Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro
Mollusc shells are composed of more than 95% calcium carbonate and less than 5% organic matrix consisting mostly of proteins, glycoproteins and polysaccharides. In this study, we investigated the effects of matrix macromolecular components extracted from the shells of two edible molluscs of economic...
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ftird:oai:ird.fr:fdi:010071019 2023-05-15T15:58:41+02:00 Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro Latire, T. Legendre, F. Bouyoucef, M. Marin, Frédéric Carreiras, F. Rigot-Jolivet, M. Lebel, J. M. Galera, P. Serpentini, A. 2017 http://www.documentation.ird.fr/hor/fdi:010071019 EN eng http://www.documentation.ird.fr/hor/fdi:010071019 oai:ird.fr:fdi:010071019 Latire T., Legendre F., Bouyoucef M., Marin Frédéric, Carreiras F., Rigot-Jolivet M., Lebel J. M., Galera P., Serpentini A. Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro. Cytotechnology, 2017, 69 (5), p. 815-829. Biological activity Extracellular matrix Fibroblast Mollusc Shell matrix text 2017 ftird 2020-08-21T06:50:28Z Mollusc shells are composed of more than 95% calcium carbonate and less than 5% organic matrix consisting mostly of proteins, glycoproteins and polysaccharides. In this study, we investigated the effects of matrix macromolecular components extracted from the shells of two edible molluscs of economic interest, i.e., the blue mussel Mytilus edulis and the Pacific oyster Crassostrea gigas. The potential biological activities of these organic molecules were analysed on human dermal fibroblasts in primary culture. Our results demonstrate that shell extracts of the two studied molluscs modulate the metabolic activities of the cells. In addition, the extracts caused a decrease of type I collagen and a concomitant increase of active MMP-1, both at the mRNA and the protein levels. Therefore, our results suggest that shell extracts from M. edulis and C. gigas contain molecules that promote the catabolic pathway of human dermal fibroblasts. This work emphasises the potential use of these shell matrices in the context of anti-fibrotic strategies, particularly against scleroderma. More generally, it stresses the usefulness to valorise bivalve shells that are coproducts of shellfish farming activity. Text Crassostrea gigas Pacific oyster IRD (Institute de recherche pour le développement): Horizon Pacific |
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IRD (Institute de recherche pour le développement): Horizon |
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language |
English |
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Biological activity Extracellular matrix Fibroblast Mollusc Shell matrix |
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Biological activity Extracellular matrix Fibroblast Mollusc Shell matrix Latire, T. Legendre, F. Bouyoucef, M. Marin, Frédéric Carreiras, F. Rigot-Jolivet, M. Lebel, J. M. Galera, P. Serpentini, A. Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro |
topic_facet |
Biological activity Extracellular matrix Fibroblast Mollusc Shell matrix |
description |
Mollusc shells are composed of more than 95% calcium carbonate and less than 5% organic matrix consisting mostly of proteins, glycoproteins and polysaccharides. In this study, we investigated the effects of matrix macromolecular components extracted from the shells of two edible molluscs of economic interest, i.e., the blue mussel Mytilus edulis and the Pacific oyster Crassostrea gigas. The potential biological activities of these organic molecules were analysed on human dermal fibroblasts in primary culture. Our results demonstrate that shell extracts of the two studied molluscs modulate the metabolic activities of the cells. In addition, the extracts caused a decrease of type I collagen and a concomitant increase of active MMP-1, both at the mRNA and the protein levels. Therefore, our results suggest that shell extracts from M. edulis and C. gigas contain molecules that promote the catabolic pathway of human dermal fibroblasts. This work emphasises the potential use of these shell matrices in the context of anti-fibrotic strategies, particularly against scleroderma. More generally, it stresses the usefulness to valorise bivalve shells that are coproducts of shellfish farming activity. |
format |
Text |
author |
Latire, T. Legendre, F. Bouyoucef, M. Marin, Frédéric Carreiras, F. Rigot-Jolivet, M. Lebel, J. M. Galera, P. Serpentini, A. |
author_facet |
Latire, T. Legendre, F. Bouyoucef, M. Marin, Frédéric Carreiras, F. Rigot-Jolivet, M. Lebel, J. M. Galera, P. Serpentini, A. |
author_sort |
Latire, T. |
title |
Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro |
title_short |
Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro |
title_full |
Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro |
title_fullStr |
Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro |
title_full_unstemmed |
Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro |
title_sort |
shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro |
publishDate |
2017 |
url |
http://www.documentation.ird.fr/hor/fdi:010071019 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
http://www.documentation.ird.fr/hor/fdi:010071019 oai:ird.fr:fdi:010071019 Latire T., Legendre F., Bouyoucef M., Marin Frédéric, Carreiras F., Rigot-Jolivet M., Lebel J. M., Galera P., Serpentini A. Shell extracts of the edible mussel and oyster induce an enhancement of the catabolic pathway of human skin fibroblasts, in vitro. Cytotechnology, 2017, 69 (5), p. 815-829. |
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1766394447566733312 |