Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate

n-Butyl levulinate is used as an important intermediate having diverse applications. The present work focuses on the synthesis of n-butyl levulinate by esterification of levulinic acid with n-butanol by using immobilized lipases. Novozym 435 (Candida antarctica lipase) was found to be the most effic...

Full description

Bibliographic Details
Main Authors: Yadav, Ganapati D., Borkar, Indrakant V.
Format: Article in Journal/Newspaper
Language:unknown
Published: American Chemical Society 2008
Subjects:
T Technology (General)
Antarc*
Antarctica
Online Access:http://repository.ias.ac.in/111656/
http://pubs.acs.org/doi/abs/10.1021/ie800193f
_version_ 1821618982091751424
author Yadav, Ganapati D.
Borkar, Indrakant V.
author_facet Yadav, Ganapati D.
Borkar, Indrakant V.
author_sort Yadav, Ganapati D.
collection Indian Academy of Sciences: Publication of Fellows
description n-Butyl levulinate is used as an important intermediate having diverse applications. The present work focuses on the synthesis of n-butyl levulinate by esterification of levulinic acid with n-butanol by using immobilized lipases. Novozym 435 (Candida antarctica lipase) was found to be the most efficient catalyst, and tetra-butyl methyl ether was the best solvent. Effects of various parameters were studied to analyze the kinetics and mechanism of the lipase action. Ping-pong bi−bi mechanism with n-butanol substrate inhibition was found to describe the kinetics of the reaction. The kinetic parameters evaluated from initial rate data were used to simulate the experimental results. There was a very good agreement between theory and experiment.
format Article in Journal/Newspaper
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
id ftindianacasci:oai:repository.ias.ac.in:111656
institution Open Polar
language unknown
op_collection_id ftindianacasci
op_relation Yadav, Ganapati D.
Borkar, Indrakant V. (2008) Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate Industrial & Engineering Chemistry Research, 47 (10). pp. 3358-3363. ISSN 0888-5885
publishDate 2008
publisher American Chemical Society
record_format openpolar
spelling ftindianacasci:oai:repository.ias.ac.in:111656 2025-01-16T19:10:04+00:00 Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate Yadav, Ganapati D. Borkar, Indrakant V. 2008 http://repository.ias.ac.in/111656/ http://pubs.acs.org/doi/abs/10.1021/ie800193f unknown American Chemical Society Yadav, Ganapati D. Borkar, Indrakant V. (2008) Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate Industrial & Engineering Chemistry Research, 47 (10). pp. 3358-3363. ISSN 0888-5885 T Technology (General) Article PeerReviewed 2008 ftindianacasci 2017-09-15T22:09:53Z n-Butyl levulinate is used as an important intermediate having diverse applications. The present work focuses on the synthesis of n-butyl levulinate by esterification of levulinic acid with n-butanol by using immobilized lipases. Novozym 435 (Candida antarctica lipase) was found to be the most efficient catalyst, and tetra-butyl methyl ether was the best solvent. Effects of various parameters were studied to analyze the kinetics and mechanism of the lipase action. Ping-pong bi−bi mechanism with n-butanol substrate inhibition was found to describe the kinetics of the reaction. The kinetic parameters evaluated from initial rate data were used to simulate the experimental results. There was a very good agreement between theory and experiment. Article in Journal/Newspaper Antarc* Antarctica Indian Academy of Sciences: Publication of Fellows
spellingShingle T Technology (General)
Yadav, Ganapati D.
Borkar, Indrakant V.
Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate
title Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate
title_full Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate
title_fullStr Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate
title_full_unstemmed Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate
title_short Kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate
title_sort kinetic modeling of immobilized lipase catalysis in synthesis of n-butyl levulinate
topic T Technology (General)
topic_facet T Technology (General)
url http://repository.ias.ac.in/111656/
http://pubs.acs.org/doi/abs/10.1021/ie800193f

Similar Items