Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar)
Not Available Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and...
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ftindiancar:oai:krishi.icar.gov.in:123456789/72739 2023-05-15T15:30:57+02:00 Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar) Not Available Dhamotharan K, Tengs T, Wessel Ø, Braaen S, Nyman IB, Hansen EF, Christiansen DH, Dahle MK, Rimstad E, Markussen T 2019-05-21 http://krishi.icar.gov.in/jspui/handle/123456789/72739 English eng Not Available Not Available; Not Available http://krishi.icar.gov.in/jspui/handle/123456789/72739 HSMI PRV-1 Piscine orthoreovirus reassortment viral evolution virulence Research Paper 2019 ftindiancar 2022-10-31T06:42:00Z Not Available Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and sequence analyses of 31 PRV-1 genomes collected over a 30-year period from fish with or without HSMI, grouped the viral sequences into two main monophylogenetic clusters, one associated with HSMI and the other with low virulent PRV-1 isolates. A PRV-1 strain from Norway sampled in 1988, a decade before the emergence of HSMI, grouped with the low virulent HSMI cluster. The two distinct monophylogenetic clusters were particularly evident for segments S1 and M2. Only a limited number of amino acids were unique to the association with HSMI, and they all located to S1 and M2 encoded proteins. The observed co-evolution of the S1-M2 pair coincided in time with the emergence of HSMI in Norway, and may have evolved through accumulation of mutations and/or segment reassortment. Sequences of S1-M2 suggest selection of the HSMI associated pair, and that this segment pair has remained almost unchanged in Norwegian salmon aquaculture since 1997. PRV-1 strains from the North American Pacific Coast and Faroe Islands have not undergone this evolution, and are more closely related to the PRV-1 precursor strains not associated with clinical HSMI. Not Available Report Atlantic salmon Faroe Islands Salmo salar KRISHI Publication and Data Inventory Repository (Knowledge based Resources Information Systems Hub for Innovations in Agriculture - Indian Council of Agricultural Research, ICAR) Faroe Islands Pacific Norway |
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Open Polar |
collection |
KRISHI Publication and Data Inventory Repository (Knowledge based Resources Information Systems Hub for Innovations in Agriculture - Indian Council of Agricultural Research, ICAR) |
op_collection_id |
ftindiancar |
language |
English |
topic |
HSMI PRV-1 Piscine orthoreovirus reassortment viral evolution virulence |
spellingShingle |
HSMI PRV-1 Piscine orthoreovirus reassortment viral evolution virulence Dhamotharan K, Tengs T, Wessel Ø, Braaen S, Nyman IB, Hansen EF, Christiansen DH, Dahle MK, Rimstad E, Markussen T Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar) |
topic_facet |
HSMI PRV-1 Piscine orthoreovirus reassortment viral evolution virulence |
description |
Not Available Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and sequence analyses of 31 PRV-1 genomes collected over a 30-year period from fish with or without HSMI, grouped the viral sequences into two main monophylogenetic clusters, one associated with HSMI and the other with low virulent PRV-1 isolates. A PRV-1 strain from Norway sampled in 1988, a decade before the emergence of HSMI, grouped with the low virulent HSMI cluster. The two distinct monophylogenetic clusters were particularly evident for segments S1 and M2. Only a limited number of amino acids were unique to the association with HSMI, and they all located to S1 and M2 encoded proteins. The observed co-evolution of the S1-M2 pair coincided in time with the emergence of HSMI in Norway, and may have evolved through accumulation of mutations and/or segment reassortment. Sequences of S1-M2 suggest selection of the HSMI associated pair, and that this segment pair has remained almost unchanged in Norwegian salmon aquaculture since 1997. PRV-1 strains from the North American Pacific Coast and Faroe Islands have not undergone this evolution, and are more closely related to the PRV-1 precursor strains not associated with clinical HSMI. Not Available |
format |
Report |
author |
Dhamotharan K, Tengs T, Wessel Ø, Braaen S, Nyman IB, Hansen EF, Christiansen DH, Dahle MK, Rimstad E, Markussen T |
author_facet |
Dhamotharan K, Tengs T, Wessel Ø, Braaen S, Nyman IB, Hansen EF, Christiansen DH, Dahle MK, Rimstad E, Markussen T |
author_sort |
Dhamotharan K, Tengs T, Wessel Ø, Braaen S, Nyman IB, Hansen EF, Christiansen DH, Dahle MK, Rimstad E, Markussen T |
title |
Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar) |
title_short |
Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar) |
title_full |
Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar) |
title_fullStr |
Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar) |
title_full_unstemmed |
Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar) |
title_sort |
evolution of the piscine orthoreovirus genome linked to emergence of heart and skeletal muscle inflammation in farmed atlantic salmon (salmo salar) |
publisher |
Not Available |
publishDate |
2019 |
url |
http://krishi.icar.gov.in/jspui/handle/123456789/72739 |
geographic |
Faroe Islands Pacific Norway |
geographic_facet |
Faroe Islands Pacific Norway |
genre |
Atlantic salmon Faroe Islands Salmo salar |
genre_facet |
Atlantic salmon Faroe Islands Salmo salar |
op_relation |
Not Available; Not Available http://krishi.icar.gov.in/jspui/handle/123456789/72739 |
_version_ |
1766361434731577344 |