Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway
International audience Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seropre...
Published in: | Medical Microbiology and Immunology |
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ftinserm:oai:HAL:hal-03556760v1 2024-04-21T08:08:34+00:00 Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway: The Tromsø study Olsøy, Irene Beate Henriksen, Stian Weissbach, Fabian Larsen, Marthe Borgen, Karoline Abravanel, Florence Kamar, Nassim Paulssen, Eyvind Hirsch, Hans Rinaldo, Christine Hanssen University Hospital of North Norway Tromsø (UNN) The Arctic University of Norway Tromsø, Norway (UiT) Université de Bâle = University of Basel = Basel Universität (Unibas) Centre de Physiopathologie Toulouse Purpan (CPTP) Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) 2019-12 https://ut3-toulouseinp.hal.science/hal-03556760 https://doi.org/10.1007/s00430-019-00599-5 en eng HAL CCSD Springer Verlag info:eu-repo/semantics/altIdentifier/doi/10.1007/s00430-019-00599-5 info:eu-repo/semantics/altIdentifier/pmid/30903372 hal-03556760 https://ut3-toulouseinp.hal.science/hal-03556760 doi:10.1007/s00430-019-00599-5 PUBMED: 30903372 ISSN: 0300-8584 EISSN: 1432-1831 Medical Microbiology and Immunology https://ut3-toulouseinp.hal.science/hal-03556760 Medical Microbiology and Immunology, 2019, 208 (6), pp.715-725. ⟨10.1007/s00430-019-00599-5⟩ Enzyme-linked immunosorbent assay Hepatitis Hepatitis E virus Immunoglobulin G Seroepidemiologic study MESH: Adult MESH: Aged MESH: Middle Aged MESH: Norway / epidemiology MESH: Risk Factors MESH: Seroepidemiologic Studies MESH: Enzyme-Linked Immunosorbent Assay MESH: Female MESH: Hepatitis Antibodies / blood* MESH: Hepatitis E / epidemiology* MESH: Hepatitis E virus / immunology* MESH: Humans MESH: Immunoglobulin G / blood MESH: Male [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases info:eu-repo/semantics/article Journal articles 2019 ftinserm https://doi.org/10.1007/s00430-019-00599-5 2024-03-28T01:07:17Z International audience Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seroprevalence in Northern Norway. A total of 1800 serum samples from 900 women and 900 men, age 40-79 years, were randomly selected from the 21,083 participants in the 7th Tromsø Study, representing the 32,591 inhabitants of the Tromsø municipality that were ≥ 40 years. All samples were analyzed by ELISA-1 (recomWell HEV IgG). Samples testing positive or borderline, as well as a 1.5-fold excess of negative samples, were retested by ELISA-2 (DiaPro HEV IgG). If still borderline or a result discordant from ELISA-1, the sample was retested by ELISA-3 (Wantai HEV IgG) and strip-immunoassay (recomLine HEV IgG). Anti-HEV IgG was detected in 205 individuals (11.4%), yielding an estimated seroprevalence of 10.4% in the age-matched population of Tromsø. Using logistic regression analysis followed by multivariable backward elimination analysis, increasing age (OR 1.036 per year; p < 0.001) and higher education (OR 2.167; p < 0.001) were found as potential risk factors, whereas travel abroad or eating of red meat were not. Our results indicate that HEV-infection is common in Northern Norway and suggest that HEV testing should be included in the evaluation of elevated liver enzymes. Article in Journal/Newspaper Northern Norway Tromsø Inserm: HAL (Institut national de la santé et de la recherche médicale) Medical Microbiology and Immunology 208 6 715 725 |
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Inserm: HAL (Institut national de la santé et de la recherche médicale) |
op_collection_id |
ftinserm |
language |
English |
topic |
Enzyme-linked immunosorbent assay Hepatitis Hepatitis E virus Immunoglobulin G Seroepidemiologic study MESH: Adult MESH: Aged MESH: Middle Aged MESH: Norway / epidemiology MESH: Risk Factors MESH: Seroepidemiologic Studies MESH: Enzyme-Linked Immunosorbent Assay MESH: Female MESH: Hepatitis Antibodies / blood* MESH: Hepatitis E / epidemiology* MESH: Hepatitis E virus / immunology* MESH: Humans MESH: Immunoglobulin G / blood MESH: Male [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
spellingShingle |
Enzyme-linked immunosorbent assay Hepatitis Hepatitis E virus Immunoglobulin G Seroepidemiologic study MESH: Adult MESH: Aged MESH: Middle Aged MESH: Norway / epidemiology MESH: Risk Factors MESH: Seroepidemiologic Studies MESH: Enzyme-Linked Immunosorbent Assay MESH: Female MESH: Hepatitis Antibodies / blood* MESH: Hepatitis E / epidemiology* MESH: Hepatitis E virus / immunology* MESH: Humans MESH: Immunoglobulin G / blood MESH: Male [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Olsøy, Irene Beate Henriksen, Stian Weissbach, Fabian Larsen, Marthe Borgen, Karoline Abravanel, Florence Kamar, Nassim Paulssen, Eyvind Hirsch, Hans Rinaldo, Christine Hanssen Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway |
topic_facet |
Enzyme-linked immunosorbent assay Hepatitis Hepatitis E virus Immunoglobulin G Seroepidemiologic study MESH: Adult MESH: Aged MESH: Middle Aged MESH: Norway / epidemiology MESH: Risk Factors MESH: Seroepidemiologic Studies MESH: Enzyme-Linked Immunosorbent Assay MESH: Female MESH: Hepatitis Antibodies / blood* MESH: Hepatitis E / epidemiology* MESH: Hepatitis E virus / immunology* MESH: Humans MESH: Immunoglobulin G / blood MESH: Male [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
description |
International audience Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seroprevalence in Northern Norway. A total of 1800 serum samples from 900 women and 900 men, age 40-79 years, were randomly selected from the 21,083 participants in the 7th Tromsø Study, representing the 32,591 inhabitants of the Tromsø municipality that were ≥ 40 years. All samples were analyzed by ELISA-1 (recomWell HEV IgG). Samples testing positive or borderline, as well as a 1.5-fold excess of negative samples, were retested by ELISA-2 (DiaPro HEV IgG). If still borderline or a result discordant from ELISA-1, the sample was retested by ELISA-3 (Wantai HEV IgG) and strip-immunoassay (recomLine HEV IgG). Anti-HEV IgG was detected in 205 individuals (11.4%), yielding an estimated seroprevalence of 10.4% in the age-matched population of Tromsø. Using logistic regression analysis followed by multivariable backward elimination analysis, increasing age (OR 1.036 per year; p < 0.001) and higher education (OR 2.167; p < 0.001) were found as potential risk factors, whereas travel abroad or eating of red meat were not. Our results indicate that HEV-infection is common in Northern Norway and suggest that HEV testing should be included in the evaluation of elevated liver enzymes. |
author2 |
University Hospital of North Norway Tromsø (UNN) The Arctic University of Norway Tromsø, Norway (UiT) Université de Bâle = University of Basel = Basel Universität (Unibas) Centre de Physiopathologie Toulouse Purpan (CPTP) Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
Olsøy, Irene Beate Henriksen, Stian Weissbach, Fabian Larsen, Marthe Borgen, Karoline Abravanel, Florence Kamar, Nassim Paulssen, Eyvind Hirsch, Hans Rinaldo, Christine Hanssen |
author_facet |
Olsøy, Irene Beate Henriksen, Stian Weissbach, Fabian Larsen, Marthe Borgen, Karoline Abravanel, Florence Kamar, Nassim Paulssen, Eyvind Hirsch, Hans Rinaldo, Christine Hanssen |
author_sort |
Olsøy, Irene Beate |
title |
Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway |
title_short |
Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway |
title_full |
Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway |
title_fullStr |
Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway |
title_full_unstemmed |
Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway |
title_sort |
seroprevalence of hepatitis e virus (hev) in a general adult population in northern norway |
publisher |
HAL CCSD |
publishDate |
2019 |
url |
https://ut3-toulouseinp.hal.science/hal-03556760 https://doi.org/10.1007/s00430-019-00599-5 |
genre |
Northern Norway Tromsø |
genre_facet |
Northern Norway Tromsø |
op_source |
ISSN: 0300-8584 EISSN: 1432-1831 Medical Microbiology and Immunology https://ut3-toulouseinp.hal.science/hal-03556760 Medical Microbiology and Immunology, 2019, 208 (6), pp.715-725. ⟨10.1007/s00430-019-00599-5⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00430-019-00599-5 info:eu-repo/semantics/altIdentifier/pmid/30903372 hal-03556760 https://ut3-toulouseinp.hal.science/hal-03556760 doi:10.1007/s00430-019-00599-5 PUBMED: 30903372 |
op_doi |
https://doi.org/10.1007/s00430-019-00599-5 |
container_title |
Medical Microbiology and Immunology |
container_volume |
208 |
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6 |
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715 |
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725 |
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