Hemolytic uremic syndrome outbreak in Turkey in 2011

• Main Authors: Ekinci, Z, Candan, C, Alpay, H, Canpolat, N, Akyuz, SG, Gunduz, Z, Dursun, I, Bek, K, Dursun, H, Isiyel, E, Oktem, F, Tabel, Y, Akil, I, Delibas, A, Gulleroglu, K, Akinci, N, Dincel, N, Ozkaya, O, Soylemezoglu, O
• Language: unknown
• Published: 2013
• Subjects: Ege; sami
• Online Access: http://hdl.handle.net/11616/27905

The aim of this retrospective multicenter study was to define the epidemiological and clinical features and prognostic factors of the first diarrhea-related hemolytic uremic syndrome (D+HUS) outbreak in Turkey in 2011. All pediatric nephrology centers in Turkey were asked about D+HUS patients via e-mail. Seventy D+HUS patients (median age: 5.7 years) participated. The seasonal peak was around the 7th, 8th and 9th months with 44 cases, centered in the east Marmara region. No causative agent could be identified. The rate of neurological complications and mortality was 21.4% and 4.2%, respectively. Eculizumab was used in four cases. Two of them had severe neurological complications despite plasma exchange. Elevated polymorphonuclear leukocyte count during hospital admission was the predictor of both severe disease and poor outcome. Duration of prodrome was the predictor of poor outcome (p<0.05). In conclusion, the median age of the affected children was greater than in the previous reports, while clinical features and outcome were similar. C1 [Ekinci, Zelal; Bek, Kenan] Kocaeli Univ, Fac Med, Dept Pediat, Div Pediat Nephrol, Kocaeli, Turkey. [Isiyel, Emel; Soylemezoglu, Oguz] Gazi Univ, Fac Med, Div Pediat Nephrol, Dept Pediat, Ankara, Turkey. [Candan, Cengiz] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey. [Alpay, Harika] Marmara Univ, Fac Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey. [Akyuz, Sare Gulfem] Dr Sami Ulus Training & Res Hosp, Div Pediat Nephrol, Dept Pediat, Ankara, Turkey. [Gunduz, Zubeyde; Dursun, Ismail] Erciyes Univ, Fac Med, Div Pediat Nephrol, Dept Pediat, Kayseri, Turkey. [Canpolat, Nur] Istanbul Univ, Cerrahpasa Fac Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey. [Dursun, Hasan] Bakirkoy Dr Sadi Training & Res Hosp, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey. [Oktem, Faruk] Bezmialem Fac Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey. [Tabel, Yilmaz] Inonu Univ, Turgut Ozal Med Ctr, Div Pediat Nephrol, Dept Pediat, Malatya, Turkey. [Akil, Ipek] Celal Bayar Univ, Fac Med, Div Pediat Nephrol, Dept Pediat, Manisa, Turkey. [Isiyel, Emel; Delibas, Ali] Mersin Univ, Fac Med, Div Pediat Nephrol, Dept Pediat, Mersin, Turkey. [Gulleroglu, Kaan] Baskent Univ, Fac Med, Div Pediat Nephrol, Dept Pediat, TR-06490 Ankara, Turkey. [Akinci, Nurver] Sisli Etfal Training & Res Hosp, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey. [Dincel, Nida] Ege Univ, Fac Med, Div Pediat Nephrol, Dept Pediat, Izmir, Turkey. [Ozkaya, Ozan] Ondokuz Mayis Univ, Fac Med, Div Pediat Nephrol, Dept Pediat, Samsun, Turkey.