the background of experimental thrombophlebitis. Materials and methods. Dry extract of Sakhalin willow shoots (DEWS) was the object matter of the present research and served as a therapeutic and prophylactic agent. In the experiment conducted, rabbits weighing 2.0 – 2.5 kg were used. The animals were divided into three groups. Group 1 was a control group; group 2 were animals that had been intragastrically injected with DEWS at a dose of 30 mg/kg prior to modelling thrombophlebitis; group 3 similarly received Eskuvit 20 mg/kg as a reference drug – pills (JSC Halychpharm, Ukraine). The dose for animals was recalculated, taking into account body weight according to the Rybolovlev method. Experimental thrombophlebitis was caused by injecting an intravenous solution of 2 % lugol at a dose of 0.1 ml into the marginal vein of the ear. Statistical data processing was carried out using the Statistica for Windows 11.0 program based on variance analysis for repeated measurement data using the Mann-Whitney criteria at a probability level of p<0.05. Results. Against the background of the development of experimental thrombophlebitis in rabbits, the development of thrombosis of the ear vein and the inflammatory process of adjacent tissues were observed. The inflammatory process was accompanied by pronounced hyperemia and oedema. Prophylactic administration of DEWS for 6 days contributed to a decrease in the inflammatory process already on the 5th day of observation. The area of the injured area was 20 % smaller than in the control pathology group. The therapeutic and prophylactic effect of herbal medicine can be explained by the content of flavonoids and salicylates in its composition. Eskuvit showed a less pronounced thrombolytic effect in terms of its influence on thrombosis and thrombolysis. Conclusions. The administration of DEWS in the therapeutic and prophylactic regimen at a dose ... Article in Journal/Newspaper Sakhalin Electrical Engineering and Power Engineering (EE&PE - E-Journal) |
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Open Polar |
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Electrical Engineering and Power Engineering (EE&PE - E-Journal) |
op_collection_id |
ftjeepe |
language |
English |
topic |
dry extract of Sakhalin willow shoots experimental thrombophlebitis inflammatory process pharmacological activity rabbits сухий екстракт пагонів верби сахалінської експериментальний тромбофлебіт запальний процес фармакологічна активність кролі |
spellingShingle |
dry extract of Sakhalin willow shoots experimental thrombophlebitis inflammatory process pharmacological activity rabbits сухий екстракт пагонів верби сахалінської експериментальний тромбофлебіт запальний процес фармакологічна активність кролі Бородіна, Наталія Валеріївна Малоштан, Людмила Миколаївна Артемова, Катерина Олегівна Кухтенко, Олександр Сергійович Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
topic_facet |
dry extract of Sakhalin willow shoots experimental thrombophlebitis inflammatory process pharmacological activity rabbits сухий екстракт пагонів верби сахалінської експериментальний тромбофлебіт запальний процес фармакологічна активність кролі |
description |
The aim. The objective of the research was to study the pharmacological activity of dry extract of Sakhalin willow shoots – DEWS against the background of experimental thrombophlebitis. Materials and methods. Dry extract of Sakhalin willow shoots (DEWS) was the object matter of the present research and served as a therapeutic and prophylactic agent. In the experiment conducted, rabbits weighing 2.0 – 2.5 kg were used. The animals were divided into three groups. Group 1 was a control group; group 2 were animals that had been intragastrically injected with DEWS at a dose of 30 mg/kg prior to modelling thrombophlebitis; group 3 similarly received Eskuvit 20 mg/kg as a reference drug – pills (JSC Halychpharm, Ukraine). The dose for animals was recalculated, taking into account body weight according to the Rybolovlev method. Experimental thrombophlebitis was caused by injecting an intravenous solution of 2 % lugol at a dose of 0.1 ml into the marginal vein of the ear. Statistical data processing was carried out using the Statistica for Windows 11.0 program based on variance analysis for repeated measurement data using the Mann-Whitney criteria at a probability level of p<0.05. Results. Against the background of the development of experimental thrombophlebitis in rabbits, the development of thrombosis of the ear vein and the inflammatory process of adjacent tissues were observed. The inflammatory process was accompanied by pronounced hyperemia and oedema. Prophylactic administration of DEWS for 6 days contributed to a decrease in the inflammatory process already on the 5th day of observation. The area of the injured area was 20 % smaller than in the control pathology group. The therapeutic and prophylactic effect of herbal medicine can be explained by the content of flavonoids and salicylates in its composition. Eskuvit showed a less pronounced thrombolytic effect in terms of its influence on thrombosis and thrombolysis. Conclusions. The administration of DEWS in the therapeutic and prophylactic regimen at a dose ... |
format |
Article in Journal/Newspaper |
author |
Бородіна, Наталія Валеріївна Малоштан, Людмила Миколаївна Артемова, Катерина Олегівна Кухтенко, Олександр Сергійович |
author_facet |
Бородіна, Наталія Валеріївна Малоштан, Людмила Миколаївна Артемова, Катерина Олегівна Кухтенко, Олександр Сергійович |
author_sort |
Бородіна, Наталія Валеріївна |
title |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_short |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_full |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_fullStr |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_full_unstemmed |
Study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
title_sort |
study of pharmacological activity of dry extract of sakhalin willow shoots against the background of experimental thrombophlebitis |
publisher |
РС ТЕСHNOLOGY СЕNTЕR |
publishDate |
2023 |
url |
https://journals.uran.ua/sr_pharm/article/view/286723 |
genre |
Sakhalin |
genre_facet |
Sakhalin |
op_source |
ScienceRise: Pharmaceutical Science; No. 4(44) (2023); 97-103 ScienceRise: Pharmaceutical Science; № 4(44) (2023); 97-103 2519-4852 2519-4844 |
op_relation |
https://journals.uran.ua/sr_pharm/article/view/286723/280663 https://journals.uran.ua/sr_pharm/article/view/286723 |
op_rights |
Авторське право (c) 2023 Natalia Borodina, Liudmyla Maloshtan, Kateryna Artemova, Oleksandr Kukhtenko http://creativecommons.org/licenses/by/4.0 |
_version_ |
1778532862053580800 |