CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar
Madagascar remains one of the world's largest plague foci. The black rat, Rattus rattus, is the main reservoir of plague in rural areas. This species is highly susceptible to plague in plague-free areas (low-altitude regions), whereas rats from the plague focus areas (central highlands) have ev...
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ftird:oai:ird.fr:fdi:010044159 2024-09-09T20:05:00+00:00 CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar Tollenaere, C. Rahalison, L. Ranjalahy, M. Rahelinirina, S. /Duplantier, Jean-Marc /Brouat, Carine 2008 https://www.documentation.ird.fr/hor/fdi:010044159 EN eng https://www.documentation.ird.fr/hor/fdi:010044159 oai:ird.fr:fdi:010044159 Tollenaere C., Rahalison L., Ranjalahy M., Rahelinirina S., Duplantier Jean-Marc, Brouat Carine. CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar. 2008, 8 (6), p. 891-897 Infectious disease resistance Yersinia pestis Chemokine receptor Candidate gene Immunogenetics text 2008 ftird 2024-08-15T05:57:42Z Madagascar remains one of the world's largest plague foci. The black rat, Rattus rattus, is the main reservoir of plague in rural areas. This species is highly susceptible to plague in plague-free areas (low-altitude regions), whereas rats from the plague focus areas (central highlands) have evolved a disease-resistance polymorphism. We used the candidate gene CCR5 to investigate the genetic basis of plague resistance in R. rattus. We found a unique non-synonymous substitution (H184R) in a functionally important region of the gene. We then compared (i) CCR5 genotypes of dying and surviving plague-challenged rats and (ii) CCR5 allelic frequencies in plague focus and plague-free populations. Our results suggested a higher prevalence of the substitution in resistant animals compared to susceptible individuals, and a tendency for higher frequencies in plague focus areas compared to plague-free areas. Therefore, the CCR5 polymorphism may be involved in Malagasy black rat plague resistance. CCR5 and other undetermined plague resistance markers may provide useful biological information about host evolution and disease dynamics. Text Rattus rattus IRD (Institute de recherche pour le développement): Horizon |
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IRD (Institute de recherche pour le développement): Horizon |
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English |
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Infectious disease resistance Yersinia pestis Chemokine receptor Candidate gene Immunogenetics |
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Infectious disease resistance Yersinia pestis Chemokine receptor Candidate gene Immunogenetics Tollenaere, C. Rahalison, L. Ranjalahy, M. Rahelinirina, S. /Duplantier, Jean-Marc /Brouat, Carine CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar |
topic_facet |
Infectious disease resistance Yersinia pestis Chemokine receptor Candidate gene Immunogenetics |
description |
Madagascar remains one of the world's largest plague foci. The black rat, Rattus rattus, is the main reservoir of plague in rural areas. This species is highly susceptible to plague in plague-free areas (low-altitude regions), whereas rats from the plague focus areas (central highlands) have evolved a disease-resistance polymorphism. We used the candidate gene CCR5 to investigate the genetic basis of plague resistance in R. rattus. We found a unique non-synonymous substitution (H184R) in a functionally important region of the gene. We then compared (i) CCR5 genotypes of dying and surviving plague-challenged rats and (ii) CCR5 allelic frequencies in plague focus and plague-free populations. Our results suggested a higher prevalence of the substitution in resistant animals compared to susceptible individuals, and a tendency for higher frequencies in plague focus areas compared to plague-free areas. Therefore, the CCR5 polymorphism may be involved in Malagasy black rat plague resistance. CCR5 and other undetermined plague resistance markers may provide useful biological information about host evolution and disease dynamics. |
format |
Text |
author |
Tollenaere, C. Rahalison, L. Ranjalahy, M. Rahelinirina, S. /Duplantier, Jean-Marc /Brouat, Carine |
author_facet |
Tollenaere, C. Rahalison, L. Ranjalahy, M. Rahelinirina, S. /Duplantier, Jean-Marc /Brouat, Carine |
author_sort |
Tollenaere, C. |
title |
CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar |
title_short |
CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar |
title_full |
CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar |
title_fullStr |
CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar |
title_full_unstemmed |
CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar |
title_sort |
ccr5 polymorphism and plague resistance in natural populations of the black rat in madagascar |
publishDate |
2008 |
url |
https://www.documentation.ird.fr/hor/fdi:010044159 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
https://www.documentation.ird.fr/hor/fdi:010044159 oai:ird.fr:fdi:010044159 Tollenaere C., Rahalison L., Ranjalahy M., Rahelinirina S., Duplantier Jean-Marc, Brouat Carine. CCR5 polymorphism and plague resistance in natural populations of the black rat in Madagascar. 2008, 8 (6), p. 891-897 |
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