Compilation of QTL for resistance to bacterial, parasitic and viral diseases in turbot (Scophthalmus maximus)
The culture of turbot is a well-established process. However, several infectious diseases caused by bacteria, parasites and viruses represent one of the most relevant limiting factors, causing severe economic losses. Consequently, one of the main objectives of genetic breeding programs in turbot ind...
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ftinraparis:oai:prodinra.inra.fr:476187 2023-05-15T18:15:52+02:00 Compilation of QTL for resistance to bacterial, parasitic and viral diseases in turbot (Scophthalmus maximus) Rodriguez Ramilo, Silvia Téresa De La Herrán, Roberto Ruiz Rejon, C. Herminda, M. Fernández, C. Pereiro, P. Novoa, B. Figueras, A. Bouza, C. Toro, M. A. Martinez , P. Fernández, J. 2015 application/pdf http://prodinra.inra.fr/ft/40698D6F-CF93-4523-A011-592A2639D9EB http://prodinra.inra.fr/record/476187 eng eng https://creativecommons.org/licenses/by-sa/3.0/ CC-BY-SA ISGA XII. International Symposium on Genetics in Aquaculture XII, Santiago de Compostela, ESP, 2015-06-21-2015-06-27 Autre (Sciences du Vivant) quantitative trait loci;molecular marker;general immunity;specific immunity;marker assisted selection PAPER 2015 ftinraparis 2019-07-09T22:25:43Z The culture of turbot is a well-established process. However, several infectious diseases caused by bacteria, parasites and viruses represent one of the most relevant limiting factors, causing severe economic losses. Consequently, one of the main objectives of genetic breeding programs in turbot industry is to reduce disease-related problems (mortality, slow growth, etc.). The objective of this study was to identify specific and general disease-resistance genomic regions related to the main pathogens for turbot culture. For this purpose, a comparison between QTL detected for resistance and survival time to the bacteria Aeromonas salmonicida (furunculosis), the parasite Philasterides dicentrarchi (scuticociliatosis) and the haemorrhagic septicaemia virus (VHS) was carried out. Eleven full-sib families of approximately 100 individuals each were analysed. Four families were evaluated for resistance to furunculosis, 3 families were tested for VHS, and 4 families were analysed for scuticociliatosis. All individuals were analysed with the same consensus genetic map. Several linkage groups (LG1, LG5 and LG6) showed QTL associated to the response to the three pathogens, suggesting genomic regions involved in general immunity. Notwithstanding, some disease specific genomic regions were also detected for furunculosis (LG12 and LG18), scuticociliatosis (LG3, LG7, LG10 and LG23) and VHS (LG8, LG20 and LG21). Additionally, other linkage groups shared common QTL for furunculosis and scuticociliatosis (LG4, LG9, LG11, LG13 and LG16), and for scuticociliatosis and VHS (LG2, LG15 and LG17). No QTL involved in the resistance/ survival to any of the three pathogens were detected in LG14, LG19 and LG22. A gene mining approach identified candidate genes related to general or specific immunity. These findings will aid to develop marker assisted selection programs to improve turbot production. Report Scophthalmus maximus Turbot Institut National de la Recherche Agronomique: ProdINRA |
institution |
Open Polar |
collection |
Institut National de la Recherche Agronomique: ProdINRA |
op_collection_id |
ftinraparis |
language |
English |
topic |
Autre (Sciences du Vivant) quantitative trait loci;molecular marker;general immunity;specific immunity;marker assisted selection |
spellingShingle |
Autre (Sciences du Vivant) quantitative trait loci;molecular marker;general immunity;specific immunity;marker assisted selection Rodriguez Ramilo, Silvia Téresa De La Herrán, Roberto Ruiz Rejon, C. Herminda, M. Fernández, C. Pereiro, P. Novoa, B. Figueras, A. Bouza, C. Toro, M. A. Martinez , P. Fernández, J. Compilation of QTL for resistance to bacterial, parasitic and viral diseases in turbot (Scophthalmus maximus) |
topic_facet |
Autre (Sciences du Vivant) quantitative trait loci;molecular marker;general immunity;specific immunity;marker assisted selection |
description |
The culture of turbot is a well-established process. However, several infectious diseases caused by bacteria, parasites and viruses represent one of the most relevant limiting factors, causing severe economic losses. Consequently, one of the main objectives of genetic breeding programs in turbot industry is to reduce disease-related problems (mortality, slow growth, etc.). The objective of this study was to identify specific and general disease-resistance genomic regions related to the main pathogens for turbot culture. For this purpose, a comparison between QTL detected for resistance and survival time to the bacteria Aeromonas salmonicida (furunculosis), the parasite Philasterides dicentrarchi (scuticociliatosis) and the haemorrhagic septicaemia virus (VHS) was carried out. Eleven full-sib families of approximately 100 individuals each were analysed. Four families were evaluated for resistance to furunculosis, 3 families were tested for VHS, and 4 families were analysed for scuticociliatosis. All individuals were analysed with the same consensus genetic map. Several linkage groups (LG1, LG5 and LG6) showed QTL associated to the response to the three pathogens, suggesting genomic regions involved in general immunity. Notwithstanding, some disease specific genomic regions were also detected for furunculosis (LG12 and LG18), scuticociliatosis (LG3, LG7, LG10 and LG23) and VHS (LG8, LG20 and LG21). Additionally, other linkage groups shared common QTL for furunculosis and scuticociliatosis (LG4, LG9, LG11, LG13 and LG16), and for scuticociliatosis and VHS (LG2, LG15 and LG17). No QTL involved in the resistance/ survival to any of the three pathogens were detected in LG14, LG19 and LG22. A gene mining approach identified candidate genes related to general or specific immunity. These findings will aid to develop marker assisted selection programs to improve turbot production. |
format |
Report |
author |
Rodriguez Ramilo, Silvia Téresa De La Herrán, Roberto Ruiz Rejon, C. Herminda, M. Fernández, C. Pereiro, P. Novoa, B. Figueras, A. Bouza, C. Toro, M. A. Martinez , P. Fernández, J. |
author_facet |
Rodriguez Ramilo, Silvia Téresa De La Herrán, Roberto Ruiz Rejon, C. Herminda, M. Fernández, C. Pereiro, P. Novoa, B. Figueras, A. Bouza, C. Toro, M. A. Martinez , P. Fernández, J. |
author_sort |
Rodriguez Ramilo, Silvia Téresa |
title |
Compilation of QTL for resistance to bacterial, parasitic and viral diseases in turbot (Scophthalmus maximus) |
title_short |
Compilation of QTL for resistance to bacterial, parasitic and viral diseases in turbot (Scophthalmus maximus) |
title_full |
Compilation of QTL for resistance to bacterial, parasitic and viral diseases in turbot (Scophthalmus maximus) |
title_fullStr |
Compilation of QTL for resistance to bacterial, parasitic and viral diseases in turbot (Scophthalmus maximus) |
title_full_unstemmed |
Compilation of QTL for resistance to bacterial, parasitic and viral diseases in turbot (Scophthalmus maximus) |
title_sort |
compilation of qtl for resistance to bacterial, parasitic and viral diseases in turbot (scophthalmus maximus) |
publishDate |
2015 |
url |
http://prodinra.inra.fr/ft/40698D6F-CF93-4523-A011-592A2639D9EB http://prodinra.inra.fr/record/476187 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
ISGA XII. International Symposium on Genetics in Aquaculture XII, Santiago de Compostela, ESP, 2015-06-21-2015-06-27 |
op_rights |
https://creativecommons.org/licenses/by-sa/3.0/ |
op_rightsnorm |
CC-BY-SA |
_version_ |
1766189098140172288 |