The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis
Background:By the year 2030, it will be seven more times difficult and seven times more of 14,600 pills to treat one person with drug resistant tuberculosis (TB) if we fail in the use of ‘Omics therapy’. A curated database of the National Centre for Biotechnology Institute (NCBI): Comprehensive Anti...
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ftjafricanj:oai:ajol.info:article/223904 2023-05-15T13:43:23+02:00 The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis Aderibigbe, Taiwo Micheal, Adeoti 2022-05-01 application/pdf https://www.ajol.info/index.php/mid/article/view/223904 eng eng Zagazig University Faculty of Medicine https://www.ajol.info/index.php/mid/article/view/223904/211223 https://www.ajol.info/index.php/mid/article/view/223904 Microbes and Infectious Diseases; Vol. 3 No. 2 (2022); 428-433 2682-4140 2682-4132 Omics CARD Mycobacterium tuberculosis Multi-Drugs Resistant Whole Genome Sequence info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article 2022 ftjafricanj 2022-05-01T00:23:47Z Background:By the year 2030, it will be seven more times difficult and seven times more of 14,600 pills to treat one person with drug resistant tuberculosis (TB) if we fail in the use of ‘Omics therapy’. A curated database of the National Centre for Biotechnology Institute (NCBI): Comprehensive Antibiotic Resistance Database (CARD) provides high-through-put referenced information on antibiotics resistance.Methods:This study employed a less expensive but high accuracy software-based approach; Comprehensive Antibiotics Resistance Database to identify the resistance genes within the genomes ofMycobacterium tuberculosisacross the five continents. Thirty complete genomes ofMycobacterium tuberculosiswere retrieved and their respective accession numbers and locations were categorized into Perfect and Strict genes.Results:The least number ofMycobacterium tuberculosiscomplete genome sequences were retrieved from the America followed by Antarctica and Africa with 10%, 10%, 25% prevalence respectively. The continents with the highest number of sequences were Asia and Europe which account for 25% and 33.3% respectively. The prevalence of genes categorized under the strict category from CARD database with mdsB, mdsA, AAC(6')-Iaa, sdiA, golS TEM-1, tetW , ANT(4')-Ib, had 100% prevalence each (present in all the 30 complete genome sequences retrieved), arlR, arlS, mepR, mgrA had the prevalence rates of 25%, each, mepA, Lmrs, FosB had the prevalence rates of 33.3% each. Article in Journal/Newspaper Antarc* Antarctica AJOL - African Journals Online |
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English |
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Omics CARD Mycobacterium tuberculosis Multi-Drugs Resistant Whole Genome Sequence |
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Omics CARD Mycobacterium tuberculosis Multi-Drugs Resistant Whole Genome Sequence Aderibigbe, Taiwo Micheal, Adeoti The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis |
topic_facet |
Omics CARD Mycobacterium tuberculosis Multi-Drugs Resistant Whole Genome Sequence |
description |
Background:By the year 2030, it will be seven more times difficult and seven times more of 14,600 pills to treat one person with drug resistant tuberculosis (TB) if we fail in the use of ‘Omics therapy’. A curated database of the National Centre for Biotechnology Institute (NCBI): Comprehensive Antibiotic Resistance Database (CARD) provides high-through-put referenced information on antibiotics resistance.Methods:This study employed a less expensive but high accuracy software-based approach; Comprehensive Antibiotics Resistance Database to identify the resistance genes within the genomes ofMycobacterium tuberculosisacross the five continents. Thirty complete genomes ofMycobacterium tuberculosiswere retrieved and their respective accession numbers and locations were categorized into Perfect and Strict genes.Results:The least number ofMycobacterium tuberculosiscomplete genome sequences were retrieved from the America followed by Antarctica and Africa with 10%, 10%, 25% prevalence respectively. The continents with the highest number of sequences were Asia and Europe which account for 25% and 33.3% respectively. The prevalence of genes categorized under the strict category from CARD database with mdsB, mdsA, AAC(6')-Iaa, sdiA, golS TEM-1, tetW , ANT(4')-Ib, had 100% prevalence each (present in all the 30 complete genome sequences retrieved), arlR, arlS, mepR, mgrA had the prevalence rates of 25%, each, mepA, Lmrs, FosB had the prevalence rates of 33.3% each. |
format |
Article in Journal/Newspaper |
author |
Aderibigbe, Taiwo Micheal, Adeoti |
author_facet |
Aderibigbe, Taiwo Micheal, Adeoti |
author_sort |
Aderibigbe, Taiwo |
title |
The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis |
title_short |
The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis |
title_full |
The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis |
title_fullStr |
The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis |
title_full_unstemmed |
The Intercontinental ‘Omics’ mining of Antibiotic Resistant Genes in Mycobacterium tuberculosis |
title_sort |
intercontinental ‘omics’ mining of antibiotic resistant genes in mycobacterium tuberculosis |
publisher |
Zagazig University Faculty of Medicine |
publishDate |
2022 |
url |
https://www.ajol.info/index.php/mid/article/view/223904 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Microbes and Infectious Diseases; Vol. 3 No. 2 (2022); 428-433 2682-4140 2682-4132 |
op_relation |
https://www.ajol.info/index.php/mid/article/view/223904/211223 https://www.ajol.info/index.php/mid/article/view/223904 |
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1766188508556296192 |