Moving to an HbA1c based diagnosis of diabetes has a different impact on prevalence in different ethnic groups
Objective: To compare screen detected diabetes prevalence and the degree of diagnostic agreement by ethnicity with the current OGTT-based and newly proposed HbA 1c -based diagnostic criteria. Research design and methods: Six studies (1999-2009) from Denmark, United Kingdom, Australia, Greenland, Ken...
Main Authors: | , , , , , , , , |
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Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
American Diabetes Association
2009
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Subjects: | |
Online Access: | http://repository.ias.ac.in/84427/ http://care.diabetesjournals.org/content/early/2009/12/14/dc09-1843 |
Summary: | Objective: To compare screen detected diabetes prevalence and the degree of diagnostic agreement by ethnicity with the current OGTT-based and newly proposed HbA 1c -based diagnostic criteria. Research design and methods: Six studies (1999-2009) from Denmark, United Kingdom, Australia, Greenland, Kenya, and India were tested for the probability of an HbA 1c ≥ 6.5% among diabetes cases based on an OGTT. The difference in probability between centers was analyzed by logistic regression adjusting for relevant confounders. Results: Diabetes prevalence was lower with the HbA 1c -based diagnostic criteria in four out of six studies. The probability of an HbA 1c ≥ 6.5% among OGTT-diagnosed cases ranged widely (17.0 to 78.0%) by study center. Differences in diagnostic agreement between ethnic sub-groups in the United Kingdom study were of the same magnitude as between-country comparisons. Conclusions: A shift to an HbA 1c -based diagnosis for diabetes will have substantially different consequences for diabetes prevalence across ethnic groups and populations. |
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