Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses
cited By 0 International audience One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV...
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Online Access: | https://hal.science/hal-01534743 https://hal.science/hal-01534743/document https://hal.science/hal-01534743/file/Insight%20into%20the%20global.pdf https://doi.org/10.1038/s41598-017-02206-0 |
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ftinserm:oai:HAL:hal-01534743v1 2024-09-15T18:32:03+00:00 Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses Ghawar, Wissem Pascalis, Hervé Bettaieb, Jihéne Mélade, Julien Gharbi, Adel Snoussi, Mohamed Ali Laouini, Dhafer Goodman, Steven M. Salah, Afif Ben Dellagi, Koussay Université de Tunis El Manar (UTM) Institut Pasteur de Tunis Réseau International des Instituts Pasteur (RIIP) Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien (CRVOI) Université de La Réunion (UR) Processus Infectieux en Milieu Insulaire Tropical (PIMIT) Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS) Association Vahatra Antananarivo, Madagascar Field Museum of Natural History Chicago, USA Cyclotron Réunion Océan Indien (CYROI) Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion) Laboratoire de Transmission, Contrôle et Immunobiologie des Infections - Laboratory of Transmission, Control and Immunobiology of Infection (LR11IPT02) Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) 2017 https://hal.science/hal-01534743 https://hal.science/hal-01534743/document https://hal.science/hal-01534743/file/Insight%20into%20the%20global.pdf https://doi.org/10.1038/s41598-017-02206-0 en eng HAL CCSD Nature Publishing Group info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-017-02206-0 hal-01534743 https://hal.science/hal-01534743 https://hal.science/hal-01534743/document https://hal.science/hal-01534743/file/Insight%20into%20the%20global.pdf doi:10.1038/s41598-017-02206-0 info:eu-repo/semantics/OpenAccess ISSN: 2045-2322 EISSN: 2045-2322 Scientific Reports https://hal.science/hal-01534743 Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-02206-0⟩ [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases info:eu-repo/semantics/article Journal articles 2017 ftinserm https://doi.org/10.1038/s41598-017-02206-0 2024-07-22T23:41:42Z cited By 0 International audience One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain largely unstudied. The present study revealed, for the first time, that Rodentia associated UMRV emerged from a common ancestor in southern Africa more than 4000 years ago. Sequenced UMRV originating from different regions in the world, clustered into four well-supported viral lineages, which suggest that strain diversification occurred during host dispersal and associated exchanges, with purifying selection pressure as the principal evolutionary force. In addition, multi-introductions on different continents and islands of Rodentia associated UMRV and spillover between rodent species, most probably Rattus rattus, were detected and indicate that these animals are implicated in the vectoring and in the worldwide emergence of this virus group. The natural history and the evolution dynamics of these zoonotic viruses, originating from and hosted by wild animals, are most likely shaped by commensalism related to human activities. Article in Journal/Newspaper Rattus rattus Inserm: HAL (Institut national de la santé et de la recherche médicale) Scientific Reports 7 1 |
institution |
Open Polar |
collection |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
op_collection_id |
ftinserm |
language |
English |
topic |
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
spellingShingle |
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Ghawar, Wissem Pascalis, Hervé Bettaieb, Jihéne Mélade, Julien Gharbi, Adel Snoussi, Mohamed Ali Laouini, Dhafer Goodman, Steven M. Salah, Afif Ben Dellagi, Koussay Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
topic_facet |
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
description |
cited By 0 International audience One portion of the family Paramyxoviridae is a group of Unclassified Morbilli-Related Viruses (UMRV) recently recognized in wild small mammals. At a global level, the evolutionary history of these viruses is not properly understood and the relationships between UMRV and their hosts still remain largely unstudied. The present study revealed, for the first time, that Rodentia associated UMRV emerged from a common ancestor in southern Africa more than 4000 years ago. Sequenced UMRV originating from different regions in the world, clustered into four well-supported viral lineages, which suggest that strain diversification occurred during host dispersal and associated exchanges, with purifying selection pressure as the principal evolutionary force. In addition, multi-introductions on different continents and islands of Rodentia associated UMRV and spillover between rodent species, most probably Rattus rattus, were detected and indicate that these animals are implicated in the vectoring and in the worldwide emergence of this virus group. The natural history and the evolution dynamics of these zoonotic viruses, originating from and hosted by wild animals, are most likely shaped by commensalism related to human activities. |
author2 |
Université de Tunis El Manar (UTM) Institut Pasteur de Tunis Réseau International des Instituts Pasteur (RIIP) Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien (CRVOI) Université de La Réunion (UR) Processus Infectieux en Milieu Insulaire Tropical (PIMIT) Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS) Association Vahatra Antananarivo, Madagascar Field Museum of Natural History Chicago, USA Cyclotron Réunion Océan Indien (CYROI) Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion) Laboratoire de Transmission, Contrôle et Immunobiologie des Infections - Laboratory of Transmission, Control and Immunobiology of Infection (LR11IPT02) Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) |
format |
Article in Journal/Newspaper |
author |
Ghawar, Wissem Pascalis, Hervé Bettaieb, Jihéne Mélade, Julien Gharbi, Adel Snoussi, Mohamed Ali Laouini, Dhafer Goodman, Steven M. Salah, Afif Ben Dellagi, Koussay |
author_facet |
Ghawar, Wissem Pascalis, Hervé Bettaieb, Jihéne Mélade, Julien Gharbi, Adel Snoussi, Mohamed Ali Laouini, Dhafer Goodman, Steven M. Salah, Afif Ben Dellagi, Koussay |
author_sort |
Ghawar, Wissem |
title |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_short |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_full |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_fullStr |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_full_unstemmed |
Insight into the global evolution of Rodentia associated Morbilli-related paramyxoviruses |
title_sort |
insight into the global evolution of rodentia associated morbilli-related paramyxoviruses |
publisher |
HAL CCSD |
publishDate |
2017 |
url |
https://hal.science/hal-01534743 https://hal.science/hal-01534743/document https://hal.science/hal-01534743/file/Insight%20into%20the%20global.pdf https://doi.org/10.1038/s41598-017-02206-0 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
ISSN: 2045-2322 EISSN: 2045-2322 Scientific Reports https://hal.science/hal-01534743 Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-02206-0⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-017-02206-0 hal-01534743 https://hal.science/hal-01534743 https://hal.science/hal-01534743/document https://hal.science/hal-01534743/file/Insight%20into%20the%20global.pdf doi:10.1038/s41598-017-02206-0 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1038/s41598-017-02206-0 |
container_title |
Scientific Reports |
container_volume |
7 |
container_issue |
1 |
_version_ |
1810473811217219584 |