Natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from ORCA Study
International audience BACKGROUND: Early-onset atopic dermatitis (AD) is a particular phenotype that may convey a risk of developing multiple sensitizations to allergens but little is known about the pathway of sensitization. The aims of this study were to describe the natural history of sensitizati...
Published in: | Pediatric Allergy and Immunology |
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Main Authors: | , , , , , , , , , |
Other Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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HAL CCSD
2014
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Online Access: | https://hal.sorbonne-universite.fr/hal-01103219 https://hal.sorbonne-universite.fr/hal-01103219/document https://hal.sorbonne-universite.fr/hal-01103219/file/Just_2014_Natural_history_of.pdf https://doi.org/10.1111/pai.12287 |
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institution |
Open Polar |
collection |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
op_collection_id |
ftinserm |
language |
English |
topic |
cohort phenotypes food allergens inhaled allergens sensitization atopic dermatitis [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology |
spellingShingle |
cohort phenotypes food allergens inhaled allergens sensitization atopic dermatitis [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology Just, Jocelyne Deslandes-Boutmy, Emmanuelle Amat, Flore Desseaux, Kristell Nemni, Ariane Bourrat, Emmanuelle Sahraoui, Fatia Pansé, Isabelle Bagot, Martine Fouéré, Sébastien Natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from ORCA Study |
topic_facet |
cohort phenotypes food allergens inhaled allergens sensitization atopic dermatitis [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology |
description |
International audience BACKGROUND: Early-onset atopic dermatitis (AD) is a particular phenotype that may convey a risk of developing multiple sensitizations to allergens but little is known about the pathway of sensitization. The aims of this study were to describe the natural history of sensitization to allergens for this phenotype and to identify the most predictive marker associated with the risk of developing sensitization to inhaled allergens in a well-selected cohort of infants with AD.METHODS: Infants with active AD were enrolled and prospectively explored for biological markers of atopy every year until the age of 6 yr. Allergic sensitization was defined as the presence of positive specific IgEs to allergens and multiple sensitizations as being sensitized to ≥2 allergens. Elevated blood eosinophilia was defined as an eosinophil blood count ≥470 eosinophils/mm3 and elevated total IgE as a serum IgE level ≥45 kU/l.RESULTS: Two hundred and twenty-nine infants were included. Elevated blood eosinophilia was observed at baseline in 60 children (26.2%) and elevated total IgE in 85 (37.1%). When elevated at baseline, eosinophilia and IgE levels remained significantly higher during the follow-up period. Sensitization to food allergens decreased from 58% to 34%, whereas sensitization to inhaled allergens increased over time from 17% to 67%. Initial multiple sensitizations to food allergens were the most predictive factor for the risk of developing sensitization to inhaled allergens at 6 yr (OR 3.72 [1.68-8.30] p < 0.001).CONCLUSIONS: In the early-onset AD phenotype, multiple sensitization to food allergens conveys a higher risk of sensitization to inhaled allergens than single sensitization. |
author2 |
Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM) CHU Trousseau APHP Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) Service de biostatistique et d'informatique médicale Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Saint-Louis Service de dermatologie Paris Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
format |
Article in Journal/Newspaper |
author |
Just, Jocelyne Deslandes-Boutmy, Emmanuelle Amat, Flore Desseaux, Kristell Nemni, Ariane Bourrat, Emmanuelle Sahraoui, Fatia Pansé, Isabelle Bagot, Martine Fouéré, Sébastien |
author_facet |
Just, Jocelyne Deslandes-Boutmy, Emmanuelle Amat, Flore Desseaux, Kristell Nemni, Ariane Bourrat, Emmanuelle Sahraoui, Fatia Pansé, Isabelle Bagot, Martine Fouéré, Sébastien |
author_sort |
Just, Jocelyne |
title |
Natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from ORCA Study |
title_short |
Natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from ORCA Study |
title_full |
Natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from ORCA Study |
title_fullStr |
Natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from ORCA Study |
title_full_unstemmed |
Natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from ORCA Study |
title_sort |
natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from orca study |
publisher |
HAL CCSD |
publishDate |
2014 |
url |
https://hal.sorbonne-universite.fr/hal-01103219 https://hal.sorbonne-universite.fr/hal-01103219/document https://hal.sorbonne-universite.fr/hal-01103219/file/Just_2014_Natural_history_of.pdf https://doi.org/10.1111/pai.12287 |
genre |
Orca |
genre_facet |
Orca |
op_source |
ISSN: 0905-6157 EISSN: 1399-3038 Pediatric Allergy and Immunology https://hal.sorbonne-universite.fr/hal-01103219 Pediatric Allergy and Immunology, 2014, 25, pp.668-673 ⟨10.1111/pai.12287⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1111/pai.12287 info:eu-repo/semantics/altIdentifier/pmid/25283304 hal-01103219 https://hal.sorbonne-universite.fr/hal-01103219 https://hal.sorbonne-universite.fr/hal-01103219/document https://hal.sorbonne-universite.fr/hal-01103219/file/Just_2014_Natural_history_of.pdf doi:10.1111/pai.12287 PUBMED: 25283304 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1111/pai.12287 |
container_title |
Pediatric Allergy and Immunology |
container_volume |
25 |
container_issue |
7 |
container_start_page |
668 |
op_container_end_page |
673 |
_version_ |
1788064334750941184 |
spelling |
ftinserm:oai:HAL:hal-01103219v1 2024-01-14T10:09:45+01:00 Natural history of allergic sensitization in infants with early-onset atopic 1 dermatitis: results from ORCA Study Just, Jocelyne Deslandes-Boutmy, Emmanuelle Amat, Flore Desseaux, Kristell Nemni, Ariane Bourrat, Emmanuelle Sahraoui, Fatia Pansé, Isabelle Bagot, Martine Fouéré, Sébastien Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM) CHU Trousseau APHP Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) Service de biostatistique et d'informatique médicale Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Saint-Louis Service de dermatologie Paris Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) 2014-11-20 https://hal.sorbonne-universite.fr/hal-01103219 https://hal.sorbonne-universite.fr/hal-01103219/document https://hal.sorbonne-universite.fr/hal-01103219/file/Just_2014_Natural_history_of.pdf https://doi.org/10.1111/pai.12287 en eng HAL CCSD Wiley info:eu-repo/semantics/altIdentifier/doi/10.1111/pai.12287 info:eu-repo/semantics/altIdentifier/pmid/25283304 hal-01103219 https://hal.sorbonne-universite.fr/hal-01103219 https://hal.sorbonne-universite.fr/hal-01103219/document https://hal.sorbonne-universite.fr/hal-01103219/file/Just_2014_Natural_history_of.pdf doi:10.1111/pai.12287 PUBMED: 25283304 info:eu-repo/semantics/OpenAccess ISSN: 0905-6157 EISSN: 1399-3038 Pediatric Allergy and Immunology https://hal.sorbonne-universite.fr/hal-01103219 Pediatric Allergy and Immunology, 2014, 25, pp.668-673 ⟨10.1111/pai.12287⟩ cohort phenotypes food allergens inhaled allergens sensitization atopic dermatitis [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology info:eu-repo/semantics/article Journal articles 2014 ftinserm https://doi.org/10.1111/pai.12287 2023-12-20T17:33:29Z International audience BACKGROUND: Early-onset atopic dermatitis (AD) is a particular phenotype that may convey a risk of developing multiple sensitizations to allergens but little is known about the pathway of sensitization. The aims of this study were to describe the natural history of sensitization to allergens for this phenotype and to identify the most predictive marker associated with the risk of developing sensitization to inhaled allergens in a well-selected cohort of infants with AD.METHODS: Infants with active AD were enrolled and prospectively explored for biological markers of atopy every year until the age of 6 yr. Allergic sensitization was defined as the presence of positive specific IgEs to allergens and multiple sensitizations as being sensitized to ≥2 allergens. Elevated blood eosinophilia was defined as an eosinophil blood count ≥470 eosinophils/mm3 and elevated total IgE as a serum IgE level ≥45 kU/l.RESULTS: Two hundred and twenty-nine infants were included. Elevated blood eosinophilia was observed at baseline in 60 children (26.2%) and elevated total IgE in 85 (37.1%). When elevated at baseline, eosinophilia and IgE levels remained significantly higher during the follow-up period. Sensitization to food allergens decreased from 58% to 34%, whereas sensitization to inhaled allergens increased over time from 17% to 67%. Initial multiple sensitizations to food allergens were the most predictive factor for the risk of developing sensitization to inhaled allergens at 6 yr (OR 3.72 [1.68-8.30] p < 0.001).CONCLUSIONS: In the early-onset AD phenotype, multiple sensitization to food allergens conveys a higher risk of sensitization to inhaled allergens than single sensitization. Article in Journal/Newspaper Orca Inserm: HAL (Institut national de la santé et de la recherche médicale) Pediatric Allergy and Immunology 25 7 668 673 |