Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury
International audience In the last decade, specific attention has been paid to total mercury (HgT) stable isotopic composition, especially in natural samples such as aquatic organisms, due to its potential to track the cycle of this toxic element in the environment. Here, we investigated Hg Compound...
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Online Access: | https://hal.science/hal-01495524 https://doi.org/10.1039/c5mt00286a |
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ftinsu:oai:HAL:hal-01495524v1 2023-12-17T10:26:28+01:00 Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury Perrot, Vincent Masbou, Jérémy Pastukhov, M.V. Epov, Vladimir Point, David Bérail, Sylvain Becker, Paul, R. Sonke, J.E. Amouroux, David Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM) Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) Géosciences Environnement Toulouse (GET) Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales Toulouse (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales Toulouse (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France-Centre National de la Recherche Scientifique (CNRS) Laboratory of Geochemical Mapping and Monitoring Hollings Marine Laboratory (NIST) National Institute of Standards and Technology Gaithersburg (NIST) 2016 https://hal.science/hal-01495524 https://doi.org/10.1039/c5mt00286a en eng HAL CCSD Royal Society of Chemistry info:eu-repo/semantics/altIdentifier/doi/10.1039/c5mt00286a hal-01495524 https://hal.science/hal-01495524 doi:10.1039/c5mt00286a ISSN: 1756-5901 EISSN: 1756-591X Metallomics https://hal.science/hal-01495524 Metallomics, 2016, 8 (2), pp.170--178. ⟨10.1039/c5mt00286a⟩ compound specific stable isotopic composition Methyl mercury Aquatic ecosystems nonhuman Fresh water lakes isotopic composition Isotope fractionation [CHIM]Chemical Sciences [CHIM.ANAL]Chemical Sciences/Analytical chemistry info:eu-repo/semantics/article Journal articles 2016 ftinsu https://doi.org/10.1039/c5mt00286a 2023-11-22T17:49:10Z International audience In the last decade, specific attention has been paid to total mercury (HgT) stable isotopic composition, especially in natural samples such as aquatic organisms, due to its potential to track the cycle of this toxic element in the environment. Here, we investigated Hg Compound Specific stable Isotopic Composition (CSIC) of natural inorganic Hg (iHg) and methylmercury (MMHg) in various tissues of aquatic mammals (Beluga whale from the Arctic marine environment and seals from the freshwater lake Baikal, Russia). In seals' organs the variation in mass dependent fractionation (MDF, δ202Hg) for total Hg was significantly correlated to the respective fraction of iHg and MMHg compounds, with MMHg being enriched by ∼3‰ in heavier isotopes relative to iHg. On the other hand, we observe insignificant variation in Hg mass independent isotope fractionation (MIF, Δ199Hg) among iHg and MMHg in all organs for the same mammal species and MMHg in prey items. MIF signatures suggest that both MMHg and iHg in aquatic mammals have the same origin (i.e., MMHg from food), and are representative of Hg photochemistry in the water column of the mammal ecosystem. MDF signatures of Hg compounds indicate that MMHg is demethylated in vivo before being stored in the muscle, and the iHg formed is stored in the liver, and to a lesser extent in the kidney, before excretion. Thus, Hg CSIC analysis in mammals can be a powerful tool for tracing the metabolic response to Hg exposure Article in Journal/Newspaper Arctic Beluga Beluga whale Beluga* Institut national des sciences de l'Univers: HAL-INSU Arctic Metallomics 8 2 170 178 |
institution |
Open Polar |
collection |
Institut national des sciences de l'Univers: HAL-INSU |
op_collection_id |
ftinsu |
language |
English |
topic |
compound specific stable isotopic composition Methyl mercury Aquatic ecosystems nonhuman Fresh water lakes isotopic composition Isotope fractionation [CHIM]Chemical Sciences [CHIM.ANAL]Chemical Sciences/Analytical chemistry |
spellingShingle |
compound specific stable isotopic composition Methyl mercury Aquatic ecosystems nonhuman Fresh water lakes isotopic composition Isotope fractionation [CHIM]Chemical Sciences [CHIM.ANAL]Chemical Sciences/Analytical chemistry Perrot, Vincent Masbou, Jérémy Pastukhov, M.V. Epov, Vladimir Point, David Bérail, Sylvain Becker, Paul, R. Sonke, J.E. Amouroux, David Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury |
topic_facet |
compound specific stable isotopic composition Methyl mercury Aquatic ecosystems nonhuman Fresh water lakes isotopic composition Isotope fractionation [CHIM]Chemical Sciences [CHIM.ANAL]Chemical Sciences/Analytical chemistry |
description |
International audience In the last decade, specific attention has been paid to total mercury (HgT) stable isotopic composition, especially in natural samples such as aquatic organisms, due to its potential to track the cycle of this toxic element in the environment. Here, we investigated Hg Compound Specific stable Isotopic Composition (CSIC) of natural inorganic Hg (iHg) and methylmercury (MMHg) in various tissues of aquatic mammals (Beluga whale from the Arctic marine environment and seals from the freshwater lake Baikal, Russia). In seals' organs the variation in mass dependent fractionation (MDF, δ202Hg) for total Hg was significantly correlated to the respective fraction of iHg and MMHg compounds, with MMHg being enriched by ∼3‰ in heavier isotopes relative to iHg. On the other hand, we observe insignificant variation in Hg mass independent isotope fractionation (MIF, Δ199Hg) among iHg and MMHg in all organs for the same mammal species and MMHg in prey items. MIF signatures suggest that both MMHg and iHg in aquatic mammals have the same origin (i.e., MMHg from food), and are representative of Hg photochemistry in the water column of the mammal ecosystem. MDF signatures of Hg compounds indicate that MMHg is demethylated in vivo before being stored in the muscle, and the iHg formed is stored in the liver, and to a lesser extent in the kidney, before excretion. Thus, Hg CSIC analysis in mammals can be a powerful tool for tracing the metabolic response to Hg exposure |
author2 |
Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM) Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) Géosciences Environnement Toulouse (GET) Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales Toulouse (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales Toulouse (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France-Centre National de la Recherche Scientifique (CNRS) Laboratory of Geochemical Mapping and Monitoring Hollings Marine Laboratory (NIST) National Institute of Standards and Technology Gaithersburg (NIST) |
format |
Article in Journal/Newspaper |
author |
Perrot, Vincent Masbou, Jérémy Pastukhov, M.V. Epov, Vladimir Point, David Bérail, Sylvain Becker, Paul, R. Sonke, J.E. Amouroux, David |
author_facet |
Perrot, Vincent Masbou, Jérémy Pastukhov, M.V. Epov, Vladimir Point, David Bérail, Sylvain Becker, Paul, R. Sonke, J.E. Amouroux, David |
author_sort |
Perrot, Vincent |
title |
Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury |
title_short |
Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury |
title_full |
Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury |
title_fullStr |
Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury |
title_full_unstemmed |
Natural Hg isotopic composition of different Hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury |
title_sort |
natural hg isotopic composition of different hg compounds in mammal tissues as a proxy for in vivo breakdown of toxic methylmercury |
publisher |
HAL CCSD |
publishDate |
2016 |
url |
https://hal.science/hal-01495524 https://doi.org/10.1039/c5mt00286a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Beluga Beluga whale Beluga* |
genre_facet |
Arctic Beluga Beluga whale Beluga* |
op_source |
ISSN: 1756-5901 EISSN: 1756-591X Metallomics https://hal.science/hal-01495524 Metallomics, 2016, 8 (2), pp.170--178. ⟨10.1039/c5mt00286a⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1039/c5mt00286a hal-01495524 https://hal.science/hal-01495524 doi:10.1039/c5mt00286a |
op_doi |
https://doi.org/10.1039/c5mt00286a |
container_title |
Metallomics |
container_volume |
8 |
container_issue |
2 |
container_start_page |
170 |
op_container_end_page |
178 |
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1785578191256027136 |