Hypolipidemic effect of diet supplementation with cocona (solanum sessiliforum dunal) four in hypercholesterolemic rats.

Studies with fruit and vegetables rich in dietary fber have shown lowering effects on the blood concentrations of total cholesterol (TC), acting preventively against hypercholesterolemia. The aim of this study was to analyze the chemical composition of cocona and evaluate the effect of the consumpti...

Full description

Bibliographic Details
Published in:Revista Brasileira de Plantas Medicinais
Main Authors: Maia, Jeniffer Resende Patrocínio, Schwertz, Maíra Cássia, Sousa, R. F S, Aguiar, Jaime Paiva Lopes, Lima, Emerson Silva
Format: Article in Journal/Newspaper
Language:Portuguese
Published: Revista Brasileira de Plantas Medicinais 2015
Subjects:
Antilipemic Agent
Cellulose
Cholesterol
Low Density Lipoprotein Cholesterol
Pectin
Animals Model
Chemical Composition
Controlled Study
Diet Supplementation
Dietary Fiber
Flour
Fruit
Hypercholesterolemia
Nonhuman
Rat
Solanum
Solanum Sessiliflorum
Animalsia
Rattus
Rattus Norvegicus
Rattus rattus
Online Access:https://repositorio.inpa.gov.br/handle/1/15933
https://doi.org/10.1590/1983-084X/11_163
Description
Summary:Studies with fruit and vegetables rich in dietary fber have shown lowering effects on the blood concentrations of total cholesterol (TC), acting preventively against hypercholesterolemia. The aim of this study was to analyze the chemical composition of cocona and evaluate the effect of the consumption of cocona four on lipemia of Wistar rats with hypercholesterolemia. Eight animals were used for each treatment, in 7 groups: control; 3 experimental groups with 5%, 25% and 50% of the recommended fber (AIN-93) from cocona four; 3 groups per feeding with pectin and cellulose as source of dietary fber, in the same proportions of the experimental groups. At the end of the assay, we verifed that there were not signifcant variations in the consumption of the animals and the body weight during the experiment. Treatments with cocna four were responsible for reducing the concentrations of total cholesterol (-21.6%), LDL-c (-56.8%), increasing the excretion of fecal cholesterol (+116%) and lowering the liver cholesterol (-32.1%). None of the treatments signifcantly altered the triglyceride concentrations. Treatments using pectin and cellulose show results similar to cocona. The observed results can be used in further studies aimed at the biotechnological exploitation of this fruit. © 2015, Instituto de Biociencias. All rights reserved.

Similar Items