Hypolipidemic effect of camu-camu juice in rats
Objective: This study evaluated the potential hypolipidemic effect of camu-camu juice (Myrciaria dubia (Kunth) McVaugh) in dyslipidemic rats. Methods: Seventy-two adult male Wistar rats (Rattus norvegicus var. albinus Berkenhout) with an average weight of 200g were used. The experiment was divided i...
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ftinstnpamazon:oai:repositorio:1/16149 2023-05-15T18:05:30+02:00 Hypolipidemic effect of camu-camu juice in rats Efeito hipolipidêmico do suco de camu-camu em ratos Schwertz, Maíra Cássia Maia, Jeniffer Resende Patrocínio Sousa, Rita Fernandes Cássia P. de Aguiar, Jaime Paiva Lopes Yuyama, Lucia Kiyoko Ozaki Lima, Emerson Silva 2012 application/pdf https://repositorio.inpa.gov.br/handle/1/16149 https://doi.org/10.1590/S1415-52732012000100004 pt_BR por Revista de Nutrição Volume 25, Número 1, Pags. 35-44 https://repositorio.inpa.gov.br/handle/1/16149 doi:10.1590/S1415-52732012000100004 Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ CC-BY-NC-ND Animalsia Myrciaria Dubia Rattus Rattus Norvegicus Artigo 2012 ftinstnpamazon https://doi.org/10.1590/S1415-52732012000100004 2020-08-26T12:29:44Z Objective: This study evaluated the potential hypolipidemic effect of camu-camu juice (Myrciaria dubia (Kunth) McVaugh) in dyslipidemic rats. Methods: Seventy-two adult male Wistar rats (Rattus norvegicus var. albinus Berkenhout) with an average weight of 200g were used. The experiment was divided into two phases: induction of dyslipidemia and treatment. Dyslipidemia was induced by a high-fat diet (commercial feed plus 10.0% lard, 1.0% cholesterol and 0.1% cholic acid) given to the animals for 21 days. In the treatment phase, 40 dyslipidemic rats were randomly divided into five groups (n=8). Of these, three were subjected to different treatments with camu-camu juice: 0.4mL.kg-1, 4.0mL.kg-1 and 10mL.kg-1 for 14 days. The other two groups were kept as parameters: a basal group (normolipidemic) and a hyperlipidemic group receiving 10mL.kg-1 of quercetin (standard treatment). The potential hypolipidemic effect of camu-camu juice was assessed by the following measurements: plasma lipoproteins (triacylglycerol, total cholesterol, high density lipoprotein-cholesterol and low density lipoproteincholesterol), fecal and liver cholesterol, and measurements of feed intake and body weight. Results: All dosages of camu-camu juice were hypolipidemic, reducing triacylglycerol, total cholesterol, fecal cholesterol excretion and hepatic cholesterol. The best results were obtained by the 10 mL.kg-1 dosage of camu-camu juice. Rat body weight and food intake did not vary significantly during the treatment. Conclusion Camu-camu juice has a hypolipidemic effect in dyslipidemic rats. These results can be used as reference for future studies on this Amazonian fruit. Article in Journal/Newspaper Rattus rattus Repositório do INPA Revista de Nutrição 25 1 35 44 |
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Open Polar |
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Repositório do INPA |
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ftinstnpamazon |
language |
Portuguese |
topic |
Animalsia Myrciaria Dubia Rattus Rattus Norvegicus |
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Animalsia Myrciaria Dubia Rattus Rattus Norvegicus Schwertz, Maíra Cássia Maia, Jeniffer Resende Patrocínio Sousa, Rita Fernandes Cássia P. de Aguiar, Jaime Paiva Lopes Yuyama, Lucia Kiyoko Ozaki Lima, Emerson Silva Hypolipidemic effect of camu-camu juice in rats |
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Animalsia Myrciaria Dubia Rattus Rattus Norvegicus |
description |
Objective: This study evaluated the potential hypolipidemic effect of camu-camu juice (Myrciaria dubia (Kunth) McVaugh) in dyslipidemic rats. Methods: Seventy-two adult male Wistar rats (Rattus norvegicus var. albinus Berkenhout) with an average weight of 200g were used. The experiment was divided into two phases: induction of dyslipidemia and treatment. Dyslipidemia was induced by a high-fat diet (commercial feed plus 10.0% lard, 1.0% cholesterol and 0.1% cholic acid) given to the animals for 21 days. In the treatment phase, 40 dyslipidemic rats were randomly divided into five groups (n=8). Of these, three were subjected to different treatments with camu-camu juice: 0.4mL.kg-1, 4.0mL.kg-1 and 10mL.kg-1 for 14 days. The other two groups were kept as parameters: a basal group (normolipidemic) and a hyperlipidemic group receiving 10mL.kg-1 of quercetin (standard treatment). The potential hypolipidemic effect of camu-camu juice was assessed by the following measurements: plasma lipoproteins (triacylglycerol, total cholesterol, high density lipoprotein-cholesterol and low density lipoproteincholesterol), fecal and liver cholesterol, and measurements of feed intake and body weight. Results: All dosages of camu-camu juice were hypolipidemic, reducing triacylglycerol, total cholesterol, fecal cholesterol excretion and hepatic cholesterol. The best results were obtained by the 10 mL.kg-1 dosage of camu-camu juice. Rat body weight and food intake did not vary significantly during the treatment. Conclusion Camu-camu juice has a hypolipidemic effect in dyslipidemic rats. These results can be used as reference for future studies on this Amazonian fruit. |
format |
Article in Journal/Newspaper |
author |
Schwertz, Maíra Cássia Maia, Jeniffer Resende Patrocínio Sousa, Rita Fernandes Cássia P. de Aguiar, Jaime Paiva Lopes Yuyama, Lucia Kiyoko Ozaki Lima, Emerson Silva |
author_facet |
Schwertz, Maíra Cássia Maia, Jeniffer Resende Patrocínio Sousa, Rita Fernandes Cássia P. de Aguiar, Jaime Paiva Lopes Yuyama, Lucia Kiyoko Ozaki Lima, Emerson Silva |
author_sort |
Schwertz, Maíra Cássia |
title |
Hypolipidemic effect of camu-camu juice in rats |
title_short |
Hypolipidemic effect of camu-camu juice in rats |
title_full |
Hypolipidemic effect of camu-camu juice in rats |
title_fullStr |
Hypolipidemic effect of camu-camu juice in rats |
title_full_unstemmed |
Hypolipidemic effect of camu-camu juice in rats |
title_sort |
hypolipidemic effect of camu-camu juice in rats |
publisher |
Revista de Nutrição |
publishDate |
2012 |
url |
https://repositorio.inpa.gov.br/handle/1/16149 https://doi.org/10.1590/S1415-52732012000100004 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
Volume 25, Número 1, Pags. 35-44 https://repositorio.inpa.gov.br/handle/1/16149 doi:10.1590/S1415-52732012000100004 |
op_rights |
Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1590/S1415-52732012000100004 |
container_title |
Revista de Nutrição |
container_volume |
25 |
container_issue |
1 |
container_start_page |
35 |
op_container_end_page |
44 |
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1766176970555523072 |