The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus).
Melano-macrophage aggregates, collections of specialized cells of the innate immune system of fish, are considered a general biomarker for contaminant toxicity. To elucidate further the relationship between macrophage aggregates and metals exposure, yelloweye rockfish (Sebastes ruberrimus), a long-l...
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Online Access: | https://espace.inrs.ca/id/eprint/3712/ https://doi.org/10.1002/etc.3009 |
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ftinrsquebec:oai:espace.inrs.ca:3712 2023-05-15T18:03:32+02:00 The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). Barst, Benjamin D. Bridges, Kristin Korbas, Malgorzata Roberts, Aaron P. Van Kirk, Kray McNeel, Kevin Drevnick, Paul E. 2015 https://espace.inrs.ca/id/eprint/3712/ https://doi.org/10.1002/etc.3009 unknown Barst, Benjamin D., Bridges, Kristin, Korbas, Malgorzata, Roberts, Aaron P., Van Kirk, Kray, McNeel, Kevin et Drevnick, Paul E. (2015). The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). Environmental Toxicology and Chemistry , vol. 34 , nº 8. p. 1918-1925. DOI:10.1002/etc.3009 <https://doi.org/10.1002/etc.3009>. doi:10.1002/etc.3009 melano-macrophage aggregates mercury metals LA-ICP-MS X-ray fluorescence imaging Article Évalué par les pairs 2015 ftinrsquebec https://doi.org/10.1002/etc.3009 2023-02-10T11:42:39Z Melano-macrophage aggregates, collections of specialized cells of the innate immune system of fish, are considered a general biomarker for contaminant toxicity. To elucidate further the relationship between macrophage aggregates and metals exposure, yelloweye rockfish (Sebastes ruberrimus), a long-lived species, were sampled from the east and west coasts of Prince of Wales Island, Alaska. Metals concentrations in livers (inorganic Hg, methyl mercury, Se, Ni, Cd, Cu, Zn) and spleens (inorganic Hg and methyl mercury) were determined, as well as their correlations with melano-macrophage aggregate area. Sections of liver tissue were analyzed by laser ablation-inductively coupled plasma-mass spectrometry to determine how metals were spatially distributed between hepatocytes and macrophage aggregates. The concentration of inorganic Hg in whole tissue was the best predictor of macrophage area in yelloweye livers and spleens. Macrophage aggregates had higher relative concentrations than most metals compared with the surrounding hepatocytes. However, not all metals were accumulated to the same degree, as evidenced by differences in the ratios of metals in macrophages compared with hepatocytes. Laser ablation data were corroborated with the results of X-ray synchrotron fluorescence imaging of a yelloweye liver section. Hepatic macrophage aggregates in yelloweye rockfish may play an important role in the detoxification and storage of Hg and other metals. Article in Journal/Newspaper Prince of Wales Island Alaska Institut national de la recherche scientifique, Québec: Espace INRS Prince of Wales Island ENVELOPE(-99.001,-99.001,72.668,72.668) Environmental Toxicology and Chemistry 34 8 1918 1925 |
institution |
Open Polar |
collection |
Institut national de la recherche scientifique, Québec: Espace INRS |
op_collection_id |
ftinrsquebec |
language |
unknown |
topic |
melano-macrophage aggregates mercury metals LA-ICP-MS X-ray fluorescence imaging |
spellingShingle |
melano-macrophage aggregates mercury metals LA-ICP-MS X-ray fluorescence imaging Barst, Benjamin D. Bridges, Kristin Korbas, Malgorzata Roberts, Aaron P. Van Kirk, Kray McNeel, Kevin Drevnick, Paul E. The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). |
topic_facet |
melano-macrophage aggregates mercury metals LA-ICP-MS X-ray fluorescence imaging |
description |
Melano-macrophage aggregates, collections of specialized cells of the innate immune system of fish, are considered a general biomarker for contaminant toxicity. To elucidate further the relationship between macrophage aggregates and metals exposure, yelloweye rockfish (Sebastes ruberrimus), a long-lived species, were sampled from the east and west coasts of Prince of Wales Island, Alaska. Metals concentrations in livers (inorganic Hg, methyl mercury, Se, Ni, Cd, Cu, Zn) and spleens (inorganic Hg and methyl mercury) were determined, as well as their correlations with melano-macrophage aggregate area. Sections of liver tissue were analyzed by laser ablation-inductively coupled plasma-mass spectrometry to determine how metals were spatially distributed between hepatocytes and macrophage aggregates. The concentration of inorganic Hg in whole tissue was the best predictor of macrophage area in yelloweye livers and spleens. Macrophage aggregates had higher relative concentrations than most metals compared with the surrounding hepatocytes. However, not all metals were accumulated to the same degree, as evidenced by differences in the ratios of metals in macrophages compared with hepatocytes. Laser ablation data were corroborated with the results of X-ray synchrotron fluorescence imaging of a yelloweye liver section. Hepatic macrophage aggregates in yelloweye rockfish may play an important role in the detoxification and storage of Hg and other metals. |
format |
Article in Journal/Newspaper |
author |
Barst, Benjamin D. Bridges, Kristin Korbas, Malgorzata Roberts, Aaron P. Van Kirk, Kray McNeel, Kevin Drevnick, Paul E. |
author_facet |
Barst, Benjamin D. Bridges, Kristin Korbas, Malgorzata Roberts, Aaron P. Van Kirk, Kray McNeel, Kevin Drevnick, Paul E. |
author_sort |
Barst, Benjamin D. |
title |
The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). |
title_short |
The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). |
title_full |
The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). |
title_fullStr |
The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). |
title_full_unstemmed |
The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). |
title_sort |
role of melano-macrophage aggregates in the storage of mercury and other metals: an example from yelloweye rockfish (sebastes ruberrimus). |
publishDate |
2015 |
url |
https://espace.inrs.ca/id/eprint/3712/ https://doi.org/10.1002/etc.3009 |
long_lat |
ENVELOPE(-99.001,-99.001,72.668,72.668) |
geographic |
Prince of Wales Island |
geographic_facet |
Prince of Wales Island |
genre |
Prince of Wales Island Alaska |
genre_facet |
Prince of Wales Island Alaska |
op_relation |
Barst, Benjamin D., Bridges, Kristin, Korbas, Malgorzata, Roberts, Aaron P., Van Kirk, Kray, McNeel, Kevin et Drevnick, Paul E. (2015). The role of melano-macrophage aggregates in the storage of mercury and other metals: An example from yelloweye rockfish (Sebastes ruberrimus). Environmental Toxicology and Chemistry , vol. 34 , nº 8. p. 1918-1925. DOI:10.1002/etc.3009 <https://doi.org/10.1002/etc.3009>. doi:10.1002/etc.3009 |
op_doi |
https://doi.org/10.1002/etc.3009 |
container_title |
Environmental Toxicology and Chemistry |
container_volume |
34 |
container_issue |
8 |
container_start_page |
1918 |
op_container_end_page |
1925 |
_version_ |
1766174411833999360 |