Human leptospirosis in Seychelles: A prospective study confirms the heavy burden of the disease but suggests that rats are not the main reservoir

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Biscornet, Leon, Dellagi, Koussay, Pagès, Frédéric, Bibi, Jastin, de Comarmond, Jeanine, Mélade, Julien, Govinden, Graham, Tirant, Maria, Gomard, Yann, Guernier, Vanina, Lagadec, Erwan, Mélanie, Jimmy, Rocamora, Gérard, Le Minter, Gildas, Jaubert, Julien, Mavingui, Patrick, Tortosa, Pablo
• Other Authors: Seychelles Public Health Laboratory, Ministry of Health Mozambique, Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien (CRVOI), Université de La Réunion (UR), Cyclotron Réunion Océan Indien (CYROI), Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Regional Office of the French Institute for Public Health Surveillance, Institut de Veille Sanitaire (INVS), Ministry of health of Seychelles, Ministry of agriculture and fisheries, Université des Seychelles, Groupe Hospitalier Sud Réunion (GHSR)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2017
• Subjects: Leptospira interrogans; Seychelles; Leptospirosis; Leptospira; Bacterial pathogens; Infectious disease epidemiology; Islands; Polymerase chain reaction; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; Rattus rattus
• Online Access: https://hal.univ-reunion.fr/hal-01592503; https://hal.univ-reunion.fr/hal-01592503/document; https://hal.univ-reunion.fr/hal-01592503/file/journal.pntd.0005831.pdf; https://doi.org/10.1371/journal.pntd.0005831

International audience Background: Leptospirosis is a bacterial zoonosis caused by pathogenic Leptospira for which rats are considered as the main reservoir. Disease incidence is higher in tropical countries, especially in insular ecosystems. Our objectives were to determine the current burden of le...