Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear
International audience Prior to winter, heterotherms retain polyunsaturated fatty acids ("PUFA"), resulting in enhanced energy savings during hibernation, through deeper and longer torpor bouts. Hibernating bears exhibit a less dramatic reduction (2-5 degrees C) in body temperature, but lo...
Published in: | Frontiers in Physiology |
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Main Authors: | , , , , , , , , , , , , |
Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2019
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Subjects: | |
Online Access: | https://hal.science/hal-02141629 https://hal.science/hal-02141629/document https://hal.science/hal-02141629/file/2019_Giroud_Frontiers%20in%20Physiology_1.pdf https://doi.org/10.3389/fphys.2019.00389 |
id |
ftinsalyonhal:oai:HAL:hal-02141629v1 |
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record_format |
openpolar |
institution |
Open Polar |
collection |
INSA Lyon HAL (Institut National des Sciences Appliquées) |
op_collection_id |
ftinsalyonhal |
language |
English |
topic |
hibernation body temperature metabolism fatty acids glycerophospholipids sphingomyelin ceramide [SDE]Environmental Sciences |
spellingShingle |
hibernation body temperature metabolism fatty acids glycerophospholipids sphingomyelin ceramide [SDE]Environmental Sciences Giroud, Sylvain Chery, Isabelle Bertile, Fabrice Bertrand-Michel, Justine Tascher, Georg Gauquelin-Koch, Guillemette Arnemo, Jon, M Swenson, Jon, M Singh, Navinder, E Lefai, Etienne Evans, Alina, M Simon, Chantal Blanc, Stéphane Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear |
topic_facet |
hibernation body temperature metabolism fatty acids glycerophospholipids sphingomyelin ceramide [SDE]Environmental Sciences |
description |
International audience Prior to winter, heterotherms retain polyunsaturated fatty acids ("PUFA"), resulting in enhanced energy savings during hibernation, through deeper and longer torpor bouts. Hibernating bears exhibit a less dramatic reduction (2-5 degrees C) in body temperature, but lower their metabolism to a degree close to that of small hibernators. We determined the lipid composition, via lipidomics, in skeletal muscle and white adipose tissues ("WAT"), to assess lipid retention, and in blood plasma, to reflect lipid trafficking, of winter hibernating and summer active wild Scandinavian brown bears (Ursus arctos). We found that the proportion of monounsaturated fatty acids in muscle of bears was significantly higher during winter. During hibernation, omega-3 PUFAs were retained in WAT and short-length fatty acids were released into the plasma. The analysis of individual lipid moieties indicated significant changes of specific fatty acids, which are in line with the observed seasonal shift in the major lipid categories and can be involved in specific regulations of metabolisms. These results strongly suggest that the shift in lipid composition is well conserved among hibernators, independent of body mass and of the animals' body temperature. |
author2 |
Research Institute of Wildlife Ecology, University of Veterinary Medicine, University of Veterinary Medicine Département Ecologie, Physiologie et Ethologie (DEPE-IPHC) Institut Pluridisciplinaire Hubert Curien (IPHC) Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC) MetaToul Lipidomics Institut des Maladies Métaboliques et Cardiovasculaires (I2MC) Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-MetaboHUB-MetaToul MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL) Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) Institut National Polytechnique (Toulouse) (Toulouse INP) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire de Toulouse (ENVT) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Centre National d'Études Spatiales Toulouse (CNES) Department of Forestry and Wildlife Management Hedmark University College Norwegian Institute for Nature Research (NINA) Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) Norwegian Environmental Agency; Swedish Environmental Protection Agency; Polish-Norwegian Research Program POL-NOR/198352/85/2013 Austrian Science Fund (FWF) P27267-B25 |
format |
Article in Journal/Newspaper |
author |
Giroud, Sylvain Chery, Isabelle Bertile, Fabrice Bertrand-Michel, Justine Tascher, Georg Gauquelin-Koch, Guillemette Arnemo, Jon, M Swenson, Jon, M Singh, Navinder, E Lefai, Etienne Evans, Alina, M Simon, Chantal Blanc, Stéphane |
author_facet |
Giroud, Sylvain Chery, Isabelle Bertile, Fabrice Bertrand-Michel, Justine Tascher, Georg Gauquelin-Koch, Guillemette Arnemo, Jon, M Swenson, Jon, M Singh, Navinder, E Lefai, Etienne Evans, Alina, M Simon, Chantal Blanc, Stéphane |
author_sort |
Giroud, Sylvain |
title |
Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear |
title_short |
Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear |
title_full |
Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear |
title_fullStr |
Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear |
title_full_unstemmed |
Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear |
title_sort |
lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear |
publisher |
HAL CCSD |
publishDate |
2019 |
url |
https://hal.science/hal-02141629 https://hal.science/hal-02141629/document https://hal.science/hal-02141629/file/2019_Giroud_Frontiers%20in%20Physiology_1.pdf https://doi.org/10.3389/fphys.2019.00389 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
ISSN: 1664-042X Frontiers in Physiology https://hal.science/hal-02141629 Frontiers in Physiology, 2019, 10, ⟨10.3389/fphys.2019.00389⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2019.00389 info:eu-repo/semantics/altIdentifier/pmid/31031634 hal-02141629 https://hal.science/hal-02141629 https://hal.science/hal-02141629/document https://hal.science/hal-02141629/file/2019_Giroud_Frontiers%20in%20Physiology_1.pdf doi:10.3389/fphys.2019.00389 PRODINRA: 481030 PUBMED: 31031634 WOS: 000464460300001 |
op_rights |
http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.3389/fphys.2019.00389 |
container_title |
Frontiers in Physiology |
container_volume |
10 |
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1810484533778186240 |
spelling |
ftinsalyonhal:oai:HAL:hal-02141629v1 2024-09-15T18:40:13+00:00 Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear Giroud, Sylvain Chery, Isabelle Bertile, Fabrice Bertrand-Michel, Justine Tascher, Georg Gauquelin-Koch, Guillemette Arnemo, Jon, M Swenson, Jon, M Singh, Navinder, E Lefai, Etienne Evans, Alina, M Simon, Chantal Blanc, Stéphane Research Institute of Wildlife Ecology, University of Veterinary Medicine, University of Veterinary Medicine Département Ecologie, Physiologie et Ethologie (DEPE-IPHC) Institut Pluridisciplinaire Hubert Curien (IPHC) Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC) MetaToul Lipidomics Institut des Maladies Métaboliques et Cardiovasculaires (I2MC) Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-MetaboHUB-MetaToul MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL) Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) Institut National Polytechnique (Toulouse) (Toulouse INP) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire de Toulouse (ENVT) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Centre National d'Études Spatiales Toulouse (CNES) Department of Forestry and Wildlife Management Hedmark University College Norwegian Institute for Nature Research (NINA) Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) Norwegian Environmental Agency; Swedish Environmental Protection Agency; Polish-Norwegian Research Program POL-NOR/198352/85/2013 Austrian Science Fund (FWF) P27267-B25 2019 https://hal.science/hal-02141629 https://hal.science/hal-02141629/document https://hal.science/hal-02141629/file/2019_Giroud_Frontiers%20in%20Physiology_1.pdf https://doi.org/10.3389/fphys.2019.00389 en eng HAL CCSD Frontiers info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2019.00389 info:eu-repo/semantics/altIdentifier/pmid/31031634 hal-02141629 https://hal.science/hal-02141629 https://hal.science/hal-02141629/document https://hal.science/hal-02141629/file/2019_Giroud_Frontiers%20in%20Physiology_1.pdf doi:10.3389/fphys.2019.00389 PRODINRA: 481030 PUBMED: 31031634 WOS: 000464460300001 http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess ISSN: 1664-042X Frontiers in Physiology https://hal.science/hal-02141629 Frontiers in Physiology, 2019, 10, ⟨10.3389/fphys.2019.00389⟩ hibernation body temperature metabolism fatty acids glycerophospholipids sphingomyelin ceramide [SDE]Environmental Sciences info:eu-repo/semantics/article Journal articles 2019 ftinsalyonhal https://doi.org/10.3389/fphys.2019.00389 2024-07-24T23:31:23Z International audience Prior to winter, heterotherms retain polyunsaturated fatty acids ("PUFA"), resulting in enhanced energy savings during hibernation, through deeper and longer torpor bouts. Hibernating bears exhibit a less dramatic reduction (2-5 degrees C) in body temperature, but lower their metabolism to a degree close to that of small hibernators. We determined the lipid composition, via lipidomics, in skeletal muscle and white adipose tissues ("WAT"), to assess lipid retention, and in blood plasma, to reflect lipid trafficking, of winter hibernating and summer active wild Scandinavian brown bears (Ursus arctos). We found that the proportion of monounsaturated fatty acids in muscle of bears was significantly higher during winter. During hibernation, omega-3 PUFAs were retained in WAT and short-length fatty acids were released into the plasma. The analysis of individual lipid moieties indicated significant changes of specific fatty acids, which are in line with the observed seasonal shift in the major lipid categories and can be involved in specific regulations of metabolisms. These results strongly suggest that the shift in lipid composition is well conserved among hibernators, independent of body mass and of the animals' body temperature. Article in Journal/Newspaper Ursus arctos INSA Lyon HAL (Institut National des Sciences Appliquées) Frontiers in Physiology 10 |