The Extracellular Matrix of the Human and Whale Cornea and Sclera: Implications in Glaucoma and Other Pathologies
The cornea is the transparent part of the eye that allows light to enter into the eye and reach the retina, thereby activating the neurons that will send messages to the brain. The sclera is the hard-white part of the eye, and its main function is to provide structure and form to the eye, and to sup...
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ftintech:oai:intechopen.com:75952 2023-05-15T15:36:39+02:00 The Extracellular Matrix of the Human and Whale Cornea and Sclera: Implications in Glaucoma and Other Pathologies Vecino, Elena Ruzafa, Noelia Pereiro, Xandra Zulueta, Ane Sarmiento, Alfredo Díez, Alejandro 2021-03-26 https://mts.intechopen.com/articles/show/title/the-extracellular-matrix-of-the-human-and-whale-cornea-and-sclera-implications-in-glaucoma-and-other https://doi.org/10.5772/intechopen.97023 en eng IntechOpen ISBN:978-1-83968-235-3 https://mts.intechopen.com/articles/show/title/the-extracellular-matrix-of-the-human-and-whale-cornea-and-sclera-implications-in-glaucoma-and-other doi:10.5772/intechopen.97023 https://creativecommons.org/licenses/by/3.0/ CC-BY https://www.intechopen.com/books/8018 Extracellular Matrix - Developments and Therapeutics Chapter, Part Of Book 2021 ftintech https://doi.org/10.5772/intechopen.97023 2021-11-13T20:06:09Z The cornea is the transparent part of the eye that allows light to enter into the eye and reach the retina, thereby activating the neurons that will send messages to the brain. The sclera is the hard-white part of the eye, and its main function is to provide structure and form to the eye, and to support the retina. Indeed, while the cornea best performs its main functions when transparent and it is capable of adapting its curvature to allow the eye to focus, the sclera must be opaque and hard to function correctly. Both structures are mainly composed of collagen, some elastic fibres and ground substance, all components of the Extracellular Matrix. The disposition of the collagen fibres and the amount of ground substance around the fibres is responsible for the differences in the aspect of both these structures. In this chapter, for the first time we have compared the structure and ultrastructure of the cornea and sclera in humans and the whale adult (18mts) Balaenoptera physalus, the second largest animal on the planet. We will discuss how the differences in their structure may be related to the maintenance of intraocular pressure in their distinct environments, which is of particular clinical interest as increased intraocular pressure is one of the main causes underlying the development of open angle glaucoma. Other/Unknown Material Balaenoptera physalus IntechOpen (E-Books) |
institution |
Open Polar |
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IntechOpen (E-Books) |
op_collection_id |
ftintech |
language |
English |
topic |
Extracellular Matrix - Developments and Therapeutics |
spellingShingle |
Extracellular Matrix - Developments and Therapeutics Vecino, Elena Ruzafa, Noelia Pereiro, Xandra Zulueta, Ane Sarmiento, Alfredo Díez, Alejandro The Extracellular Matrix of the Human and Whale Cornea and Sclera: Implications in Glaucoma and Other Pathologies |
topic_facet |
Extracellular Matrix - Developments and Therapeutics |
description |
The cornea is the transparent part of the eye that allows light to enter into the eye and reach the retina, thereby activating the neurons that will send messages to the brain. The sclera is the hard-white part of the eye, and its main function is to provide structure and form to the eye, and to support the retina. Indeed, while the cornea best performs its main functions when transparent and it is capable of adapting its curvature to allow the eye to focus, the sclera must be opaque and hard to function correctly. Both structures are mainly composed of collagen, some elastic fibres and ground substance, all components of the Extracellular Matrix. The disposition of the collagen fibres and the amount of ground substance around the fibres is responsible for the differences in the aspect of both these structures. In this chapter, for the first time we have compared the structure and ultrastructure of the cornea and sclera in humans and the whale adult (18mts) Balaenoptera physalus, the second largest animal on the planet. We will discuss how the differences in their structure may be related to the maintenance of intraocular pressure in their distinct environments, which is of particular clinical interest as increased intraocular pressure is one of the main causes underlying the development of open angle glaucoma. |
format |
Other/Unknown Material |
author |
Vecino, Elena Ruzafa, Noelia Pereiro, Xandra Zulueta, Ane Sarmiento, Alfredo Díez, Alejandro |
author_facet |
Vecino, Elena Ruzafa, Noelia Pereiro, Xandra Zulueta, Ane Sarmiento, Alfredo Díez, Alejandro |
author_sort |
Vecino, Elena |
title |
The Extracellular Matrix of the Human and Whale Cornea and Sclera: Implications in Glaucoma and Other Pathologies |
title_short |
The Extracellular Matrix of the Human and Whale Cornea and Sclera: Implications in Glaucoma and Other Pathologies |
title_full |
The Extracellular Matrix of the Human and Whale Cornea and Sclera: Implications in Glaucoma and Other Pathologies |
title_fullStr |
The Extracellular Matrix of the Human and Whale Cornea and Sclera: Implications in Glaucoma and Other Pathologies |
title_full_unstemmed |
The Extracellular Matrix of the Human and Whale Cornea and Sclera: Implications in Glaucoma and Other Pathologies |
title_sort |
extracellular matrix of the human and whale cornea and sclera: implications in glaucoma and other pathologies |
publisher |
IntechOpen |
publishDate |
2021 |
url |
https://mts.intechopen.com/articles/show/title/the-extracellular-matrix-of-the-human-and-whale-cornea-and-sclera-implications-in-glaucoma-and-other https://doi.org/10.5772/intechopen.97023 |
genre |
Balaenoptera physalus |
genre_facet |
Balaenoptera physalus |
op_source |
https://www.intechopen.com/books/8018 |
op_relation |
ISBN:978-1-83968-235-3 https://mts.intechopen.com/articles/show/title/the-extracellular-matrix-of-the-human-and-whale-cornea-and-sclera-implications-in-glaucoma-and-other doi:10.5772/intechopen.97023 |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.5772/intechopen.97023 |
_version_ |
1766367020935282688 |