Investigation into the effects of oral contraceptives on some haematological parameters of Wistar albino rat Rattus rattus
In this study, the in vivo effect of oral contraceptives namely Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) and Primolut -N a mini pill (5mg norethisterone) onsome haematological parameters of wistar albino rat were investigated. The haemoglobin count, packed cell...
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Faculty of Science, University of Port Harcourt Port Harcourt
2017
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ftjafricanj:oai:ojs.ajol.info:article/156522 2023-05-15T18:05:20+02:00 Investigation into the effects of oral contraceptives on some haematological parameters of Wistar albino rat Rattus rattus Okoye, N.F. Uwakwe, A.A. 2017-05-25 application/pdf https://www.ajol.info/index.php/sa/article/view/156522 eng eng Faculty of Science, University of Port Harcourt Port Harcourt https://www.ajol.info/index.php/sa/article/view/156522/146132 https://www.ajol.info/index.php/sa/article/view/156522 Copyright is owned by the journal Scientia Africana; Vol 15, No 2 (2016) 1118-1931 Blood ethinylestradiol haematological parameters lenonorgestrel norethisterone oral contraceptives info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article 2017 ftjafricanj 2017-05-27T23:57:50Z In this study, the in vivo effect of oral contraceptives namely Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) and Primolut -N a mini pill (5mg norethisterone) onsome haematological parameters of wistar albino rat were investigated. The haemoglobin count, packed cell volume, total white blood cell count, platelet count, neutrophil and lymphocyte count were assayed. Test results showed that the oral contraceptives had an increasingeffect on the haematological parameters. This increase was not dose dependent. The highest increase of 18.00 ± 1.40 vs control 14.30 ± 1.10 (g/dl) was obtained for Hb at the concentration of 0.72μg at 2 hours duration (p< 0.05).The blood PCV, WBC, platelet, neutrophil and lymphocyte analysis also showed increases. The possible implications of these findings on the female rat and by extrapolation on the female ‘homo sapiens’ are that laboratory tests involving full blood analysis should be undergone before these drugs are taken. Check-up tests should also be performed every six months, to identify women who might be at risk of developing minor or serious side effects that might affect major organs of the body.Keywords: Blood, ethinylestradiol, haematological parameters, lenonorgestrel, norethisterone, oral contraceptives Article in Journal/Newspaper Rattus rattus AJOL - African Journals Online |
institution |
Open Polar |
collection |
AJOL - African Journals Online |
op_collection_id |
ftjafricanj |
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English |
topic |
Blood ethinylestradiol haematological parameters lenonorgestrel norethisterone oral contraceptives |
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Blood ethinylestradiol haematological parameters lenonorgestrel norethisterone oral contraceptives Okoye, N.F. Uwakwe, A.A. Investigation into the effects of oral contraceptives on some haematological parameters of Wistar albino rat Rattus rattus |
topic_facet |
Blood ethinylestradiol haematological parameters lenonorgestrel norethisterone oral contraceptives |
description |
In this study, the in vivo effect of oral contraceptives namely Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) and Primolut -N a mini pill (5mg norethisterone) onsome haematological parameters of wistar albino rat were investigated. The haemoglobin count, packed cell volume, total white blood cell count, platelet count, neutrophil and lymphocyte count were assayed. Test results showed that the oral contraceptives had an increasingeffect on the haematological parameters. This increase was not dose dependent. The highest increase of 18.00 ± 1.40 vs control 14.30 ± 1.10 (g/dl) was obtained for Hb at the concentration of 0.72μg at 2 hours duration (p< 0.05).The blood PCV, WBC, platelet, neutrophil and lymphocyte analysis also showed increases. The possible implications of these findings on the female rat and by extrapolation on the female ‘homo sapiens’ are that laboratory tests involving full blood analysis should be undergone before these drugs are taken. Check-up tests should also be performed every six months, to identify women who might be at risk of developing minor or serious side effects that might affect major organs of the body.Keywords: Blood, ethinylestradiol, haematological parameters, lenonorgestrel, norethisterone, oral contraceptives |
format |
Article in Journal/Newspaper |
author |
Okoye, N.F. Uwakwe, A.A. |
author_facet |
Okoye, N.F. Uwakwe, A.A. |
author_sort |
Okoye, N.F. |
title |
Investigation into the effects of oral contraceptives on some haematological parameters of Wistar albino rat Rattus rattus |
title_short |
Investigation into the effects of oral contraceptives on some haematological parameters of Wistar albino rat Rattus rattus |
title_full |
Investigation into the effects of oral contraceptives on some haematological parameters of Wistar albino rat Rattus rattus |
title_fullStr |
Investigation into the effects of oral contraceptives on some haematological parameters of Wistar albino rat Rattus rattus |
title_full_unstemmed |
Investigation into the effects of oral contraceptives on some haematological parameters of Wistar albino rat Rattus rattus |
title_sort |
investigation into the effects of oral contraceptives on some haematological parameters of wistar albino rat rattus rattus |
publisher |
Faculty of Science, University of Port Harcourt Port Harcourt |
publishDate |
2017 |
url |
https://www.ajol.info/index.php/sa/article/view/156522 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Scientia Africana; Vol 15, No 2 (2016) 1118-1931 |
op_relation |
https://www.ajol.info/index.php/sa/article/view/156522/146132 https://www.ajol.info/index.php/sa/article/view/156522 |
op_rights |
Copyright is owned by the journal |
_version_ |
1766176798193745920 |