Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal
Bioinvasion is a major public health issue because it can lead to the introduction of pathogens in new areas and favours the emergence of zoonotic diseases. Rodents are prominent invasive species, and act as reservoirs in many zoonotic infectious diseases. The aim of this study was to determine the...
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ftinraparis:oai:prodinra.inra.fr:437162 2023-05-15T18:05:35+02:00 Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal Cassan, Cecile Diagne, Christophe Amidi Tatard, Caroline Gauthier, Philippe Dalecky, Ambroise Ba, Khalilou Kane, Mamadou Niang, Youssoupha Diallo, Mamoudou SOW, Aliou Brouat, Carine Banuls, Anne-Laure 2018 application/pdf http://prodinra.inra.fr/ft/90DF7E92-CE92-4E70-B3EB-C37729A13403 http://prodinra.inra.fr/record/437162 https://doi.org/10.1371/journal.pntd.0006615 eng eng https://creativecommons.org/licenses/by/3.0/ CC-BY Plos Neglected Tropical Diseases 6 (12), . (2018) Biologie animale Animal biology ARTICLE 2018 ftinraparis https://doi.org/10.1371/journal.pntd.0006615 2018-07-24T22:24:46Z Bioinvasion is a major public health issue because it can lead to the introduction of pathogens in new areas and favours the emergence of zoonotic diseases. Rodents are prominent invasive species, and act as reservoirs in many zoonotic infectious diseases. The aim of this study was to determine the link between the distribution and spread of two parasite taxa (Leishmania spp. and Trypanosoma lewisi) and the progressive invasion of Senegal by two commensal rodent species (the house mouse Mus musculus domesticus and the black rat Rattus rattus). M. m. domesticus and R. rattus have invaded the northern part and the central/ southern part of the country, respectively. Native and invasive rodents were caught in villages and cities along the invasion gradients of both invaders, from coastal localities towards the interior of the land. Molecular diagnosis of the two trypanosomatid infections was performed using spleen specimens. In the north, neither M. m. domesticus nor the native species were carriers of these parasites. Conversely, in the south, 17.5% of R. rattus were infected by L. major and 27.8% by T. lewisi, while very few commensal native rodents were carriers. Prevalence pattern along invasion gradients, together with the knowledge on the geographical distribution of the parasites, suggested that the presence of the two parasites in R. rattus in Senegal is of different origins. Indeed, the invader R. rattus could have been locally infected by the native parasite L. major. Conversely, it could have introduced the exotic parasite T. lewisi in Senegal, the latter appearing to be poorly transmitted to native rodents. Altogether, these data show that R. rattus is a carrier of both parasites and could be responsible for the emergence of new foci of cutaneous leishmaniasis, or for the transmission of atypical human trypanosomiasis in Senegal. Article in Journal/Newspaper Rattus rattus Institut National de la Recherche Agronomique: ProdINRA PLOS Neglected Tropical Diseases 12 6 e0006615 |
institution |
Open Polar |
collection |
Institut National de la Recherche Agronomique: ProdINRA |
op_collection_id |
ftinraparis |
language |
English |
topic |
Biologie animale Animal biology |
spellingShingle |
Biologie animale Animal biology Cassan, Cecile Diagne, Christophe Amidi Tatard, Caroline Gauthier, Philippe Dalecky, Ambroise Ba, Khalilou Kane, Mamadou Niang, Youssoupha Diallo, Mamoudou SOW, Aliou Brouat, Carine Banuls, Anne-Laure Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
topic_facet |
Biologie animale Animal biology |
description |
Bioinvasion is a major public health issue because it can lead to the introduction of pathogens in new areas and favours the emergence of zoonotic diseases. Rodents are prominent invasive species, and act as reservoirs in many zoonotic infectious diseases. The aim of this study was to determine the link between the distribution and spread of two parasite taxa (Leishmania spp. and Trypanosoma lewisi) and the progressive invasion of Senegal by two commensal rodent species (the house mouse Mus musculus domesticus and the black rat Rattus rattus). M. m. domesticus and R. rattus have invaded the northern part and the central/ southern part of the country, respectively. Native and invasive rodents were caught in villages and cities along the invasion gradients of both invaders, from coastal localities towards the interior of the land. Molecular diagnosis of the two trypanosomatid infections was performed using spleen specimens. In the north, neither M. m. domesticus nor the native species were carriers of these parasites. Conversely, in the south, 17.5% of R. rattus were infected by L. major and 27.8% by T. lewisi, while very few commensal native rodents were carriers. Prevalence pattern along invasion gradients, together with the knowledge on the geographical distribution of the parasites, suggested that the presence of the two parasites in R. rattus in Senegal is of different origins. Indeed, the invader R. rattus could have been locally infected by the native parasite L. major. Conversely, it could have introduced the exotic parasite T. lewisi in Senegal, the latter appearing to be poorly transmitted to native rodents. Altogether, these data show that R. rattus is a carrier of both parasites and could be responsible for the emergence of new foci of cutaneous leishmaniasis, or for the transmission of atypical human trypanosomiasis in Senegal. |
format |
Article in Journal/Newspaper |
author |
Cassan, Cecile Diagne, Christophe Amidi Tatard, Caroline Gauthier, Philippe Dalecky, Ambroise Ba, Khalilou Kane, Mamadou Niang, Youssoupha Diallo, Mamoudou SOW, Aliou Brouat, Carine Banuls, Anne-Laure |
author_facet |
Cassan, Cecile Diagne, Christophe Amidi Tatard, Caroline Gauthier, Philippe Dalecky, Ambroise Ba, Khalilou Kane, Mamadou Niang, Youssoupha Diallo, Mamoudou SOW, Aliou Brouat, Carine Banuls, Anne-Laure |
author_sort |
Cassan, Cecile |
title |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_short |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_full |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_fullStr |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_full_unstemmed |
Leishmania major and Trypanosoma lewisi infection in invasive and native rodents in Senegal |
title_sort |
leishmania major and trypanosoma lewisi infection in invasive and native rodents in senegal |
publishDate |
2018 |
url |
http://prodinra.inra.fr/ft/90DF7E92-CE92-4E70-B3EB-C37729A13403 http://prodinra.inra.fr/record/437162 https://doi.org/10.1371/journal.pntd.0006615 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Plos Neglected Tropical Diseases 6 (12), . (2018) |
op_rights |
https://creativecommons.org/licenses/by/3.0/ |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pntd.0006615 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
6 |
container_start_page |
e0006615 |
_version_ |
1766177062525075456 |