Ambient air pollution and lipid profile: systematic review and meta-analysis
Ambient air pollution (AAP) is recognized a cardiovascular risk factor and lipid profile dysregulation seems to be one of the potential mediators involved. However, results from epidemiologic research on the association between exposure to AAP and altered lipid profile have been inconsistent. This s...
Published in: | Environmental Pollution |
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Language: | English |
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Elsevier
2020
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Online Access: | http://hdl.handle.net/10400.18/6469 https://doi.org/10.1016/j.envpol.2019.113036 |
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ftinssaudelisboa:oai:repositorio.insa.pt:10400.18/6469 |
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National Health Institute, Portugal: Repositório Científico |
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ftinssaudelisboa |
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English |
topic |
Ambient Air Pollution Lipid Profile Systematic Review Meta-analysis Estados de Saúde e de Doença |
spellingShingle |
Ambient Air Pollution Lipid Profile Systematic Review Meta-analysis Estados de Saúde e de Doença Gaio, Vânia Roquette, Rita Dias, Carlos Matias Nunes, Baltazar Ambient air pollution and lipid profile: systematic review and meta-analysis |
topic_facet |
Ambient Air Pollution Lipid Profile Systematic Review Meta-analysis Estados de Saúde e de Doença |
description |
Ambient air pollution (AAP) is recognized a cardiovascular risk factor and lipid profile dysregulation seems to be one of the potential mediators involved. However, results from epidemiologic research on the association between exposure to AAP and altered lipid profile have been inconsistent. This study aims to systematically review and meta-analyse epidemiologic evidence on the association between exposure to ambient air pollutants (particulate matter, nitrogen oxides, sulphur dioxide, ozone, carbon monoxide, back carbon) and lipid profile parameters (Total cholesterol; High-Density Lipoprotein Cholesterol; Low-Density Lipoprotein Cholesterol; TG-Triglycerides) or dyslipidaemia. Systematic electronic literature search was performed in PubMed, Web of Science and Scopus databases (last search on 24th May 2019) using keywords related to the exposure (ambient air pollutants) and to the outcomes (lipid profile parameters/dyslipidaemia). Qualitative and quantitative information of the studies were extracted and fixed or random-effects models were used to obtain a pooled effect estimate per each pollutant/outcome combination. 22 studies were qualitatively analysed and, from those, 3 studies were quantitatively analysed. Particulate matters were the most studied pollutants and a considerable heterogeneity in air pollution assessment methods and outcomes definitions was detected. Age, obesity related measures, tobacco consumption, sex and socioeconomic factors were the most frequent considered variables for confounding adjustment in the models. In a long-term exposure scenario, we found a 3.14% (1.36%-4.95%) increase in TG levels per 10 μg/m3 PM10 increment and a 4.24% (1.37%-7.19%) increase in TG levels per 10 μg/m3 NO2 increment. No significant associations were detected for the remaining pollutant/outcome combinations. Despite the few studies included in the meta-analysis, our study suggests some epidemiologic evidence supporting the association between PM10 and NO2 exposures and increased TG levels. Due to the very low level of evidence, more studies are needed to clarify the role of lipid profile dysregulation as a mediator on the AAP adverse cardiovascular effects. Highlights: Ambient air pollution (AAP) is recognized as a risk factor for cardiovascular diseases; First systematic review and meta-analysis on the association between ambient air pollutants exposure and lipid profile; Some epidemiologic evidence supporting the association between PM10 and NO2 exposures and increased Triglycerides levels; More studies are needed to clarify the association between ambient air pollutants exposure and lipid profile. The authors are grateful to all the professionals and participants involved in the INSEF. INSEF was developed as part of the Predefined project financed under the Public Health Initiatives Program, ‘‘Improvement of epidemiological health information to support public health decision and management in Portugal. Towards reduced inequalities, improved health, and bilateral cooperation”, with a 1.500.000V Grant from Iceland, Liechtenstein and Norway from EEA Grants and the Portuguese Government. The present study was also funded by the Portuguese Foundation for Science and Technology (FCT) (PhD Scholarship Reference: SFRH/BD/129426/2017). info:eu-repo/semantics/publishedVersion |
format |
Article in Journal/Newspaper |
author |
Gaio, Vânia Roquette, Rita Dias, Carlos Matias Nunes, Baltazar |
author_facet |
Gaio, Vânia Roquette, Rita Dias, Carlos Matias Nunes, Baltazar |
author_sort |
Gaio, Vânia |
title |
Ambient air pollution and lipid profile: systematic review and meta-analysis |
title_short |
Ambient air pollution and lipid profile: systematic review and meta-analysis |
title_full |
Ambient air pollution and lipid profile: systematic review and meta-analysis |
title_fullStr |
Ambient air pollution and lipid profile: systematic review and meta-analysis |
title_full_unstemmed |
Ambient air pollution and lipid profile: systematic review and meta-analysis |
title_sort |
ambient air pollution and lipid profile: systematic review and meta-analysis |
publisher |
Elsevier |
publishDate |
2020 |
url |
http://hdl.handle.net/10400.18/6469 https://doi.org/10.1016/j.envpol.2019.113036 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://www.sciencedirect.com/science/article/pii/S0269749119314654?via%3Dihub Environ Pollut. 2019 Nov;254(Pt B):113036. doi:10.1016/j.envpol.2019.113036. Epub 2019 Aug 9 0269-7491 http://hdl.handle.net/10400.18/6469 doi:10.1016/j.envpol.2019.113036 |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1016/j.envpol.2019.113036 |
container_title |
Environmental Pollution |
container_volume |
254 |
container_start_page |
113036 |
_version_ |
1766043733328920576 |
spelling |
ftinssaudelisboa:oai:repositorio.insa.pt:10400.18/6469 2023-05-15T16:53:13+02:00 Ambient air pollution and lipid profile: systematic review and meta-analysis Gaio, Vânia Roquette, Rita Dias, Carlos Matias Nunes, Baltazar 2020-04-21T15:46:31Z http://hdl.handle.net/10400.18/6469 https://doi.org/10.1016/j.envpol.2019.113036 eng eng Elsevier https://www.sciencedirect.com/science/article/pii/S0269749119314654?via%3Dihub Environ Pollut. 2019 Nov;254(Pt B):113036. doi:10.1016/j.envpol.2019.113036. Epub 2019 Aug 9 0269-7491 http://hdl.handle.net/10400.18/6469 doi:10.1016/j.envpol.2019.113036 openAccess Ambient Air Pollution Lipid Profile Systematic Review Meta-analysis Estados de Saúde e de Doença article 2020 ftinssaudelisboa https://doi.org/10.1016/j.envpol.2019.113036 2021-10-06T00:01:28Z Ambient air pollution (AAP) is recognized a cardiovascular risk factor and lipid profile dysregulation seems to be one of the potential mediators involved. However, results from epidemiologic research on the association between exposure to AAP and altered lipid profile have been inconsistent. This study aims to systematically review and meta-analyse epidemiologic evidence on the association between exposure to ambient air pollutants (particulate matter, nitrogen oxides, sulphur dioxide, ozone, carbon monoxide, back carbon) and lipid profile parameters (Total cholesterol; High-Density Lipoprotein Cholesterol; Low-Density Lipoprotein Cholesterol; TG-Triglycerides) or dyslipidaemia. Systematic electronic literature search was performed in PubMed, Web of Science and Scopus databases (last search on 24th May 2019) using keywords related to the exposure (ambient air pollutants) and to the outcomes (lipid profile parameters/dyslipidaemia). Qualitative and quantitative information of the studies were extracted and fixed or random-effects models were used to obtain a pooled effect estimate per each pollutant/outcome combination. 22 studies were qualitatively analysed and, from those, 3 studies were quantitatively analysed. Particulate matters were the most studied pollutants and a considerable heterogeneity in air pollution assessment methods and outcomes definitions was detected. Age, obesity related measures, tobacco consumption, sex and socioeconomic factors were the most frequent considered variables for confounding adjustment in the models. In a long-term exposure scenario, we found a 3.14% (1.36%-4.95%) increase in TG levels per 10 μg/m3 PM10 increment and a 4.24% (1.37%-7.19%) increase in TG levels per 10 μg/m3 NO2 increment. No significant associations were detected for the remaining pollutant/outcome combinations. Despite the few studies included in the meta-analysis, our study suggests some epidemiologic evidence supporting the association between PM10 and NO2 exposures and increased TG levels. Due to the very low level of evidence, more studies are needed to clarify the role of lipid profile dysregulation as a mediator on the AAP adverse cardiovascular effects. Highlights: Ambient air pollution (AAP) is recognized as a risk factor for cardiovascular diseases; First systematic review and meta-analysis on the association between ambient air pollutants exposure and lipid profile; Some epidemiologic evidence supporting the association between PM10 and NO2 exposures and increased Triglycerides levels; More studies are needed to clarify the association between ambient air pollutants exposure and lipid profile. The authors are grateful to all the professionals and participants involved in the INSEF. INSEF was developed as part of the Predefined project financed under the Public Health Initiatives Program, ‘‘Improvement of epidemiological health information to support public health decision and management in Portugal. Towards reduced inequalities, improved health, and bilateral cooperation”, with a 1.500.000V Grant from Iceland, Liechtenstein and Norway from EEA Grants and the Portuguese Government. The present study was also funded by the Portuguese Foundation for Science and Technology (FCT) (PhD Scholarship Reference: SFRH/BD/129426/2017). info:eu-repo/semantics/publishedVersion Article in Journal/Newspaper Iceland National Health Institute, Portugal: Repositório Científico Norway Environmental Pollution 254 113036 |