Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids
This work reports the first lipase-catalyzed reactions between substrates of different polarities using deep eutectic solvents as a medium. The model reaction consisted of a lipophilization process based on the alcoholysis of phenolic esters using immobilized Candida antarctica lipase B as a biocata...
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ftinraparis:oai:HAL:hal-01227411v1 2024-06-23T07:46:33+00:00 Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids Durand, Erwann Lecomte, Jérôme Barea, Bruno Dubreucq, Eric Lortie, Robert Villeneuve, Pierre Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro) National Research Council of Canada (NRC) 2013 https://hal.science/hal-01227411 https://doi.org/10.1039/c3gc40899j en eng HAL CCSD Royal Society of Chemistry info:eu-repo/semantics/altIdentifier/doi/10.1039/c3gc40899j hal-01227411 https://hal.science/hal-01227411 doi:10.1039/c3gc40899j PRODINRA: 332459 WOS: 000322121400033 ISSN: 1463-9262 EISSN: 1463-9270 Green Chemistry https://hal.science/hal-01227411 Green Chemistry, 2013, 15 (8), pp.2275-2282. ⟨10.1039/c3gc40899j⟩ [CHIM.GENI]Chemical Sciences/Chemical engineering [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] info:eu-repo/semantics/article Journal articles 2013 ftinraparis https://doi.org/10.1039/c3gc40899j 2024-06-04T15:24:39Z This work reports the first lipase-catalyzed reactions between substrates of different polarities using deep eutectic solvents as a medium. The model reaction consisted of a lipophilization process based on the alcoholysis of phenolic esters using immobilized Candida antarctica lipase B as a biocatalyst. Results showed that water could dramatically improve the lipase activity and change the reactivity of phenolic substrates. Indeed, very low conversions (<2%) were observed in pure DES, whereas in DES–water binary mixtures, quantitative conversions were achieved. After investigating the role of various parameters, such as the substrate concentration and ratio, pH or thermodynamic activity of water, the effect of the presence of water in pure DES based on urea or glycerol was discussed. In this paper, we propose new perspectives for the enzymatic modification of polar substrates using this novel generation of green, inexpensive and easy-to-handle solvents. Article in Journal/Newspaper Antarc* Antarctica Institut National de la Recherche Agronomique: ProdINRA Green Chemistry 15 8 2275 |
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Institut National de la Recherche Agronomique: ProdINRA |
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language |
English |
topic |
[CHIM.GENI]Chemical Sciences/Chemical engineering [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] |
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[CHIM.GENI]Chemical Sciences/Chemical engineering [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] Durand, Erwann Lecomte, Jérôme Barea, Bruno Dubreucq, Eric Lortie, Robert Villeneuve, Pierre Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids |
topic_facet |
[CHIM.GENI]Chemical Sciences/Chemical engineering [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] |
description |
This work reports the first lipase-catalyzed reactions between substrates of different polarities using deep eutectic solvents as a medium. The model reaction consisted of a lipophilization process based on the alcoholysis of phenolic esters using immobilized Candida antarctica lipase B as a biocatalyst. Results showed that water could dramatically improve the lipase activity and change the reactivity of phenolic substrates. Indeed, very low conversions (<2%) were observed in pure DES, whereas in DES–water binary mixtures, quantitative conversions were achieved. After investigating the role of various parameters, such as the substrate concentration and ratio, pH or thermodynamic activity of water, the effect of the presence of water in pure DES based on urea or glycerol was discussed. In this paper, we propose new perspectives for the enzymatic modification of polar substrates using this novel generation of green, inexpensive and easy-to-handle solvents. |
author2 |
Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro) National Research Council of Canada (NRC) |
format |
Article in Journal/Newspaper |
author |
Durand, Erwann Lecomte, Jérôme Barea, Bruno Dubreucq, Eric Lortie, Robert Villeneuve, Pierre |
author_facet |
Durand, Erwann Lecomte, Jérôme Barea, Bruno Dubreucq, Eric Lortie, Robert Villeneuve, Pierre |
author_sort |
Durand, Erwann |
title |
Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids |
title_short |
Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids |
title_full |
Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids |
title_fullStr |
Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids |
title_full_unstemmed |
Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids |
title_sort |
evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids |
publisher |
HAL CCSD |
publishDate |
2013 |
url |
https://hal.science/hal-01227411 https://doi.org/10.1039/c3gc40899j |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
ISSN: 1463-9262 EISSN: 1463-9270 Green Chemistry https://hal.science/hal-01227411 Green Chemistry, 2013, 15 (8), pp.2275-2282. ⟨10.1039/c3gc40899j⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1039/c3gc40899j hal-01227411 https://hal.science/hal-01227411 doi:10.1039/c3gc40899j PRODINRA: 332459 WOS: 000322121400033 |
op_doi |
https://doi.org/10.1039/c3gc40899j |
container_title |
Green Chemistry |
container_volume |
15 |
container_issue |
8 |
container_start_page |
2275 |
_version_ |
1802646608114876416 |