Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects
Background: The arthritis of rheumatic fever is very responsive to treatment with salicylates, but there are many adverse reactions, especially hepatotoxicity, due to aspirin (acetylsalicylic acid) therapy. These sideeffects change the course and duration of rheumatic fever. Other non-steroidal anti...
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Pediatrics International
2003
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ftinonuuniv:oai:abakus.inonu.edu.tr:11616/7710 2023-05-15T18:12:51+02:00 Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects Karademir, Selmin Oğuz, Deniz Şenocak, Filiz Öcal, Burhan Karakurt, Cemşit Çabuk, Feryal İnönü Üniversitesi 113274 2003 application/pdf http://hdl.handle.net/11616/7710 eng eng Pediatrics International Pediatrics International Karademir, S. Oğuz, D. Şenocak, F. Öcal, B. Karakurt, C. Çabuk, F. (2003). Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects. Pediatrics International. 45, 676–679. http://hdl.handle.net/11616/7710 45 676 679 info:eu-repo/semantics/openAccess Aspirin Rheumatic fever Tolmetin article 2003 ftinonuuniv 2022-03-28T19:48:02Z Background: The arthritis of rheumatic fever is very responsive to treatment with salicylates, but there are many adverse reactions, especially hepatotoxicity, due to aspirin (acetylsalicylic acid) therapy. These sideeffects change the course and duration of rheumatic fever. Other non-steroidal anti-inflammatory drugs may be equally effective, although no reports are available. Methods: We studied 72 patients with rheumatic fever who were admitted to Dr Sami Ulus Children’s Hospital between 1995 and 1999. Twenty patients with arthritis were treated with tolmetin (25 mg/kg per day; group I) and 52 patients with arthritis and/or mild carditis were put on aspirin therapy (75–100 mg/kg per day) for 4–6 weeks (group II). Arthritis had disappeared at the same time in both the aspirin and tolmetin groups (P = 0.675). Results: The erythrocyte sedimentation rates of patients upon admission, at the first week and at the end of therapy were not different in the two groups (P > 0.05). No adverse effect of tolmetin therapy was observed, whereas side-effects of salicylate were observed in 19 patients (36.5%) in the aspirin group. Hepatotoxicity, gastric irritation and salicylism were found in 16, four and three patients, respectively. Renal toxicity and Reye syndrome were not demonstrated. Because of these side-effects of aspirin, therapy had to be stopped for 10–20 days and the duration of hospitalization in this group was lengthened unnecessarily. Conclusion: Tolmetin was safe and effective treatment for arthritic rheumatic fever patients without carditis. Tolmetin can be used particularly in patients who cannot tolerate aspirin. Article in Journal/Newspaper sami Unknown |
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English |
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Aspirin Rheumatic fever Tolmetin |
spellingShingle |
Aspirin Rheumatic fever Tolmetin Karademir, Selmin Oğuz, Deniz Şenocak, Filiz Öcal, Burhan Karakurt, Cemşit Çabuk, Feryal Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects |
topic_facet |
Aspirin Rheumatic fever Tolmetin |
description |
Background: The arthritis of rheumatic fever is very responsive to treatment with salicylates, but there are many adverse reactions, especially hepatotoxicity, due to aspirin (acetylsalicylic acid) therapy. These sideeffects change the course and duration of rheumatic fever. Other non-steroidal anti-inflammatory drugs may be equally effective, although no reports are available. Methods: We studied 72 patients with rheumatic fever who were admitted to Dr Sami Ulus Children’s Hospital between 1995 and 1999. Twenty patients with arthritis were treated with tolmetin (25 mg/kg per day; group I) and 52 patients with arthritis and/or mild carditis were put on aspirin therapy (75–100 mg/kg per day) for 4–6 weeks (group II). Arthritis had disappeared at the same time in both the aspirin and tolmetin groups (P = 0.675). Results: The erythrocyte sedimentation rates of patients upon admission, at the first week and at the end of therapy were not different in the two groups (P > 0.05). No adverse effect of tolmetin therapy was observed, whereas side-effects of salicylate were observed in 19 patients (36.5%) in the aspirin group. Hepatotoxicity, gastric irritation and salicylism were found in 16, four and three patients, respectively. Renal toxicity and Reye syndrome were not demonstrated. Because of these side-effects of aspirin, therapy had to be stopped for 10–20 days and the duration of hospitalization in this group was lengthened unnecessarily. Conclusion: Tolmetin was safe and effective treatment for arthritic rheumatic fever patients without carditis. Tolmetin can be used particularly in patients who cannot tolerate aspirin. |
author2 |
İnönü Üniversitesi 113274 |
format |
Article in Journal/Newspaper |
author |
Karademir, Selmin Oğuz, Deniz Şenocak, Filiz Öcal, Burhan Karakurt, Cemşit Çabuk, Feryal |
author_facet |
Karademir, Selmin Oğuz, Deniz Şenocak, Filiz Öcal, Burhan Karakurt, Cemşit Çabuk, Feryal |
author_sort |
Karademir, Selmin |
title |
Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects |
title_short |
Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects |
title_full |
Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects |
title_fullStr |
Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects |
title_full_unstemmed |
Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects |
title_sort |
tolmetin and salicylate therapy in acute rheumatic fever comparison of clinical efficacy and side effects |
publisher |
Pediatrics International |
publishDate |
2003 |
url |
http://hdl.handle.net/11616/7710 |
genre |
sami |
genre_facet |
sami |
op_relation |
Pediatrics International Karademir, S. Oğuz, D. Şenocak, F. Öcal, B. Karakurt, C. Çabuk, F. (2003). Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects. Pediatrics International. 45, 676–679. http://hdl.handle.net/11616/7710 45 676 679 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1766185335679614976 |