Antioxidative role of selected herbs against ethanol induced liver injury in rats
The purpose of this study was to know the hepatotoxicity of ethanol in laboratory rats Rattus rattus and to observe the individual and combined phytotherapeutic role of five herbs viz. Arctium lappa, Curcuma longa, Piper longum, Plumbago zeylanica and Terminalia chebula through biochemical and histo...
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ftjans:oai:journals.ansfoundation.org:article/187 2023-05-15T18:05:24+02:00 Antioxidative role of selected herbs against ethanol induced liver injury in rats Kumar, Sunil Kumari, Priyanka Devi, Shoma 2011-12-01 application/pdf https://journals.ansfoundation.org/index.php/jans/article/view/187 https://doi.org/10.31018/jans.v3i2.187 eng eng Applied and Natural Science Foundation https://journals.ansfoundation.org/index.php/jans/article/view/187/167 https://journals.ansfoundation.org/index.php/jans/article/view/187 doi:10.31018/jans.v3i2.187 Journal of Applied and Natural Science; Vol. 3 No. 2 (2011); 242-246 2231-5209 0974-9411 Hepatotoxicity Histopathology Ethanol Herbal Combination Antioxidant info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2011 ftjans https://doi.org/10.31018/jans.v3i2.187 2022-12-30T10:53:55Z The purpose of this study was to know the hepatotoxicity of ethanol in laboratory rats Rattus rattus and to observe the individual and combined phytotherapeutic role of five herbs viz. Arctium lappa, Curcuma longa, Piper longum, Plumbago zeylanica and Terminalia chebula through biochemical and histopathological parameters. Ethanol is commonly used as solvent, pharmaceutical, drugs and alcohol abuse. Lipidperoxidation, glutathione content, urinary hydroxyproline, collagen and histopathological studies showed hepatotoxicity of 1 ml/kg bodyweight dose of ethanol and protective role of 100 mg/kg body weight dose of herbs. Histopathological changes observed in the liver of rats after ethanol treatment showed hepatitis, collagenesis, fatty infiltration, sclerosis, perilobular necrosis, cytoplasmic degeneration, enlarged bile canaliculi, hydropic degeneration, focal necrosis, binucleated hepatocytes and nuclear degeneration. Mild cytoplasmic degeneration, necrosis, collagenesis and hepatocytes regenerations were observed in rats treated with same dose of ethanol and herbal combination.Ethanol treatment decreased the glutathione content, increased tissue malondialdehyde and collagen content, thus causing tissue injury and liver collagenesis. Urinary hydroxyproline level and biochemical parameters also showed the protective role of herbs against ethanol induced toxicity. Herbal combination i. e. 100ml/kg body weight from the mixture of five herbs given orally was found more effective than their individual role. Herbs and plants contain aromatic substances, secondary metabolites, alkaloids and polyphenols which act as antioxidant thus showing protective role. Article in Journal/Newspaper Rattus rattus Journal of Applied and Natural Science Journal of Applied and Natural Science 3 2 242 246 |
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Open Polar |
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Journal of Applied and Natural Science |
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English |
topic |
Hepatotoxicity Histopathology Ethanol Herbal Combination Antioxidant |
spellingShingle |
Hepatotoxicity Histopathology Ethanol Herbal Combination Antioxidant Kumar, Sunil Kumari, Priyanka Devi, Shoma Antioxidative role of selected herbs against ethanol induced liver injury in rats |
topic_facet |
Hepatotoxicity Histopathology Ethanol Herbal Combination Antioxidant |
description |
The purpose of this study was to know the hepatotoxicity of ethanol in laboratory rats Rattus rattus and to observe the individual and combined phytotherapeutic role of five herbs viz. Arctium lappa, Curcuma longa, Piper longum, Plumbago zeylanica and Terminalia chebula through biochemical and histopathological parameters. Ethanol is commonly used as solvent, pharmaceutical, drugs and alcohol abuse. Lipidperoxidation, glutathione content, urinary hydroxyproline, collagen and histopathological studies showed hepatotoxicity of 1 ml/kg bodyweight dose of ethanol and protective role of 100 mg/kg body weight dose of herbs. Histopathological changes observed in the liver of rats after ethanol treatment showed hepatitis, collagenesis, fatty infiltration, sclerosis, perilobular necrosis, cytoplasmic degeneration, enlarged bile canaliculi, hydropic degeneration, focal necrosis, binucleated hepatocytes and nuclear degeneration. Mild cytoplasmic degeneration, necrosis, collagenesis and hepatocytes regenerations were observed in rats treated with same dose of ethanol and herbal combination.Ethanol treatment decreased the glutathione content, increased tissue malondialdehyde and collagen content, thus causing tissue injury and liver collagenesis. Urinary hydroxyproline level and biochemical parameters also showed the protective role of herbs against ethanol induced toxicity. Herbal combination i. e. 100ml/kg body weight from the mixture of five herbs given orally was found more effective than their individual role. Herbs and plants contain aromatic substances, secondary metabolites, alkaloids and polyphenols which act as antioxidant thus showing protective role. |
format |
Article in Journal/Newspaper |
author |
Kumar, Sunil Kumari, Priyanka Devi, Shoma |
author_facet |
Kumar, Sunil Kumari, Priyanka Devi, Shoma |
author_sort |
Kumar, Sunil |
title |
Antioxidative role of selected herbs against ethanol induced liver injury in rats |
title_short |
Antioxidative role of selected herbs against ethanol induced liver injury in rats |
title_full |
Antioxidative role of selected herbs against ethanol induced liver injury in rats |
title_fullStr |
Antioxidative role of selected herbs against ethanol induced liver injury in rats |
title_full_unstemmed |
Antioxidative role of selected herbs against ethanol induced liver injury in rats |
title_sort |
antioxidative role of selected herbs against ethanol induced liver injury in rats |
publisher |
Applied and Natural Science Foundation |
publishDate |
2011 |
url |
https://journals.ansfoundation.org/index.php/jans/article/view/187 https://doi.org/10.31018/jans.v3i2.187 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Journal of Applied and Natural Science; Vol. 3 No. 2 (2011); 242-246 2231-5209 0974-9411 |
op_relation |
https://journals.ansfoundation.org/index.php/jans/article/view/187/167 https://journals.ansfoundation.org/index.php/jans/article/view/187 doi:10.31018/jans.v3i2.187 |
op_doi |
https://doi.org/10.31018/jans.v3i2.187 |
container_title |
Journal of Applied and Natural Science |
container_volume |
3 |
container_issue |
2 |
container_start_page |
242 |
op_container_end_page |
246 |
_version_ |
1766176879891447808 |