Factors correlating with significant differences between X-ray structures of myoglobin

• Main Authors: Rashin, Alexander A, Domagalski, Marcin J, Zimmermann, Michael T, Minor, Wladek, Chruszcz, Maksymilian, Jernigan, Robert L
• Format: Text
• Language: English
• Published: Iowa State University Digital Repository 2014
• Subjects: Biochemistry; Bioinformatics; Biophysics; Molecular Biology; Structural Biology; Holo; Sperm whale
• Online Access: https://lib.dr.iastate.edu/bbmb_ag_pubs/162; https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1170&context=bbmb_ag_pubs

Validation of general ideas about the origins of conformational differences in proteins is critical in order to arrive at meaningful functional insights. Here, principal component analysis (PCA) and distance difference matrices are used to validate some such ideas about the conformational difference...