Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses
One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain larg...
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ftird:oai:ird.fr:fdi:010070080 2023-05-15T18:05:21+02:00 Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses Ghawar, W. Pascalis, H. Bettaieb, J. Melade, J. Gharbi, A. Snoussi, M. A. Laouini, D. Goodman, S. M. Ben Salah, A. Dellagi, Koussay TUNISIE ZAMBIE AFRIQUE DU SUD TRINITE ET TOBAGO CHINE AUSTRALIE ALLEMAGNE MADAGASCAR REUNION SEYCHELLES 2017 text/pdf http://www.documentation.ird.fr/hor/fdi:010070080 EN eng http://www.documentation.ird.fr/hor/fdi:010070080 oai:ird.fr:fdi:010070080 Ghawar W., Pascalis H., Bettaieb J., Melade J., Gharbi A., Snoussi M. A., Laouini D., Goodman S. M., Ben Salah A., Dellagi Koussay. Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses. Scientific Reports - Nature, 2017, 7, p. art. 1974 [12 p.]. text 2017 ftird 2020-08-21T06:50:47Z One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain largely unstudied. The present study revealed, for the first time, that Rodentia associated UMRV emerged from a common ancestor in southern Africa more than 4000 years ago. Sequenced UMRV originating from different regions in the world, clustered into four well-supported viral lineages, which suggest that strain diversification occurred during host dispersal and associated exchanges, with purifying selection pressure as the principal evolutionary force. In addition, multi-introductions on different continents and islands of Rodentia associated UMRV and spillover between rodent species, most probably Rattus rattus, were detected and indicate that these animals are implicated in the vectoring and in the worldwide emergence of this virus group. The natural history and the evolution dynamics of these zoonotic viruses, originating from and hosted by wild animals, are most likely shaped by commensalism related to human activities. Text Rattus rattus IRD (Institute de recherche pour le développement): Horizon |
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IRD (Institute de recherche pour le développement): Horizon |
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One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain largely unstudied. The present study revealed, for the first time, that Rodentia associated UMRV emerged from a common ancestor in southern Africa more than 4000 years ago. Sequenced UMRV originating from different regions in the world, clustered into four well-supported viral lineages, which suggest that strain diversification occurred during host dispersal and associated exchanges, with purifying selection pressure as the principal evolutionary force. In addition, multi-introductions on different continents and islands of Rodentia associated UMRV and spillover between rodent species, most probably Rattus rattus, were detected and indicate that these animals are implicated in the vectoring and in the worldwide emergence of this virus group. The natural history and the evolution dynamics of these zoonotic viruses, originating from and hosted by wild animals, are most likely shaped by commensalism related to human activities. |
format |
Text |
author |
Ghawar, W. Pascalis, H. Bettaieb, J. Melade, J. Gharbi, A. Snoussi, M. A. Laouini, D. Goodman, S. M. Ben Salah, A. Dellagi, Koussay |
spellingShingle |
Ghawar, W. Pascalis, H. Bettaieb, J. Melade, J. Gharbi, A. Snoussi, M. A. Laouini, D. Goodman, S. M. Ben Salah, A. Dellagi, Koussay Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
author_facet |
Ghawar, W. Pascalis, H. Bettaieb, J. Melade, J. Gharbi, A. Snoussi, M. A. Laouini, D. Goodman, S. M. Ben Salah, A. Dellagi, Koussay |
author_sort |
Ghawar, W. |
title |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_short |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_full |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_fullStr |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_full_unstemmed |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_sort |
insight into the global evolution of rodentia associated morbilli-related paramyxoviruses |
publishDate |
2017 |
url |
http://www.documentation.ird.fr/hor/fdi:010070080 |
op_coverage |
TUNISIE ZAMBIE AFRIQUE DU SUD TRINITE ET TOBAGO CHINE AUSTRALIE ALLEMAGNE MADAGASCAR REUNION SEYCHELLES |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
http://www.documentation.ird.fr/hor/fdi:010070080 oai:ird.fr:fdi:010070080 Ghawar W., Pascalis H., Bettaieb J., Melade J., Gharbi A., Snoussi M. A., Laouini D., Goodman S. M., Ben Salah A., Dellagi Koussay. Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses. Scientific Reports - Nature, 2017, 7, p. art. 1974 [12 p.]. |
_version_ |
1766176811297800192 |