The Bromotyrosine Derivative Ianthelline Isolated from the Arctic Marine Sponge Stryphnus fortis Inhibits Marine Micro- and Macrobiofouling

• Published in: Marine Biotechnology
• Main Authors: Hanssen, Kine Ø., Cervin, Gunnar, Trepos, Rozenn, Petitbois, Julie, Haug, Tor, Hansen, Espen, Andersen, Jeanette H., Pavia, Henrik, Hellio, Claire, Svenson, Johan
• Other Authors: The Arctic University of Norway Tromsø, Norway (UiT), Göteborgs Universitet = University of Gothenburg (GU), School of Biological Sciences, University of Portsmouth, Marbio, University of Tromsø (UiT), Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Research Council of Norway Centre for Marine Chemical Ecology at the University of Gothenburg
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2014
• Subjects: Bromotyrosine; Marine natural product; Ianthelline; ACL; Sponge metabolite; Antifouling; [SDV]Life Sciences [q-bio]; [SDE]Environmental Sciences; [SDE.BE]Environmental Sciences/Biodiversity and Ecology; Arctic
• Online Access: https://hal.univ-brest.fr/hal-01104705; https://doi.org/10.1007/s10126-014-9583-y

International audience The inhibition of marine biofouling by the bromotyrosine derivative ianthelline, isolated from the Arctic marine sponge Stryphnus fortis, is described. All major stages of the fouling process are investigated. The effect of ianthelline on adhesion and growth of marine bacteria and microalgae is tested to investigate its influence on the initial microfouling process comparing with the known marine antifoulant barettin as a reference. Macrofouling is studied via barnacle (Balanus improvisus) settlement assays and blue mussel (Mytilus edulis) phenoloxidase inhibition. Ianthelline is shown to inhibit both marine micro-and macrofoulers with a pronounced effect on marine bacteria (minimum inhibitory concentration (MIC) values 0.1-10 mu g/mL) and barnacle larval settlement (IC50= 3.0 mu g/mL). Moderate effects are recorded on M. edulis (IC50= 45.2 mu g/mL) and microalgae, where growth is more affected than surface adhesion. The effect of ianthelline is also investigated against human pathogenic bacteria. Ianthelline displayed low micromolar MIC values against several bacterial strains, both Gram positive and Gram negative, down to 2.5 mu g/mL. In summary, the effect of ianthelline on 20 different representative marine antifouling organisms and seven human pathogenic bacterial strains is presented.