Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity
Rutin was enzymatically acylated with hexadecanedioic acid, in tert‐amyl alcohol, by an immobilized lipase from Candida antartica “Novozym 435”. The effect of different techniques of water removal, temperature, concentration of rutin and diacid/rutin molar ratio was investigated. The obtained result...
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ftintech:oai:intechopen.com:54365 2023-05-15T14:15:23+02:00 Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity Slimane, Manel Cordin, Aude Ghoul, Mohamed Latifa, Chebil 2017-08-23 https://mts.intechopen.com/articles/show/title/biocatalysis-of-rutin-hexadecanedioate-derivatives-effect-of-operating-conditions-on-acylation-perfo https://doi.org/10.5772/67621 en eng IntechOpen ISBN:978-953-51-3423-7 https://mts.intechopen.com/articles/show/title/biocatalysis-of-rutin-hexadecanedioate-derivatives-effect-of-operating-conditions-on-acylation-perfo doi:10.5772/67621 https://creativecommons.org/licenses/by/3.0/ CC-BY https://www.intechopen.com/books/5828 Flavonoids - From Biosynthesis to Human Health Chapter, Part Of Book 2017 ftintech https://doi.org/10.5772/67621 2021-11-13T19:07:58Z Rutin was enzymatically acylated with hexadecanedioic acid, in tert‐amyl alcohol, by an immobilized lipase from Candida antartica “Novozym 435”. The effect of different techniques of water removal, temperature, concentration of rutin and diacid/rutin molar ratio was investigated. The obtained results indicated that drying the media by adding the molecular sieves in the outer loop of the reactor was the most efficient method leading to water content lower than 200 ppm. The highest performances (conversion yield and initial rate) were reached at 90°C, 131 mM of rutin, and 118 mM of acid. Depending on the water content and the diacid/rutin molar ratio, only rutin 4‴‐hexadecanedioate or both rutin 4‴‐hexadecanedioate and dirutin 4‴, 4‴‐hexadecanedioate were synthesized. Other/Unknown Material antartic* IntechOpen (E-Books) |
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IntechOpen (E-Books) |
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language |
English |
topic |
Flavonoids - From Biosynthesis to Human Health |
spellingShingle |
Flavonoids - From Biosynthesis to Human Health Slimane, Manel Cordin, Aude Ghoul, Mohamed Latifa, Chebil Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
topic_facet |
Flavonoids - From Biosynthesis to Human Health |
description |
Rutin was enzymatically acylated with hexadecanedioic acid, in tert‐amyl alcohol, by an immobilized lipase from Candida antartica “Novozym 435”. The effect of different techniques of water removal, temperature, concentration of rutin and diacid/rutin molar ratio was investigated. The obtained results indicated that drying the media by adding the molecular sieves in the outer loop of the reactor was the most efficient method leading to water content lower than 200 ppm. The highest performances (conversion yield and initial rate) were reached at 90°C, 131 mM of rutin, and 118 mM of acid. Depending on the water content and the diacid/rutin molar ratio, only rutin 4‴‐hexadecanedioate or both rutin 4‴‐hexadecanedioate and dirutin 4‴, 4‴‐hexadecanedioate were synthesized. |
format |
Other/Unknown Material |
author |
Slimane, Manel Cordin, Aude Ghoul, Mohamed Latifa, Chebil |
author_facet |
Slimane, Manel Cordin, Aude Ghoul, Mohamed Latifa, Chebil |
author_sort |
Slimane, Manel |
title |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_short |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_full |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_fullStr |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_full_unstemmed |
Biocatalysis of Rutin Hexadecanedioate Derivatives: Effect of Operating Conditions on Acylation Performance and Selectivity |
title_sort |
biocatalysis of rutin hexadecanedioate derivatives: effect of operating conditions on acylation performance and selectivity |
publisher |
IntechOpen |
publishDate |
2017 |
url |
https://mts.intechopen.com/articles/show/title/biocatalysis-of-rutin-hexadecanedioate-derivatives-effect-of-operating-conditions-on-acylation-perfo https://doi.org/10.5772/67621 |
genre |
antartic* |
genre_facet |
antartic* |
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https://www.intechopen.com/books/5828 |
op_relation |
ISBN:978-953-51-3423-7 https://mts.intechopen.com/articles/show/title/biocatalysis-of-rutin-hexadecanedioate-derivatives-effect-of-operating-conditions-on-acylation-perfo doi:10.5772/67621 |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.5772/67621 |
_version_ |
1766287785642164224 |