Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters
International audience Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a...
Published in: | Nature Communications |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Other Authors: | , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2018
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Subjects: | |
Online Access: | https://hal.science/hal-01898110 https://hal.science/hal-01898110/document https://hal.science/hal-01898110/file/Lorgeril-2018-NatCom-Immune.pdf https://doi.org/10.1038/s41467-018-06659-3 |
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ftinsu:oai:HAL:hal-01898110v1 |
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openpolar |
institution |
Open Polar |
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Institut national des sciences de l'Univers: HAL-INSU |
op_collection_id |
ftinsu |
language |
English |
topic |
MU-VAR MORTALITY CRASSOSTREA-GIGAS HERPES-VIRUS TEMPERATURE FRANCE IRELAND ACL ANTIVIRAL RESPONSE OSTREID HERPESVIRUS-1 READ ALIGNMENT [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health [SDE.BE]Environmental Sciences/Biodiversity and Ecology |
spellingShingle |
MU-VAR MORTALITY CRASSOSTREA-GIGAS HERPES-VIRUS TEMPERATURE FRANCE IRELAND ACL ANTIVIRAL RESPONSE OSTREID HERPESVIRUS-1 READ ALIGNMENT [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health [SDE.BE]Environmental Sciences/Biodiversity and Ecology de Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-Dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean-Michel Haffner, Philippe Degrémont, Lionel, L. Charrière, Guillaume Lafont, Maxime Delort, Abigaïl Vergnes, Agnès Chiarello, Marlène Faury, Nicole Rubio, Tristan Leroy, Marc Pérignon, Adeline Régler, Denis Morga, Benjamin Alunno-Bruscia, Marianne Boudry, Pierre Le Roux, Frédérique Destoumieux-Garzon, Delphine Gueguen, Yannick Mitta, Guillaume Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
topic_facet |
MU-VAR MORTALITY CRASSOSTREA-GIGAS HERPES-VIRUS TEMPERATURE FRANCE IRELAND ACL ANTIVIRAL RESPONSE OSTREID HERPESVIRUS-1 READ ALIGNMENT [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health [SDE.BE]Environmental Sciences/Biodiversity and Ecology |
description |
International audience Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. |
author2 |
Interactions Hôtes-Pathogènes-Environnements (IHPE) Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR) Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM) Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) Laboratoire de Génétique et Pathologie des Mollusques Marins (LGPMM) Unité Santé, Génétique et Microbiologie des Mollusques (SGMM) Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) MARine Biodiversity Exploitation and Conservation (UMR MARBEC) Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) Comité de la Conchyliculture de Méditerranée (CRCM) Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M) Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff = Roscoff Marine Station (SBR) Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) Station biologique de Roscoff = Roscoff Marine Station (SBR) Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ANR-14-CE19-0023,DECIPHER,Déchiffrage des maladies multifactorielles: cas des mortalités de l'huître(2014) ANR-10-LABX-0004,CeMEB,Mediterranean Center for Environment and Biodiversity(2010) European Project: 678589,H2020,H2020-SFS-2015-2,VIVALDI(2016) |
format |
Article in Journal/Newspaper |
author |
de Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-Dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean-Michel Haffner, Philippe Degrémont, Lionel, L. Charrière, Guillaume Lafont, Maxime Delort, Abigaïl Vergnes, Agnès Chiarello, Marlène Faury, Nicole Rubio, Tristan Leroy, Marc Pérignon, Adeline Régler, Denis Morga, Benjamin Alunno-Bruscia, Marianne Boudry, Pierre Le Roux, Frédérique Destoumieux-Garzon, Delphine Gueguen, Yannick Mitta, Guillaume |
author_facet |
de Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-Dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean-Michel Haffner, Philippe Degrémont, Lionel, L. Charrière, Guillaume Lafont, Maxime Delort, Abigaïl Vergnes, Agnès Chiarello, Marlène Faury, Nicole Rubio, Tristan Leroy, Marc Pérignon, Adeline Régler, Denis Morga, Benjamin Alunno-Bruscia, Marianne Boudry, Pierre Le Roux, Frédérique Destoumieux-Garzon, Delphine Gueguen, Yannick Mitta, Guillaume |
author_sort |
de Lorgeril, Julien |
title |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_short |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_full |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_fullStr |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_full_unstemmed |
Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters |
title_sort |
immune-suppression by oshv-1 viral infection causes fatal bacteraemia in pacific oysters |
publisher |
HAL CCSD |
publishDate |
2018 |
url |
https://hal.science/hal-01898110 https://hal.science/hal-01898110/document https://hal.science/hal-01898110/file/Lorgeril-2018-NatCom-Immune.pdf https://doi.org/10.1038/s41467-018-06659-3 |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
ISSN: 2041-1723 EISSN: 2041-1723 Nature Communications https://hal.science/hal-01898110 Nature Communications, 2018, 9 (1), pp.4215. ⟨10.1038/s41467-018-06659-3⟩ https://www.nature.com/articles/s41467-018-06659-3 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-018-06659-3 info:eu-repo/grantAgreement//678589/EU/Preventing and mitigating farmed bivalve diseases/VIVALDI hal-01898110 https://hal.science/hal-01898110 https://hal.science/hal-01898110/document https://hal.science/hal-01898110/file/Lorgeril-2018-NatCom-Immune.pdf doi:10.1038/s41467-018-06659-3 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1038/s41467-018-06659-3 |
container_title |
Nature Communications |
container_volume |
9 |
container_issue |
1 |
_version_ |
1796941064781692928 |
spelling |
ftinsu:oai:HAL:hal-01898110v1 2024-04-21T08:00:36+00:00 Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters de Lorgeril, Julien Lucasson, Aude Petton, Bruno Toulza, Eve Montagnani, Caroline Clerissi, Camille Vidal-Dupiol, Jeremie Chaparro, Cristian Galinier, Richard Escoubas, Jean-Michel Haffner, Philippe Degrémont, Lionel, L. Charrière, Guillaume Lafont, Maxime Delort, Abigaïl Vergnes, Agnès Chiarello, Marlène Faury, Nicole Rubio, Tristan Leroy, Marc Pérignon, Adeline Régler, Denis Morga, Benjamin Alunno-Bruscia, Marianne Boudry, Pierre Le Roux, Frédérique Destoumieux-Garzon, Delphine Gueguen, Yannick Mitta, Guillaume Interactions Hôtes-Pathogènes-Environnements (IHPE) Université de Perpignan Via Domitia (UPVD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR) Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM) Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) Laboratoire de Génétique et Pathologie des Mollusques Marins (LGPMM) Unité Santé, Génétique et Microbiologie des Mollusques (SGMM) Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) MARine Biodiversity Exploitation and Conservation (UMR MARBEC) Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) Comité de la Conchyliculture de Méditerranée (CRCM) Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M) Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff = Roscoff Marine Station (SBR) Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) Station biologique de Roscoff = Roscoff Marine Station (SBR) Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ANR-14-CE19-0023,DECIPHER,Déchiffrage des maladies multifactorielles: cas des mortalités de l'huître(2014) ANR-10-LABX-0004,CeMEB,Mediterranean Center for Environment and Biodiversity(2010) European Project: 678589,H2020,H2020-SFS-2015-2,VIVALDI(2016) 2018 https://hal.science/hal-01898110 https://hal.science/hal-01898110/document https://hal.science/hal-01898110/file/Lorgeril-2018-NatCom-Immune.pdf https://doi.org/10.1038/s41467-018-06659-3 en eng HAL CCSD Nature Publishing Group info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-018-06659-3 info:eu-repo/grantAgreement//678589/EU/Preventing and mitigating farmed bivalve diseases/VIVALDI hal-01898110 https://hal.science/hal-01898110 https://hal.science/hal-01898110/document https://hal.science/hal-01898110/file/Lorgeril-2018-NatCom-Immune.pdf doi:10.1038/s41467-018-06659-3 info:eu-repo/semantics/OpenAccess ISSN: 2041-1723 EISSN: 2041-1723 Nature Communications https://hal.science/hal-01898110 Nature Communications, 2018, 9 (1), pp.4215. ⟨10.1038/s41467-018-06659-3⟩ https://www.nature.com/articles/s41467-018-06659-3 MU-VAR MORTALITY CRASSOSTREA-GIGAS HERPES-VIRUS TEMPERATURE FRANCE IRELAND ACL ANTIVIRAL RESPONSE OSTREID HERPESVIRUS-1 READ ALIGNMENT [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health [SDE.BE]Environmental Sciences/Biodiversity and Ecology info:eu-repo/semantics/article Journal articles 2018 ftinsu https://doi.org/10.1038/s41467-018-06659-3 2024-04-05T00:45:22Z International audience Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many diseases with a complex aetiology therefore remain misunderstood. By developing a holistic approach to tackle the complexity of interactions, we decipher the complex intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles of Crassostrea gigas, the main oyster species exploited worldwide. Using experimental infections reproducing the natural route of infection and combining thorough molecular analyses of oyster families with contrasted susceptibilities, we demonstrate that the disease is caused by multiple infection with an initial and necessary step of infection of oyster haemocytes by the Ostreid herpesvirus OsHV-1 µVar. Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. We propose the application of our integrative approach to decipher other multifactorial diseases that affect non-model species worldwide. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Institut national des sciences de l'Univers: HAL-INSU Nature Communications 9 1 |