Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey
Background: The aim of the present study was to identify the epidemiological, clinical and laboratory features of Crimean-Congo hemorrhagic fever (CCHF) virus infection in children. Methods: Fifty children infected with CCHF virus in 20052010, and hospitalized in the Dr Sami Ulus Maternity and Child...
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ftistanbuluniv:oai:http://acikerisim.istanbul.edu.tr:20.500.12627/91878 2024-06-23T07:56:34+00:00 Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey Caglayik, Dilek Yagci Uyar, Yavuz TANIR, Gonul Korukluoglu, Gulay CENESIZ, Funda TUYGUN, Nilden Hacettepe Üniversitesi , , 87926 2012 https://hdl.handle.net/20.500.12627/91878 https://doi.org/10.1111/j.1442-200x.2011.03549.x eng eng PEDIATRICS INTERNATIONAL TUYGUN N., TANIR G., Caglayik D. Y. , Uyar Y., Korukluoglu G., CENESIZ F., "Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey", PEDIATRICS INTERNATIONAL, cilt.54, ss.402-406, 2012 1328-8067 vv_1032021 av_873ad79b-69d5-4953-9b8d-b168799ab24f http://hdl.handle.net/20.500.12627/91878 https://doi.org/10.1111/j.1442-200x.2011.03549.x 54 3 402 406 Çocuk Sağlığı ve Hastalıkları Dahili Tıp Bilimleri Sağlık Bilimleri Tıp Klinik Tıp (MED) Klinik Tıp PEDİATRİ Makale 2012 ftistanbuluniv https://doi.org/20.500.12627/9187810.1111/j.1442-200x.2011.03549.x 2024-06-06T04:07:48Z Background: The aim of the present study was to identify the epidemiological, clinical and laboratory features of Crimean-Congo hemorrhagic fever (CCHF) virus infection in children. Methods: Fifty children infected with CCHF virus in 20052010, and hospitalized in the Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital in Ankara, were included. All the patients had positive IgM and/or polymerase chain reaction for CCHF virus. Results: Of the 50 patients, 19 were female and 31 were male. Patients were between 8 months and 15 years of age. The majority (82%) of patients had a history of tick bite. Fever (100%), hemorrhagic symptoms (76%), nauseavomiting (60%), tonsillopharyngitis (50%), malaise (50%), myalgia (46%) and maculopapular rash (24%) were the most common presenting clinical features. Mean platelet count on admission was 110 880/mm3, and the lowest was 7000/mm3. The mean of the lowest white blood cell count was 2860/mm3. Other pathological laboratory findings (asparate aminotransferase, alanine aminotransferase, lactate dehydrogenase and creatine kinase) were elevated, and prothrombin time and activated partial thromboplastin time were prolonged. Twenty-three patients (46%) were given ribavirin. No side-effect of ribavirin was seen. No patient died because of CCHF disease. Conclusion: CCHF virus infections are seen mostly in boys and school children and the adolescent age group. Tick bite is the major risk factor. Fever and hemorrhage are the most frequent presenting symptoms. Tonsillopharyngitis and rash on face or body are probably the most remarkable clinical findings in this disease. The CCHF disease course in Turkey may be mild in children. Article in Journal/Newspaper sami İstanbul Üniversitesi Açık Erişim Sistemi Pediatrics International 54 3 402 406 |
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İstanbul Üniversitesi Açık Erişim Sistemi |
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ftistanbuluniv |
language |
English |
topic |
Çocuk Sağlığı ve Hastalıkları Dahili Tıp Bilimleri Sağlık Bilimleri Tıp Klinik Tıp (MED) Klinik Tıp PEDİATRİ |
spellingShingle |
Çocuk Sağlığı ve Hastalıkları Dahili Tıp Bilimleri Sağlık Bilimleri Tıp Klinik Tıp (MED) Klinik Tıp PEDİATRİ Caglayik, Dilek Yagci Uyar, Yavuz TANIR, Gonul Korukluoglu, Gulay CENESIZ, Funda TUYGUN, Nilden Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey |
topic_facet |
Çocuk Sağlığı ve Hastalıkları Dahili Tıp Bilimleri Sağlık Bilimleri Tıp Klinik Tıp (MED) Klinik Tıp PEDİATRİ |
description |
Background: The aim of the present study was to identify the epidemiological, clinical and laboratory features of Crimean-Congo hemorrhagic fever (CCHF) virus infection in children. Methods: Fifty children infected with CCHF virus in 20052010, and hospitalized in the Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital in Ankara, were included. All the patients had positive IgM and/or polymerase chain reaction for CCHF virus. Results: Of the 50 patients, 19 were female and 31 were male. Patients were between 8 months and 15 years of age. The majority (82%) of patients had a history of tick bite. Fever (100%), hemorrhagic symptoms (76%), nauseavomiting (60%), tonsillopharyngitis (50%), malaise (50%), myalgia (46%) and maculopapular rash (24%) were the most common presenting clinical features. Mean platelet count on admission was 110 880/mm3, and the lowest was 7000/mm3. The mean of the lowest white blood cell count was 2860/mm3. Other pathological laboratory findings (asparate aminotransferase, alanine aminotransferase, lactate dehydrogenase and creatine kinase) were elevated, and prothrombin time and activated partial thromboplastin time were prolonged. Twenty-three patients (46%) were given ribavirin. No side-effect of ribavirin was seen. No patient died because of CCHF disease. Conclusion: CCHF virus infections are seen mostly in boys and school children and the adolescent age group. Tick bite is the major risk factor. Fever and hemorrhage are the most frequent presenting symptoms. Tonsillopharyngitis and rash on face or body are probably the most remarkable clinical findings in this disease. The CCHF disease course in Turkey may be mild in children. |
author2 |
Hacettepe Üniversitesi , , 87926 |
format |
Article in Journal/Newspaper |
author |
Caglayik, Dilek Yagci Uyar, Yavuz TANIR, Gonul Korukluoglu, Gulay CENESIZ, Funda TUYGUN, Nilden |
author_facet |
Caglayik, Dilek Yagci Uyar, Yavuz TANIR, Gonul Korukluoglu, Gulay CENESIZ, Funda TUYGUN, Nilden |
author_sort |
Caglayik, Dilek Yagci |
title |
Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey |
title_short |
Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey |
title_full |
Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey |
title_fullStr |
Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey |
title_full_unstemmed |
Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey |
title_sort |
pediatric cases of crimean-congo hemorrhagic fever in turkey |
publishDate |
2012 |
url |
https://hdl.handle.net/20.500.12627/91878 https://doi.org/10.1111/j.1442-200x.2011.03549.x |
genre |
sami |
genre_facet |
sami |
op_relation |
PEDIATRICS INTERNATIONAL TUYGUN N., TANIR G., Caglayik D. Y. , Uyar Y., Korukluoglu G., CENESIZ F., "Pediatric cases of Crimean-Congo hemorrhagic fever in Turkey", PEDIATRICS INTERNATIONAL, cilt.54, ss.402-406, 2012 1328-8067 vv_1032021 av_873ad79b-69d5-4953-9b8d-b168799ab24f http://hdl.handle.net/20.500.12627/91878 https://doi.org/10.1111/j.1442-200x.2011.03549.x 54 3 402 406 |
op_doi |
https://doi.org/20.500.12627/9187810.1111/j.1442-200x.2011.03549.x |
container_title |
Pediatrics International |
container_volume |
54 |
container_issue |
3 |
container_start_page |
402 |
op_container_end_page |
406 |
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1802649757108142080 |