Impact of dietary glutathione on hematological indices in rats poisoned with hexavalent chromium

• Published in: Journal of Applied and Natural Science
• Main Authors: Kumar, Ajay, Kumar, Alok
• Format: Article in Journal/Newspaper
• Language: English
• Published: Applied and Natural Science Foundation 2013
• Subjects: Glutathione; Chromium; Blood; Enzymes; Rat; Rattus rattus
• Online Access: https://journals.ansfoundation.org/index.php/jans/article/view/309; https://doi.org/10.31018/jans.v5i1.309

The effects of dietary glutathione against chromium induced hematological indices were studied in rats, Rattus rattus albino. Supplementation of glutahione to the diet of chromium fed rats, elevated significantly percent hemoglobin (40.4%), number of red blood corpuscles (48.7%), plasma corpuscular volume (43.4%) and mean corpuscular volume (37.1%) which were inhibited in chromium poisoned rats. However, no marked elevation was noticed in number of white blood corpuscles and total proteins. Intake of glutahione checked the accumulation of glucose, cholesterol, tryglcerides, phospholipids and bilirubin in chromium treated rats. Chromium intoxication significantly increased the activities of transaminases (p<0.001) and dehydrogenases (p<0.01/p<0.001) which declined by supplementation of gltathione which also restored the chromium inhibited activity of alkaline and acid phosphatase. Specific reasons for these pharmacoticological aspects of glutathione have also been discussed.