Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear
Prior to winter, heterotherms retain polyunsaturated fatty acids ("PUFA"), resulting in enhanced energy savings during hibernation, through deeper and longer torpor bouts. Hibernating bears exhibit a less dramatic reduction (2-5 degrees C) in body temperature, but lower their metabolism to...
Published in: | Frontiers in Physiology |
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Online Access: | http://prodinra.inra.fr/ft/2E999D41-BF95-4F9E-A6BD-7BA39E6829D7 http://prodinra.inra.fr/record/481030 https://doi.org/10.3389/fphys.2019.00389 |
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ftinraparis:oai:prodinra.inra.fr:481030 2023-05-15T18:42:05+02:00 Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear Chery, Isabelle Bertile, Fabrice Bertrand-Michel , Justine Tascher, Georg Gauquelin-Koch, Guillemette Arnemo, Jon M. Swenson, Jon E. Singh, Navinder J. Lefai, Etienne Evans, Aline L. Simon, Chantal Blanc, Stéphane Giroud, Sylvain 2019 application/pdf http://prodinra.inra.fr/ft/2E999D41-BF95-4F9E-A6BD-7BA39E6829D7 http://prodinra.inra.fr/record/481030 https://doi.org/10.3389/fphys.2019.00389 eng eng https://creativecommons.org/licenses/by/3.0/ CC-BY Frontiers in Physiology (10), . (2019) hibernation;body temperature;metabolism;fatty acids;glycerophospholipids;sphingomyelin;ceramide ARTICLE 2019 ftinraparis https://doi.org/10.3389/fphys.2019.00389 2019-08-27T22:25:25Z Prior to winter, heterotherms retain polyunsaturated fatty acids ("PUFA"), resulting in enhanced energy savings during hibernation, through deeper and longer torpor bouts. Hibernating bears exhibit a less dramatic reduction (2-5 degrees C) in body temperature, but lower their metabolism to a degree close to that of small hibernators. We determined the lipid composition, via lipidomics, in skeletal muscle and white adipose tissues ("WAT"), to assess lipid retention, and in blood plasma, to reflect lipid trafficking, of winter hibernating and summer active wild Scandinavian brown bears (Ursus arctos). We found that the proportion of monounsaturated fatty acids in muscle of bears was significantly higher during winter. During hibernation, omega-3 PUFAs were retained in WAT and short-length fatty acids were released into the plasma. The analysis of individual lipid moieties indicated significant changes of specific fatty acids, which are in line with the observed seasonal shift in the major lipid categories and can be involved in specific regulations of metabolisms. These results strongly suggest that the shift in lipid composition is well conserved among hibernators, independent of body mass and of the animals' body temperature. Article in Journal/Newspaper Ursus arctos Institut National de la Recherche Agronomique: ProdINRA Frontiers in Physiology 10 |
institution |
Open Polar |
collection |
Institut National de la Recherche Agronomique: ProdINRA |
op_collection_id |
ftinraparis |
language |
English |
topic |
hibernation;body temperature;metabolism;fatty acids;glycerophospholipids;sphingomyelin;ceramide |
spellingShingle |
hibernation;body temperature;metabolism;fatty acids;glycerophospholipids;sphingomyelin;ceramide Chery, Isabelle Bertile, Fabrice Bertrand-Michel , Justine Tascher, Georg Gauquelin-Koch, Guillemette Arnemo, Jon M. Swenson, Jon E. Singh, Navinder J. Lefai, Etienne Evans, Aline L. Simon, Chantal Blanc, Stéphane Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear |
topic_facet |
hibernation;body temperature;metabolism;fatty acids;glycerophospholipids;sphingomyelin;ceramide |
description |
Prior to winter, heterotherms retain polyunsaturated fatty acids ("PUFA"), resulting in enhanced energy savings during hibernation, through deeper and longer torpor bouts. Hibernating bears exhibit a less dramatic reduction (2-5 degrees C) in body temperature, but lower their metabolism to a degree close to that of small hibernators. We determined the lipid composition, via lipidomics, in skeletal muscle and white adipose tissues ("WAT"), to assess lipid retention, and in blood plasma, to reflect lipid trafficking, of winter hibernating and summer active wild Scandinavian brown bears (Ursus arctos). We found that the proportion of monounsaturated fatty acids in muscle of bears was significantly higher during winter. During hibernation, omega-3 PUFAs were retained in WAT and short-length fatty acids were released into the plasma. The analysis of individual lipid moieties indicated significant changes of specific fatty acids, which are in line with the observed seasonal shift in the major lipid categories and can be involved in specific regulations of metabolisms. These results strongly suggest that the shift in lipid composition is well conserved among hibernators, independent of body mass and of the animals' body temperature. |
author2 |
Giroud, Sylvain |
format |
Article in Journal/Newspaper |
author |
Chery, Isabelle Bertile, Fabrice Bertrand-Michel , Justine Tascher, Georg Gauquelin-Koch, Guillemette Arnemo, Jon M. Swenson, Jon E. Singh, Navinder J. Lefai, Etienne Evans, Aline L. Simon, Chantal Blanc, Stéphane |
author_facet |
Chery, Isabelle Bertile, Fabrice Bertrand-Michel , Justine Tascher, Georg Gauquelin-Koch, Guillemette Arnemo, Jon M. Swenson, Jon E. Singh, Navinder J. Lefai, Etienne Evans, Aline L. Simon, Chantal Blanc, Stéphane |
author_sort |
Chery, Isabelle |
title |
Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear |
title_short |
Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear |
title_full |
Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear |
title_fullStr |
Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear |
title_full_unstemmed |
Lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear |
title_sort |
lipidomics reveals seasonal shifts in a large-bodied hibernator, the brown bear |
publishDate |
2019 |
url |
http://prodinra.inra.fr/ft/2E999D41-BF95-4F9E-A6BD-7BA39E6829D7 http://prodinra.inra.fr/record/481030 https://doi.org/10.3389/fphys.2019.00389 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Frontiers in Physiology (10), . (2019) |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fphys.2019.00389 |
container_title |
Frontiers in Physiology |
container_volume |
10 |
_version_ |
1766231691253252096 |