Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16(th)-19(th) Century.
International audience Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient su...
Published in: | PLoS ONE |
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Main Authors: | , , , , , , , , , , , |
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Format: | Article in Journal/Newspaper |
Language: | English |
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HAL CCSD
2014
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Online Access: | https://hal.science/hal-00967590 https://hal.science/hal-00967590/document https://hal.science/hal-00967590/file/2014_Dabernat_et_al._Plos_One.pdf https://doi.org/10.1371/journal.pone.0089877 |
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INRAP: HAL (Institut national de recherches archéologiques préventives) |
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English |
topic |
[SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology [SDE]Environmental Sciences |
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[SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology [SDE]Environmental Sciences Dabernat, Henri Thèves, Catherine Bouakaze, Caroline Nikolaeva, Dariya Keyser, Christine Mokrousov, Igor Geraut, Annie Duchesne, Sylvie Gérard, Patrice Alekseev, Anatoly N Crubézy, Eric Ludes, Bertrand Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16(th)-19(th) Century. |
topic_facet |
[SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology [SDE]Environmental Sciences |
description |
International audience Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient subjects inhumed in Yakutia (Eastern Siberia) during a tuberculosis outbreak, dating from the 16th-19th century. For a long time, Yakut populations had remained isolated from European populations, and it was not until the beginning of the 17th century that first contacts were made with European settlers. Subsequently, tuberculosis spread throughout Yakutia, and the evolution of tuberculosis frequencies can be tracked until the 19th century. This study took a multidisciplinary approach, examining historical and paleo-epidemiological data to understand the impact of tuberculosis on ancient Yakut population. In addition, molecular identification of the ancient tuberculosis strain was realized to elucidate the natural history and host-pathogen co-evolution of human tuberculosis that was present in this population. This was achieved by the molecular detection of the IS6110 sequence and SNP genotyping by the SNaPshot technique. Results demonstrated that the strain belongs to cluster PGG2-SCG-5, evocating a European origin. Our study suggests that the Yakut population may have been shaped by selection pressures, exerted by several illnesses, including tuberculosis, over several centuries. This confirms the validity and necessity of using a multidisciplinary approach to understand the natural history of Mycobacterium tuberculosis infection and disease. |
author2 |
Anthropologie Moléculaire et Imagerie de Synthèse (AMIS) Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS) Laboratoire d'Anthropologie Moléculaire, Institut de Médecine Légale, Strasbourg, France (IML) Université Louis Pasteur - Strasbourg I Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) Institut Pasteur de Saint-Pétersbourg Réseau International des Instituts Pasteur (RIIP) Institut de Médecine Légale Strasbourg Siberian Branch of the Russian Academy of Sciences (SB RAS) Laboratoire d'Anthropobiologie (LA) École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J) Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS) Institute of Legal Medicine Université Paris Descartes - Paris 5 (UPD5) |
format |
Article in Journal/Newspaper |
author |
Dabernat, Henri Thèves, Catherine Bouakaze, Caroline Nikolaeva, Dariya Keyser, Christine Mokrousov, Igor Geraut, Annie Duchesne, Sylvie Gérard, Patrice Alekseev, Anatoly N Crubézy, Eric Ludes, Bertrand |
author_facet |
Dabernat, Henri Thèves, Catherine Bouakaze, Caroline Nikolaeva, Dariya Keyser, Christine Mokrousov, Igor Geraut, Annie Duchesne, Sylvie Gérard, Patrice Alekseev, Anatoly N Crubézy, Eric Ludes, Bertrand |
author_sort |
Dabernat, Henri |
title |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16(th)-19(th) Century. |
title_short |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16(th)-19(th) Century. |
title_full |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16(th)-19(th) Century. |
title_fullStr |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16(th)-19(th) Century. |
title_full_unstemmed |
Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16(th)-19(th) Century. |
title_sort |
tuberculosis epidemiology and selection in an autochthonous siberian population from the 16(th)-19(th) century. |
publisher |
HAL CCSD |
publishDate |
2014 |
url |
https://hal.science/hal-00967590 https://hal.science/hal-00967590/document https://hal.science/hal-00967590/file/2014_Dabernat_et_al._Plos_One.pdf https://doi.org/10.1371/journal.pone.0089877 |
genre |
Yakut Yakutia Siberia |
genre_facet |
Yakut Yakutia Siberia |
op_source |
ISSN: 1932-6203 EISSN: 1932-6203 PLoS ONE https://hal.science/hal-00967590 PLoS ONE, 2014, 9 (2), pp.e89877. ⟨10.1371/journal.pone.0089877⟩ |
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op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0089877 |
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PLoS ONE |
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e89877 |
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spelling |
ftinstitutnrap:oai:HAL:hal-00967590v1 2024-04-14T08:20:47+00:00 Tuberculosis Epidemiology and Selection in an Autochthonous Siberian Population from the 16(th)-19(th) Century. Dabernat, Henri Thèves, Catherine Bouakaze, Caroline Nikolaeva, Dariya Keyser, Christine Mokrousov, Igor Geraut, Annie Duchesne, Sylvie Gérard, Patrice Alekseev, Anatoly N Crubézy, Eric Ludes, Bertrand Anthropologie Moléculaire et Imagerie de Synthèse (AMIS) Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS) Laboratoire d'Anthropologie Moléculaire, Institut de Médecine Légale, Strasbourg, France (IML) Université Louis Pasteur - Strasbourg I Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) Institut Pasteur de Saint-Pétersbourg Réseau International des Instituts Pasteur (RIIP) Institut de Médecine Légale Strasbourg Siberian Branch of the Russian Academy of Sciences (SB RAS) Laboratoire d'Anthropobiologie (LA) École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J) Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS) Institute of Legal Medicine Université Paris Descartes - Paris 5 (UPD5) 2014-02-26 https://hal.science/hal-00967590 https://hal.science/hal-00967590/document https://hal.science/hal-00967590/file/2014_Dabernat_et_al._Plos_One.pdf https://doi.org/10.1371/journal.pone.0089877 en eng HAL CCSD Public Library of Science info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0089877 info:eu-repo/semantics/altIdentifier/pmid/24587092 hal-00967590 https://hal.science/hal-00967590 https://hal.science/hal-00967590/document https://hal.science/hal-00967590/file/2014_Dabernat_et_al._Plos_One.pdf doi:10.1371/journal.pone.0089877 PUBMED: 24587092 info:eu-repo/semantics/OpenAccess ISSN: 1932-6203 EISSN: 1932-6203 PLoS ONE https://hal.science/hal-00967590 PLoS ONE, 2014, 9 (2), pp.e89877. ⟨10.1371/journal.pone.0089877⟩ [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology [SDE]Environmental Sciences info:eu-repo/semantics/article Journal articles 2014 ftinstitutnrap https://doi.org/10.1371/journal.pone.0089877 2024-03-21T16:27:49Z International audience Tuberculosis is one of most ancient diseases affecting human populations. Although numerous studies have tried to detect pathogenic DNA in ancient skeletons, the successful identification of ancient tuberculosis strains remains rare. Here, we describe a study of 140 ancient subjects inhumed in Yakutia (Eastern Siberia) during a tuberculosis outbreak, dating from the 16th-19th century. For a long time, Yakut populations had remained isolated from European populations, and it was not until the beginning of the 17th century that first contacts were made with European settlers. Subsequently, tuberculosis spread throughout Yakutia, and the evolution of tuberculosis frequencies can be tracked until the 19th century. This study took a multidisciplinary approach, examining historical and paleo-epidemiological data to understand the impact of tuberculosis on ancient Yakut population. In addition, molecular identification of the ancient tuberculosis strain was realized to elucidate the natural history and host-pathogen co-evolution of human tuberculosis that was present in this population. This was achieved by the molecular detection of the IS6110 sequence and SNP genotyping by the SNaPshot technique. Results demonstrated that the strain belongs to cluster PGG2-SCG-5, evocating a European origin. Our study suggests that the Yakut population may have been shaped by selection pressures, exerted by several illnesses, including tuberculosis, over several centuries. This confirms the validity and necessity of using a multidisciplinary approach to understand the natural history of Mycobacterium tuberculosis infection and disease. Article in Journal/Newspaper Yakut Yakutia Siberia INRAP: HAL (Institut national de recherches archéologiques préventives) PLoS ONE 9 2 e89877 |